ID A0A3B3BR30_ORYME Unreviewed; 273 AA.
AC A0A3B3BR30;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 18-JUN-2025, entry version 35.
DE SubName: Full=Homeobox protein SIX3 {ECO:0000313|EMBL:KAF6719394.1};
DE SubName: Full=SIX homeobox 3b {ECO:0000313|Ensembl:ENSOMEP00000007935.1};
GN ORFNames=FQA47_017404 {ECO:0000313|EMBL:KAF6719394.1};
OS Oryzias melastigma (Marine medaka).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=30732 {ECO:0000313|Ensembl:ENSOMEP00000007935.1, ECO:0000313|Proteomes:UP000261560};
RN [1] {ECO:0000313|Ensembl:ENSOMEP00000007935.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (DEC-2024) to UniProtKB.
RN [2] {ECO:0000313|EMBL:KAF6719394.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bigg-433 {ECO:0000313|EMBL:KAF6719394.1};
RX PubMed=32938378;
RA Liang P., Saqib H.S.A., Ni X., Shen Y.;
RT "Long-read sequencing and de novo genome assembly of marine medaka (Oryzias
RT melastigma).";
RL BMC Genomics 21:0-0(0).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the SIX/Sine oculis homeobox family.
CC {ECO:0000256|ARBA:ARBA00008161}.
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DR EMBL; WKFB01000625; KAF6719394.1; -; Genomic_DNA.
DR STRING; 30732.ENSOMEP00000007935; -.
DR PaxDb; 30732-ENSOMEP00000007935; -.
DR Ensembl; ENSOMET00000003273.1; ENSOMEP00000007935.1; ENSOMEG00000009091.1.
DR GeneTree; ENSGT00940000160346; -.
DR OMA; HHHMCSD; -.
DR OrthoDB; 3501850at2759; -.
DR Proteomes; UP000261560; Unplaced.
DR Proteomes; UP000646548; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:TreeGrafter.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0048596; P:embryonic camera-type eye morphogenesis; IEA:Ensembl.
DR GO; GO:0021631; P:optic nerve morphogenesis; IEA:Ensembl.
DR GO; GO:0070654; P:sensory epithelium regeneration; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR FunFam; 1.10.10.60:FF:000046; SIX homeobox 3; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR001356; HD.
DR InterPro; IPR009057; Homeodomain-like_sf.
DR InterPro; IPR031701; SIX1_SD.
DR PANTHER; PTHR10390; HOMEOBOX PROTEIN SIX; 1.
DR PANTHER; PTHR10390:SF12; HOMEOBOX PROTEIN SIX6; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF16878; SIX1_SD; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000646548}.
FT DOMAIN 167..227
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 169..228
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 240..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 273 AA; 30889 MW; 5A29216F4A6645CB CRC64;
MVFRAPLDFF SASRLLLPHF ADGPPVLPGS RSPDHPPAGF PSLALPGLCF SATQIASVCE
TLEETGDIER LARFLWSLPV TTDGRDSISE HESVQRARAV VAFHTGCYRE LYRILETHRF
TRASHSKLQA MWLEAHYREA EKLRGRPLGP VDKYRVRKKF PLPRTIWDGE QKTHCFKERT
RGLLREWYLQ DPYPNPGKKR ELAHATGLTP TQVGNWFKNR RQRDRAAAAK NRLQHHRICP
DGACTLSGGD SSAERADGET FLSVTDSDSD LDV
//
