ID A0A3B1K769_ASTMX Unreviewed; 735 AA.
AC A0A3B1K769;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 18-JUN-2025, entry version 32.
DE RecName: Full=Transcription factor RFX3 {ECO:0000256|ARBA:ARBA00040859};
DE AltName: Full=Regulatory factor X 3 {ECO:0000256|ARBA:ARBA00042137};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Acestrorhamphidae; Acestrorhamphinae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000050328.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000050328.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3B1K769; -.
DR Ensembl; ENSAMXT00000035768.1; ENSAMXP00000050328.1; ENSAMXG00000019201.2.
DR GeneTree; ENSGT01050000244879; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000019201; Expressed in olfactory epithelium and 4 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR FunFam; 1.10.10.10:FF:000017; transcription factor RFX3 isoform X1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003150; DNA-bd_RFX.
DR InterPro; IPR039779; RFX-like.
DR InterPro; IPR007668; RFX1_trans_act.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12619; RFX TRANSCRIPTION FACTOR FAMILY; 1.
DR PANTHER; PTHR12619:SF20; TRANSCRIPTION FACTOR RFX3; 1.
DR Pfam; PF25340; BCD_RFX; 1.
DR Pfam; PF04589; RFX1_trans_act; 1.
DR Pfam; PF02257; RFX_DNA_binding; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51526; RFX_DBD; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 156..231
FT /note="RFX-type winged-helix"
FT /evidence="ECO:0000259|PROSITE:PS51526"
SQ SEQUENCE 735 AA; 81526 MW; 827005C7F07F5D91 CRC64;
MQTPEAGADS TSTVPLQTSV PVQPAVTAQQ VASQVPVQQQ AQTVQQVQHV YPAQVQYVEE
NSGVYTNGTI RTYSYTEPQM YSQNSSGNYF DTQGSLSQVT TVVTSHSMAN NGNGLPMGLS
GGQIISSSGA YLIGGNTMDN SAPHSAAQTT RASPATLQWL LDNYETADGV SLPRSTLYSH
YLRHCQEQKL DPVNAASFGK LIRSIFMGLR TRRLGTRGNS KYHYYGIRVK PDSPLNRLQE
DMQYMALRQQ PVQQKQRYKP VQKMDGFSGD NYPSSGQHTP NAAEQTVIAQ SQHHQQFLDA
SRALPEFVEL DLGEHGVEDV SMEDIKALQT LYREHCEAIL DVVVNLQFSL IEKLWQTFWR
YSPSNTIEGA TIIQNSGVSE IEGRLPRARL LLLCRSEAVL KWMSACDHLM YQALVEILIP
DVLRPIPSAL TQAIRNFAKS LEGWLTNAMS AIPQKMIQTK VSTVSAFAQT LRRYTSLNHL
AQAARAVLQN TSQINQMLSD LNRVDFVNVQ EQASWVCQCE EGVVQRLEQD FKATLQQQSS
LEQWAAWLDN VVCQVLKPYE DRHTFPKAAR QFLLKWSFYS SMVIRDLTLR SAASFGSFHL
IRLLYDEYMF YLVEHRVAQA TGATAIGVMG EFGNLNAMLP TNIDKDEVSE MDSDLDEEME
EVDEPLAKRE KAEAEVIQVL QVGTMEDGSS AVVGVVQPGP IQLTAAGHTD HILGPVTGPT
TIRHCGGAGN AYASV
//
