ID A0A3B1IVY5_ASTMX Unreviewed; 125 AA.
AC A0A3B1IVY5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 18-JUN-2025, entry version 27.
DE RecName: Full=Transmembrane protein 14C {ECO:0000256|ARBA:ARBA00039421};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Acestrorhamphidae; Acestrorhamphinae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000033249.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000033249.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- FUNCTION: Required for normal heme biosynthesis.
CC {ECO:0000256|ARBA:ARBA00037428}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMEM14 family.
CC {ECO:0000256|ARBA:ARBA00007590}.
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DR RefSeq; XP_015464042.1; XM_015608556.1.
DR RefSeq; XP_049319658.1; XM_049463701.1.
DR AlphaFoldDB; A0A3B1IVY5; -.
DR FunCoup; A0A3B1IVY5; 698.
DR STRING; 7994.ENSAMXP00000033249; -.
DR Ensembl; ENSAMXT00000048159.1; ENSAMXP00000033249.1; ENSAMXG00000034552.1.
DR GeneID; 103026272; -.
DR GeneTree; ENSGT00940000154772; -.
DR InParanoid; A0A3B1IVY5; -.
DR OrthoDB; 5620at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000034552; Expressed in camera-type eye and 13 other cell types or tissues.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:TreeGrafter.
DR GO; GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0070453; P:regulation of heme biosynthetic process; IEA:TreeGrafter.
DR FunFam; 1.10.10.1740:FF:000002; Transmembrane protein 14C; 1.
DR Gene3D; 1.10.10.1740; Transmembrane protein 14-like; 1.
DR InterPro; IPR005349; TMEM14.
DR InterPro; IPR044890; TMEM14_sf.
DR PANTHER; PTHR12668; TRANSMEMBRANE PROTEIN 14, 15; 1.
DR PANTHER; PTHR12668:SF4; TRANSMEMBRANE PROTEIN 14C-RELATED; 1.
DR Pfam; PF03647; Tmemb_14; 1.
PE 3: Inferred from homology;
KW Heme biosynthesis {ECO:0000256|ARBA:ARBA00023133};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 48..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 125 AA; 12954 MW; 382373DD98450558 CRC64;
MNATAVTVFY NLVQQALIMT VDWAGYGYAA LVASGGVMGY VKAGSVPSLA AGLLFGGLAG
FGAYQISQDP KNIWVSLATS GTLAAIMGKR FYNSRKIMPA GIVAGASILM LTKIGIGFLQ
KPQES
//
