ID   A0A395S1W6_9HYPO        Unreviewed;      1124 AA.
AC   A0A395S1W6;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   28-JAN-2026, entry version 23.
DE   SubName: Full=Sphingosine kinase {ECO:0000313|EMBL:RGP66237.1};
GN   ORFNames=FLONG3_8909 {ECO:0000313|EMBL:RGP66237.1};
OS   Fusarium longipes.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX   NCBI_TaxID=694270 {ECO:0000313|EMBL:RGP66237.1, ECO:0000313|Proteomes:UP000266234};
RN   [1] {ECO:0000313|EMBL:RGP66237.1, ECO:0000313|Proteomes:UP000266234}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 20695 {ECO:0000313|EMBL:RGP66237.1,
RC   ECO:0000313|Proteomes:UP000266234};
RX   PubMed=29649280; DOI=10.1371/journal.ppat.1006946;
RA   Proctor R.H., McCormick S.P., Kim H.S., Cardoza R.E., Stanley A.M.,
RA   Lindo L., Kelly A., Brown D.W., Lee T., Vaughan M.M., Alexander N.J.,
RA   Busman M., Gutierrez S.;
RT   "Evolution of structural diversity of trichothecenes, a family of toxins
RT   produced by plant pathogenic and entomopathogenic fungi.";
RL   PLoS Pathog. 14:e1006946-e1006946(2018).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RGP66237.1}.
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DR   EMBL; PXOG01000222; RGP66237.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A395S1W6; -.
DR   STRING; 694270.A0A395S1W6; -.
DR   OrthoDB; 3853857at2759; -.
DR   Proteomes; UP000266234; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR   GO; GO:0016020; C:membrane; IEA:TreeGrafter.
DR   GO; GO:0001727; F:lipid kinase activity; IEA:UniProtKB-ARBA.
DR   GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:UniProtKB-ARBA.
DR   GO; GO:0046512; P:sphingosine biosynthetic process; IEA:TreeGrafter.
DR   Gene3D; 2.60.200.40; -; 1.
DR   Gene3D; 3.30.710.10; Potassium Channel Kv1.1, Chain A; 1.
DR   Gene3D; 3.40.50.10330; Probable inorganic polyphosphate/atp-NAD kinase, domain 1; 1.
DR   InterPro; IPR017438; ATP-NAD_kinase_N.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR   InterPro; IPR055916; DUF7493.
DR   InterPro; IPR050187; Lipid_Phosphate_FormReg.
DR   InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR12358:SF31; ACYLGLYCEROL KINASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR   Pfam; PF00781; DAGK_cat; 1.
DR   Pfam; PF24321; DUF7493; 1.
DR   SMART; SM00046; DAGKc; 1.
DR   SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR   SUPFAM; SSF54695; POZ domain; 1.
DR   PROSITE; PS50097; BTB; 1.
DR   PROSITE; PS50146; DAGK; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:RGP66237.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000266234};
KW   Transferase {ECO:0000313|EMBL:RGP66237.1}.
FT   DOMAIN          119..258
FT                   /note="DAGKc"
FT                   /evidence="ECO:0000259|PROSITE:PS50146"
FT   DOMAIN          900..969
FT                   /note="BTB"
FT                   /evidence="ECO:0000259|PROSITE:PS50097"
FT   REGION          580..627
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          851..876
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        596..612
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1124 AA;  125389 MW;  37B0F894B1CFF37D CRC64;
     MEEGVGMLLL LEGKKKLTIG VDGLELNDPI ARKAGRSSCA PLTSTGASND TIPFYNVLWA
     ESADNRITID YAIHASKKLI KPGKWEFELA AEDEDEAGGT TPAETFVKIL LSRAYGDAPP
     RKRAYVLVNP NSGPGKAVKQ WENEVKPLLD AAKMQLDVVI LKRGGEAVEL AQNADLSRYD
     TIMACSGDGT PHEIFNGLAK RPDAARALST MAVSHIPCGS GNAFSCNLYG SHRPSFAALA
     IIKGIVTPLD LVSVTSGNSR IISFLSQTLG LIAECDLGTE NMRWMGSARF EVGVVQRMYK
     KKCYPFDLAV KVEIEEKEGV KAHYKHHTST ASLAHLARSA ESTFVADGAG LPELKYGTIQ
     DELPEGWELI PYDKIGTFYA GNMAYMSPDA PFFAASLISD GLMDLVTIDG DLPFLTAIRV
     LLDVEAERLF DNPHVTYKKI SAYRIIPRDQ DDGYISIDGE KCPFGPFQAE IHQGLGRVIS
     KSGKYEASGP KGWDKVMPLR GRGGRMPPGA WGRLKPVEQD PLQDMGLPSK GDDRLLNHKT
     QEWYYNQIIS RFLAFCTEAG DKDSIIRSFE ALDIRTANPT PAAQYTKPPP GHVPSMTPST
     LAKDTTRTSE VTGSPPDDTV APSSSSLTSP LKALRSIIPS SGPTTAMLAA IEDSDNTKSL
     QDVLMALRKL REGLVATKRA DLFSIQAYIF SIRLSILVKH PESYHPAILH LLRYMAVWTP
     MVQSEIEEIA GYFMLDAACR RRDLTEAYFI RQDFNIRNKK LDRILKALAH DNYISWQAAK
     QQVDRYYLKL MEWADDDMRL HALKCFGRSY LHVDLPYLEF SAGRKWNELK EKDNVGWELE
     DEKVTIKRVR ARRSNRAMPQ PARKRARTKA AAKDDAAAAA EEQQSTIFTD RRTSWLVKGE
     MVELKVKTET FHVARSVLTK NSEYFEGCLA GHFVEAKKGV VEFDDDEIEP RYLGLYIGLA
     YSHSSIVPHT PPRPAQNPQT MAAKTPMRDY VEVYKLCDRF LSPEMGEFIM RCIDVAIGNG
     HRALYRTDGD EGTQKLLMRD FADGYEVLNM QQNAQVEMGE RMITYFCEGV SYRAWIDTME
     ELMDRPKFVA AVSRGFATKL RELQIRLKSI KRRELVGPGP VYVD
//