ID A0A388SA05_9BURK Unreviewed; 134 AA.
AC A0A388SA05; A0A401LKM9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 08-OCT-2025, entry version 26.
DE RecName: Full=Putative iron-sulfur cluster insertion protein ErpA {ECO:0000256|HAMAP-Rule:MF_01380};
GN Name=erpA {ECO:0000256|HAMAP-Rule:MF_01380,
GN ECO:0000313|EMBL:GBO93108.1};
GN ORFNames=MESMUL_04620 {ECO:0000313|EMBL:GBO93108.1};
OS Mesosutterella multiformis.
OC Bacteria; Pseudomonadati; Pseudomonadota; Betaproteobacteria;
OC Burkholderiales; Sutterellaceae; Mesosutterella.
OX NCBI_TaxID=2259133 {ECO:0000313|EMBL:GBO93108.1, ECO:0000313|Proteomes:UP000266091};
RN [1] {ECO:0000313|EMBL:GBO93108.1, ECO:0000313|Proteomes:UP000266091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=4NBBH2 {ECO:0000313|EMBL:GBO93108.1,
RC ECO:0000313|Proteomes:UP000266091};
RX PubMed=30394865; DOI=10.1099/ijsem.0.003096;
RA Sakamoto M., Ikeyama N., Kunihiro T., Iino T., Yuki M., Ohkuma M.;
RT "Mesosutterella multiformis gen. nov., sp. nov., a member of the family
RT Sutterellaceae and Sutterella megalosphaeroides sp. nov., isolated from
RT human faeces.";
RL Int. J. Syst. Evol. Microbiol. 68:3942-3950(2018).
CC -!- FUNCTION: Required for insertion of 4Fe-4S clusters.
CC {ECO:0000256|HAMAP-Rule:MF_01380}.
CC -!- COFACTOR:
CC Name=iron-sulfur cluster; Xref=ChEBI:CHEBI:30408;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01380};
CC Note=Binds 1 iron-sulfur cluster per subunit. {ECO:0000256|HAMAP-
CC Rule:MF_01380};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01380}.
CC -!- SIMILARITY: Belongs to the HesB/IscA family. {ECO:0000256|HAMAP-
CC Rule:MF_01380}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GBO93108.1}.
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DR EMBL; BGZJ01000001; GBO93108.1; -; Genomic_DNA.
DR RefSeq; WP_022444331.1; NZ_BGZJ01000001.1.
DR AlphaFoldDB; A0A388SA05; -.
DR OrthoDB; 9801228at2; -.
DR Proteomes; UP000266091; Unassembled WGS sequence.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:TreeGrafter.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:TreeGrafter.
DR GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR FunFam; 2.60.300.12:FF:000002; Iron-sulfur cluster insertion protein ErpA; 1.
DR Gene3D; 2.60.300.12; HesB-like domain; 1.
DR HAMAP; MF_01380; Fe_S_insert_ErpA; 1.
DR InterPro; IPR016092; ATAP.
DR InterPro; IPR000361; ATAP_core_dom.
DR InterPro; IPR023063; ErpA_proteobact.
DR InterPro; IPR017870; FeS_cluster_insertion_CS.
DR InterPro; IPR035903; HesB-like_dom_sf.
DR NCBIfam; TIGR00049; iron-sulfur cluster assembly accessory protein; 1.
DR NCBIfam; NF010147; PRK13623.1; 1.
DR PANTHER; PTHR43011; IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43011:SF1; IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL; 1.
DR Pfam; PF01521; Fe-S_biosyn; 1.
DR SUPFAM; SSF89360; HesB-like domain; 1.
DR PROSITE; PS01152; HESB; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|HAMAP-Rule:MF_01380};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|HAMAP-
KW Rule:MF_01380};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW Rule:MF_01380}; Reference proteome {ECO:0000313|Proteomes:UP000266091}.
FT DOMAIN 25..129
FT /note="Core"
FT /evidence="ECO:0000259|Pfam:PF01521"
FT BINDING 62
FT /ligand="iron-sulfur cluster"
FT /ligand_id="ChEBI:CHEBI:30408"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01380"
FT BINDING 126
FT /ligand="iron-sulfur cluster"
FT /ligand_id="ChEBI:CHEBI:30408"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01380"
FT BINDING 128
FT /ligand="iron-sulfur cluster"
FT /ligand_id="ChEBI:CHEBI:30408"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01380"
SQ SEQUENCE 134 AA; 14550 MW; 04C887CFB32E8AF3 CRC64;
MAEEKAVAQN TEGEVPDFAA MPDPIQFSDA AVDAVKGLLD EEKKKNPDVN LMLRIFVQGG
GCSGFQYGFE FVEKAEDDDT RIVKGDVTFL VDSMSYQYLV GASVDFKDDL DGKQFVIKNP
NATTTCGCGS SFNV
//
