ID A0A3B1J527_ASTMX Unreviewed; 175 AA.
AC A0A3B1J527;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 18-JUN-2025, entry version 26.
DE SubName: Full=FCH and double SH3 domains 2 {ECO:0000313|Ensembl:ENSAMXP00000036945.1};
GN Name=FCHSD2 {ECO:0000313|Ensembl:ENSAMXP00000036945.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Acestrorhamphidae; Acestrorhamphinae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000036945.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000036945.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
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DR AlphaFoldDB; A0A3B1J527; -.
DR Ensembl; ENSAMXT00000038457.1; ENSAMXP00000036945.1; ENSAMXG00000013591.2.
DR GeneTree; ENSGT00510000046732; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000013591; Expressed in brain and 14 other cell types or tissues.
DR GO; GO:0031594; C:neuromuscular junction; IEA:TreeGrafter.
DR GO; GO:0055037; C:recycling endosome; IEA:TreeGrafter.
DR GO; GO:0007274; P:neuromuscular synaptic transmission; IEA:TreeGrafter.
DR GO; GO:0030833; P:regulation of actin filament polymerization; IEA:TreeGrafter.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR PANTHER; PTHR15735:SF11; F-BAR AND DOUBLE SH3 DOMAINS PROTEIN 2; 1.
DR PANTHER; PTHR15735; FCH AND DOUBLE SH3 DOMAINS PROTEIN; 1.
DR Pfam; PF00611; FCH; 1.
DR SMART; SM00055; FCH; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR PROSITE; PS51741; F_BAR; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 8..175
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT COILED 39..66
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 175 AA; 20790 MW; D79E6A6FCB5A481B CRC64;
MQPPPRKVKV TQELKTTHTE QLTRLHLKHQ TECDLLEDMR TYSQKKAALE RDYAQALQKL
ANQYLKRDWP GIKPDDQRTD YRNVYGVWRA YLEGTVQVTQ SRLFVSENYK NEISDPAKTV
RLYKEQQLKK VRPLLHTVCI ELQVSYMISG NEKWTINVEK QGSYNIKLDQ WISIY
//
