ID A0A395N220_9HYPO Unreviewed; 930 AA.
AC A0A395N220;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 18-JUN-2025, entry version 27.
DE SubName: Full=Pre-mrna-splicing factor prp1 {ECO:0000313|EMBL:RFN54168.1};
GN ORFNames=FIE12Z_1550 {ECO:0000313|EMBL:RFN54168.1};
OS Fusarium flagelliforme.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium incarnatum-equiseti species complex.
OX NCBI_TaxID=2675880 {ECO:0000313|EMBL:RFN54168.1, ECO:0000313|Proteomes:UP000265631};
RN [1] {ECO:0000313|EMBL:RFN54168.1, ECO:0000313|Proteomes:UP000265631}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 13405 {ECO:0000313|EMBL:RFN54168.1,
RC ECO:0000313|Proteomes:UP000265631};
RX PubMed=29649280; DOI=10.1371/journal.ppat.1006946;
RA Proctor R.H., McCormick S.P., Kim H.S., Cardoza R.E., Stanley A.M.,
RA Lindo L., Kelly A., Brown D.W., Lee T., Vaughan M.M., Alexander N.J.,
RA Busman M., Gutierrez S.;
RT "Evolution of structural diversity of trichothecenes, a family of toxins
RT produced by plant pathogenic and entomopathogenic fungi.";
RL PLoS Pathog. 14:e1006946-e1006946(2018).
CC -!- SUBUNIT: Associated with the spliceosome.
CC {ECO:0000256|ARBA:ARBA00011524}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RFN54168.1}.
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DR EMBL; PXXK01000029; RFN54168.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A395N220; -.
DR STRING; 2594813.A0A395N220; -.
DR OrthoDB; 440128at2759; -.
DR Proteomes; UP000265631; Unassembled WGS sequence.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IEA:TreeGrafter.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IEA:TreeGrafter.
DR GO; GO:0000244; P:spliceosomal tri-snRNP complex assembly; IEA:TreeGrafter.
DR FunFam; 1.25.40.10:FF:001164; mRNA splicing factor (Prp1/Zer1), putative (AFU_orthologue AFUA_2G06070); 1.
DR FunFam; 1.25.40.10:FF:000256; Probable pre-mRNA splicing factor prp1; 1.
DR FunFam; 1.25.40.10:FF:000304; Putative Pre-mRNA-splicing factor prp1; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR010491; PRP1_N.
DR InterPro; IPR045075; Syf1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_rpt.
DR PANTHER; PTHR11246; PRE-MRNA SPLICING FACTOR; 1.
DR PANTHER; PTHR11246:SF1; PRE-MRNA-PROCESSING FACTOR 6; 1.
DR Pfam; PF06424; PRP1_N; 1.
DR Pfam; PF13428; TPR_14; 3.
DR Pfam; PF13432; TPR_16; 1.
DR Pfam; PF14559; TPR_19; 1.
DR SMART; SM00386; HAT; 10.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48452; TPR-like; 4.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265631};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 12..169
FT /note="PRP1 splicing factor N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06424"
FT REGION 1..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 112..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 930 AA; 104422 MW; C39785BB5A6EB7AE CRC64;
MSGRRDFLNQ AAPENYVAGL GRGATGFTTR SDLGPARDGP SEDQIKEALA KRAAQLGLAP
DKKGKEKEEE EGGGGDEERY QDPDNEVGLF AGGVYDKDDE EADKIWEWVD ERMDRRKRQR
EAREQAEKDE YERNNPKIQQ QFSDLKRALA TVTDDEWANL PEVGDLTGKN RRSKQALRDK
FYAVPDSVLA AARDSSQMGT TVVDDEMGSS NAGGEAADGT MTNFAKIGAA RDKVLKSRLE
QAGSDSTAPG TSTSIDPQGY LTSLGKKDTA SMDGNVGDVK RVRELLQSVV KTNPSNALGW
IAAARLEELA GKTVTARKTI DKGCAQCPKS EDAWLENIRL NHGSPNAKII ARRAIEANNN
SVRLWVEAMN LETLPSNKKR VIRQALDHIP ESEALWKEAV NLEESSDDAK LLLAKATELI
PLSIDLWLAL ARLETPENAQ KVLNRARKAC PTSHEIWIAA ARLQEQLGQG TKVNVIKRGV
QVLAKESAMP KREEWITEAE RCEEEGAVIT CQNIIRETLG WGLDEDDDRK DIWMEDARAS
INRGKYETAR AIYAYALRIF VNSRTMWQAA ADLERNHGNR ESLWQVLEKA VESCPKSEEL
WMMLAKEKWR AGELDGARLV LKRAFNQNPN NEDIWLSAVK LESENGNEEQ ARKLLEIARE
KAPTDRVWMK SVVFERVLGN VEAALDLILQ ALQLFPASPK LWMLKGQIYE DLGKIGPARE
AYGTGVKAVP KSVPLWLLYA RLEEQAGLTV KARSVLDRAR LAVPKNAELW CESVRLERRA
GNMTQAKSMM ARAHQEVPKS GLLWAEQIWY LEARTQRKAR VLEAMKTVDS NPVLFVVAAR
IFWSDRKLPQ AQKWFEKAIL RDSDYGDAWA WYYRFLCQHG TDEKRADVIT KCVLNEPRHG
EVWQAIAKKP ANARKSCEEV LKLVAEELEQ
//
