ID A0A3A9KBB6_9BACI Unreviewed; 418 AA.
AC A0A3A9KBB6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 18-JUN-2025, entry version 22.
DE RecName: Full=L-rhamnose isomerase {ECO:0000256|HAMAP-Rule:MF_00541, ECO:0000256|NCBIfam:TIGR01748};
DE EC=5.3.1.14 {ECO:0000256|HAMAP-Rule:MF_00541, ECO:0000256|NCBIfam:TIGR01748};
GN Name=rhaA {ECO:0000256|HAMAP-Rule:MF_00541,
GN ECO:0000313|EMBL:RKL66863.1};
GN ORFNames=CR203_13615 {ECO:0000313|EMBL:RKL66863.1};
OS Salipaludibacillus neizhouensis.
OC Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Bacillaceae.
OX NCBI_TaxID=885475 {ECO:0000313|EMBL:RKL66863.1, ECO:0000313|Proteomes:UP000281498};
RN [1] {ECO:0000313|EMBL:RKL66863.1, ECO:0000313|Proteomes:UP000281498}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KCTC 13187 {ECO:0000313|EMBL:RKL66863.1,
RC ECO:0000313|Proteomes:UP000281498};
RA Wang H.;
RT "Bacillus sp. nov., a halophilic bacterium isolated from a Keqin Lake.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the interconversion of L-rhamnose and L-rhamnulose.
CC {ECO:0000256|HAMAP-Rule:MF_00541}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-rhamnopyranose = L-rhamnulose; Xref=Rhea:RHEA:23160,
CC ChEBI:CHEBI:17897, ChEBI:CHEBI:62346; EC=5.3.1.14;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00541};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00541};
CC Note=Binds 1 Mn(2+) ion per subunit. {ECO:0000256|HAMAP-Rule:MF_00541};
CC -!- PATHWAY: Carbohydrate degradation; L-rhamnose degradation; glycerone
CC phosphate from L-rhamnose: step 1/3. {ECO:0000256|HAMAP-Rule:MF_00541}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00541}.
CC -!- SIMILARITY: Belongs to the rhamnose isomerase family.
CC {ECO:0000256|HAMAP-Rule:MF_00541}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RKL66863.1}.
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DR EMBL; PDOE01000005; RKL66863.1; -; Genomic_DNA.
DR RefSeq; WP_110934718.1; NZ_KZ614146.1.
DR AlphaFoldDB; A0A3A9KBB6; -.
DR OrthoDB; 9766697at2; -.
DR UniPathway; UPA00541; UER00601.
DR Proteomes; UP000281498; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008740; F:L-rhamnose isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019324; P:L-lyxose metabolic process; IEA:TreeGrafter.
DR GO; GO:0019301; P:rhamnose catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.20.20.150; Divalent-metal-dependent TIM barrel enzymes; 1.
DR HAMAP; MF_00541; RhaA; 1.
DR InterPro; IPR050337; L-rhamnose_isomerase.
DR InterPro; IPR009308; Rhamnose_isomerase.
DR InterPro; IPR036237; Xyl_isomerase-like_sf.
DR NCBIfam; NF002203; PRK01076.1; 1.
DR NCBIfam; TIGR01748; rhaA; 1.
DR PANTHER; PTHR30268; L-RHAMNOSE ISOMERASE; 1.
DR PANTHER; PTHR30268:SF0; L-RHAMNOSE ISOMERASE; 1.
DR Pfam; PF06134; RhaA; 1.
DR SUPFAM; SSF51658; Xylose isomerase-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00541};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|HAMAP-Rule:MF_00541};
KW Manganese {ECO:0000256|ARBA:ARBA00023211, ECO:0000256|HAMAP-Rule:MF_00541};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW Rule:MF_00541}; Reference proteome {ECO:0000313|Proteomes:UP000281498};
KW Rhamnose metabolism {ECO:0000256|ARBA:ARBA00023308, ECO:0000256|HAMAP-
KW Rule:MF_00541}.
FT BINDING 261
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00541"
FT BINDING 293
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00541"
FT BINDING 295
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00541"
SQ SEQUENCE 418 AA; 48089 MW; ADFCD27E0202DA34 CRC64;
MTVKENFELA KKAYEKWDID IDHVFAQLKQ VPISIHCWQG DDIGGFEVNQ SELSGGIEVT
GDYPGKATTP EELRQDIEKA LSLIPGKHRI NLHAIYAETD GIAVERDELE PKHFEKWVQW
AKKNGLGLDF NPTLFSHEKA SSGLTLSHPD KEIRQFWIDH CIASRKIGEY FGKELGTPCL
TNIWIPDGYK DTPSDRLTPR RRLKESLDEI YTVKLDEKFN IDAVESKVFG IGSESYVVGS
HEFYYGYALK NDKLCLLDTG HYHPTEMVSN KISSMLLYSE KLALHVSRPV RWDSDHVVTL
DDELKELALE IVRNDALNRV IIGLDFFDAS INRVAAWTIG TRNMIKALML GMLMPNEHLK
QLQEDGNFTE RLALLEEFKT YPFGAIWDYY CETMGVPERE NWLNDVKQYE KEVLSHRE
//
