ID A0A3B1KBY8_ASTMX Unreviewed; 1198 AA.
AC A0A3B1KBY8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 18-JUN-2025, entry version 32.
DE SubName: Full=CASK interacting protein 1 {ECO:0000313|Ensembl:ENSAMXP00000051585.1};
GN Name=CASKIN1 {ECO:0000313|Ensembl:ENSAMXP00000051585.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Acestrorhamphidae; Acestrorhamphinae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000051585.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000051585.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
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DR AlphaFoldDB; A0A3B1KBY8; -.
DR Ensembl; ENSAMXT00000054474.1; ENSAMXP00000051585.1; ENSAMXG00000006712.2.
DR GeneTree; ENSGT00940000158025; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000006712; Expressed in brain and 14 other cell types or tissues.
DR CDD; cd09498; SAM_caskin1_2_repeat2; 1.
DR FunFam; 1.10.150.50:FF:000032; caskin-1 isoform X1; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR InterPro; IPR033635; ANKS1/Caskin.
DR InterPro; IPR032232; Caskin1-CID.
DR InterPro; IPR035498; Caskin1/2_SAM_2.
DR InterPro; IPR032117; Caskin_C.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR PANTHER; PTHR24174; ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR24174:SF11; CASKIN-1; 1.
DR Pfam; PF16907; Caskin-Pro-rich; 1.
DR Pfam; PF16632; Caskin-tail; 1.
DR Pfam; PF16600; Caskin1-CID; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 295..359
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 109..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 775..1133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..145
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..186
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..466
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..495
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..513
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..675
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..797
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 869..878
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 931..945
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1016..1034
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1042..1056
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1073..1082
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1083..1098
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1099..1109
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1110..1121
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1198 AA; 128125 MW; 7CA16B33FC80D075 CRC64;
MCFFLLQVLE QHSDGRWKGC IHDNRTGNDR VGYFPSSIVE VICKRPGPTG SWSTVVSTQQ
YQTIPLCVSG CVSPGAAVLN GESYHEIHIL PPPPTPHAHQ PLFTSFGYSR SQSTSAEPLS
QQGARGSESS PHGSPTPSGG PQGCSNEEIW VLRKPVAGGD RSSVGSSGSV ASARSSGSGQ
SAGSSSHILH AQAEGVKLLA TVLSQSAKAK EHLLEQSKSL EHSSITTAKG PTSRSQSVSS
CPLHEQPYSE APQRKAEVLS EGKDLTAIGV TKPGHRKKMT SEINKLSVTE WTPDQKPANL
GEWLTMIGLS QYHQVLVQNG YENIEFITDI TWEDLQEIGI TKLGHQKKLM LAVKKLAELQ
KSSENRNMTR KKPQLSQDMV AIESPPPDSG ECMSPKMTTF QDSELSGELQ AALTRPGNTP
DGPDVRNNAN GGPVPQQRSR SLHENSINKS RDSEEPIGPP RKEARTMRQS SQAGSQRGST
SQPKPRQSYP QGSGPPYTPP QTPTKTKPPS SQTMGSSQAK PKPSPQLLQQ TERPMSPRPA
PQSPTHRAQP QPSPQPTESV EAVQPAPPVS VPLLCLPPEG DSDEGNEQGT PKKRAHSLNR
YAVSDGEQER EELNVQDTGG KYATVQHRVG RSNSMKGQAD KNVNRSQSFA LRQKKKGPPP
PPPKRSSSAI SSSSSNLTEV PKETGTTGHL LDVNYQPQRR ASDLGGTVDT GSAGSVRSIA
AMLEMSSIGG GAKGLAQKST GHFLQVGTAG GKQHDAIGLD GEVVNRRRTI SGPVTDLVAA
AKREQQSQPV QVQQVQDKPP KEPQPNSTGT SAENLPFAED GNLTIKQRPR QGKGEGEEVV
DSMYPLPQEE IPNVDGTGTL KRRAWSSKQH QEEAKFHLTE SNTVKRRPKS RETKESEEPQ
QEEPLVPPYQ NGTGTIKRRP TSEVTVSEQP RPQEHVENKP RRDSTDSTDS AARKPVKPPV
SPKPVLAQHL KKQIPPATVT KKASFPGPGA PGSPGTTQCG PFSCPVFTQL FEGKKIPPPI
SPKPTPPPTA PKPPKNVLQS MNPPPGQTPI PSPGKPPVVK IDSPVLATNP AKSPTPPTPP
AQSPQTPHTP QTPVTPQTPQ TPVPPPVKPP RSSISGVSMD SGSGGVGPGS GVISADAVHQ
KIEETSASLA AALLAVEEKI KEDRHRDSVS ENKSTVSILD DIGSMFDDLA DQLDAMLE
//
