ID A0A3B1JIV9_ASTMX Unreviewed; 327 AA.
AC A0A3B1JIV9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 18-JUN-2025, entry version 34.
DE RecName: Full=Hyperpolarization activated cyclic nucleotide-gated potassium channel 4 {ECO:0008006|Google:ProtNLM};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Acestrorhamphidae; Acestrorhamphinae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000042342.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000042342.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3B1JIV9; -.
DR STRING; 7994.ENSAMXP00000042342; -.
DR Ensembl; ENSAMXT00000051072.1; ENSAMXP00000042342.1; ENSAMXG00000031836.1.
DR GeneTree; ENSGT00940000154743; -.
DR InParanoid; A0A3B1JIV9; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR GO; GO:0030424; C:axon; IEA:TreeGrafter.
DR GO; GO:0030425; C:dendrite; IEA:TreeGrafter.
DR GO; GO:0098855; C:HCN channel complex; IEA:TreeGrafter.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:TreeGrafter.
DR GO; GO:0003254; P:regulation of membrane depolarization; IEA:TreeGrafter.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IEA:TreeGrafter.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013621; Ion_trans_N.
DR InterPro; IPR051413; K/Na_HCN_channel.
DR PANTHER; PTHR45689; I[[H]] CHANNEL, ISOFORM E; 1.
DR PANTHER; PTHR45689:SF4; POTASSIUM_SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 4; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08412; Ion_trans_N; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00022826};
KW Ion transport {ECO:0000256|ARBA:ARBA00022826};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022826};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022826};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022826}.
FT TRANSMEM 181..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 259..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 137..179
FT /note="Ion transport N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08412"
FT DOMAIN 181..321
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..65
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..94
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 327 AA; 36890 MW; 591DD8A08020139E CRC64;
MKALPSAGAA EPRSADPAVA ETDVGRAAKA SSNGDCRRFR DSLSSLAGRH VHEPEPPAEE
KRLIAETDAS SPSEECSPPG PCGGTPRGAG GFGAAAGAAG AEQQQQPAFV KLDGIEHILA
DDERFYQEGG FMHRQFGAML QPGVNKFSLR MFGSEKAVER EQERVKSAGF WIIHPYSDFR
FYWDLTMLLL MVGNLIIIPV GITFFKDEHT PPWIVFNVVS DTFFLMDLVL NFRTGIVKED
NTEIILDPQQ IKIKYLRSWF VVDFISSIPV DYIFLIVETR IDSDFYKTAR ALRIVRFTKI
LSLLRLLRLS RLIRYIHQWE ECEFFFC
//
