ID A0A3B1KLF2_ASTMX Unreviewed; 975 AA.
AC A0A3B1KLF2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 18-JUN-2025, entry version 30.
DE SubName: Full=Huntingtin interacting protein 1 related {ECO:0000313|Ensembl:ENSAMXP00000054704.1};
GN Name=HIP1R {ECO:0000313|Ensembl:ENSAMXP00000054704.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Acestrorhamphidae; Acestrorhamphinae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000054704.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000054704.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the SLA2 family.
CC {ECO:0000256|ARBA:ARBA00010135}.
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DR AlphaFoldDB; A0A3B1KLF2; -.
DR Ensembl; ENSAMXT00000051186.1; ENSAMXP00000054704.1; ENSAMXG00000019400.2.
DR GeneTree; ENSGT00940000153594; -.
DR OrthoDB; 8178130at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000019400; Expressed in pharyngeal gill and 9 other cell types or tissues.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:TreeGrafter.
DR GO; GO:0030864; C:cortical actin cytoskeleton; IEA:TreeGrafter.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:TreeGrafter.
DR GO; GO:0035615; F:clathrin adaptor activity; IEA:TreeGrafter.
DR GO; GO:0032051; F:clathrin light chain binding; IEA:TreeGrafter.
DR GO; GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IEA:TreeGrafter.
DR GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:TreeGrafter.
DR GO; GO:0007015; P:actin filament organization; IEA:TreeGrafter.
DR GO; GO:0048268; P:clathrin coat assembly; IEA:TreeGrafter.
DR GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR FunFam; 1.20.5.1700:FF:000002; Huntingtin interacting protein 1; 1.
DR Gene3D; 1.20.5.1700; -; 1.
DR Gene3D; 6.10.250.920; -; 1.
DR Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR InterPro; IPR011417; ANTH_dom.
DR InterPro; IPR013809; ENTH.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR032422; HIP1_clath-bd.
DR InterPro; IPR035964; I/LWEQ_dom_sf.
DR InterPro; IPR002558; ILWEQ_dom.
DR InterPro; IPR030224; Sla2_fam.
DR PANTHER; PTHR10407; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR10407:SF10; HUNTINGTIN-INTERACTING PROTEIN 1-RELATED PROTEIN; 1.
DR Pfam; PF07651; ANTH; 1.
DR Pfam; PF16515; HIP1_clath_bdg; 1.
DR Pfam; PF01608; I_LWEQ; 1.
DR SMART; SM00273; ENTH; 1.
DR SMART; SM00307; ILWEQ; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF109885; I/LWEQ domain; 1.
DR PROSITE; PS50945; I_LWEQ; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..975
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017444321"
FT TRANSMEM 143..161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 669..915
FT /note="I/LWEQ"
FT /evidence="ECO:0000259|PROSITE:PS50945"
FT REGION 936..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 306..340
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 409..440
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 466..507
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 939..948
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 965..975
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 975 AA; 109465 MW; 616A73927E94BCF6 CRC64;
MNPFKITIFI VCFFLTPQLQ SIGKSITTTE AAIKEKYARK ILLGTHKEGG AVTFWSHAVS
LPLASNAILS WKFCHMVHKI LRDGHPNVSL IDQGSLHDRY GHIVALYSKF LCIKIEFHCK
VCRPLCTLII NGNYVTNKKK QSCLFALAYI LTSCIIFFAV FRQMESNSTS STTSVGQCRL
SPLVLVIQDC SPLCHFLVKL LFKLHSRVPV DALLGHRERF RDQFESLTKF FEKARSMEFF
KTIIQIPDLP DSPPNFLRAA SLAEYVKPVV VPNQQLPEDD DTETQLDFTE GPGYQMVRQF
VIFKVCVCAQ RVVIQLKEQV NKLEAEVEEQ RTHKQMALVE NEHLRMEVDA LRTQTAVAAS
IQATAEDAGR AQTAQIHFSR LKEKHAELVT RHADLMRKNT DTVKQLTSTQ HVQEELVRAK
QQMAEELEKL KQENSMMVDL PYTYMQGIQF ACLCLLQSGD QLSSLLVGLQ TEKEMLLRSM
KEQEAELANL RQATQLHQAT LQQEREKSQW ETSSLQNQLQ EKSSRESVLQ QKLQEEQFCL
LQCAVVEAEG IILDAMAKVD DPVHVRCIST PEYLINRAET TLVSMDKMQQ SHAGYLRNMD
DASGLLRAVT QFSHLAADTI VNGAATAHSV PTDQADRLTD NCRDCATHCL QFLKELKLKP
TLLRFVYMSS ICVRELIFSH SLQDLRRKDA DIQKAELADM VDMEMAATSS AIEDAVLRMD
EILSQARRDT SGLKLEAIHM LVTAATDLQK DIVESGRGVG SIKDFYAKNS CWTEGLISAS
KTVGWTATQM VESADKVVTD QGKYEELIVC SHEIAASTAQ LVAASKVNIH SNKKLHTLQQ
ASRHVNDMAA VVVSSTKAGQ MQIEDKSPMD FSSMSVIKLK TEEMESQVRV LELESKLSRE
REHLGELRKK HYELAGSPLD LPAQRNYDSF GLPSVLPELP LPDPPYPEPS LQFSIGSPRP
TFSTTPPPGP PVTPG
//
