ID A0A3B3HD48_ORYLA Unreviewed; 1385 AA.
AC A0A3B3HD48;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 18-JUN-2025, entry version 34.
DE SubName: Full=Nuclear receptor coactivator 1 {ECO:0000313|Ensembl:ENSORLP00000029475.1};
GN Name=ncoa1 {ECO:0000313|Ensembl:ENSORLP00000029475.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000029475.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000029475.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000029475.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000029475.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000029475.1};
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SRC/p160 nuclear receptor coactivator
CC family. {ECO:0000256|ARBA:ARBA00009933}.
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DR RefSeq; XP_023808908.1; XM_023953140.1.
DR STRING; 8090.ENSORLP00000029475; -.
DR Ensembl; ENSORLT00000027015.1; ENSORLP00000029475.1; ENSORLG00000029837.1.
DR GeneID; 101163052; -.
DR GeneTree; ENSGT00950000183021; -.
DR InParanoid; A0A3B3HD48; -.
DR Proteomes; UP000001038; Chromosome 24.
DR Bgee; ENSORLG00000029837; Expressed in liver and 14 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016922; F:nuclear receptor binding; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0032870; P:cellular response to hormone stimulus; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd18948; bHLH-PAS_NCoA1_SRC1; 1.
DR CDD; cd00130; PAS; 1.
DR FunFam; 3.30.450.20:FF:000007; Nuclear receptor coactivator; 1.
DR Gene3D; 6.10.140.410; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR056193; bHLH_NCOA1-3.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR010011; NCO_DUF1518.
DR InterPro; IPR028819; NCOA1_bHLH.
DR InterPro; IPR009110; Nuc_rcpt_coact.
DR InterPro; IPR014920; Nuc_rcpt_coact_Ncoa-typ.
DR InterPro; IPR037077; Nuc_rcpt_coact_Ncoa_int_sf.
DR InterPro; IPR017426; Nuclear_rcpt_coactivator.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR014935; SRC/p160_LXXLL.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR10684; NUCLEAR RECEPTOR COACTIVATOR; 1.
DR PANTHER; PTHR10684:SF1; NUCLEAR RECEPTOR COACTIVATOR 1; 1.
DR Pfam; PF23172; bHLH_NCOA; 1.
DR Pfam; PF08815; Nuc_rec_co-act; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR Pfam; PF08832; SRC-1; 1.
DR SMART; SM01151; DUF1518; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF69125; Nuclear receptor coactivator interlocking domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 23..80
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 109..180
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 669..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 958..984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1122..1267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1357..1385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..449
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..525
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..700
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 749..758
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..771
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 960..979
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1138..1149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1175..1188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1229..1246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1357..1375
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1376..1385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1385 AA; 145829 MW; 99EC26F69F20306E CRC64;
MSAVGEPPLD PATPESRKRR GSPCDTSGQS LEKRRRQLEC RYIVELAELL SSHMSDILTL
SVKPDKCHIL KTTVDQIQQL RRREQEALLS PDDVQNSDIS SSSQGLAEKE ALGPVLLEAL
DGFFFVVNRE GRIIFVSENV TSYLGYSQEE LMTSSVYSIL HVGNHSEFVR NLLPDSLVNG
APWPQESSRR SSRSFSCRML KRPPDEMDSE NQEARQQYEI LQCFTVSQSG AAPQEGDDPQ
SCLICIACRA PRAQTVSTES FATKQDPTGK IVSIETSALR AKGRPGWEDL VRRCIYAFFQ
SQGKEPSHAK KLLHEVMTHG SAVSPPYHFS SGDGALLSAQ TRCKFCCPPN PEEQPFILGI
HSIYREHNTA SSQENTNLPL TPPSLLPGTN SSQGSGPATS GLYSNAPSLG HGPATPAGYL
TPSRTKCPQR VGSPSPLSSP HTATPTSFMS PRVLQASPGL GGSPQVPGNP FSPSTPGVAS
PAQSGGSGLS RQQSAGECTG GGASFPLSSP VLQRRASTPT CSSTWLPPAT PSEGGDNGAD
RPPLPSPSLQ RLQDGSGAGT DNITSSRHPQ NPPTPCPSSH SSLTERHKIL HRLLQDNSPG
DAPPPSEDGL CQNKVSIKRE PPTSPTLRSA SREPQDHQLL RFLLDTDEKD LGDLPPPSAL
NLQTVRVKVE KRASGEGLVC PGPGDASRLG LSSPRSSPVG ENRRDSTSSV EPADGPPQLK
PETRSSFGAK QISDDPLNPG GTPKGHSPAP QPPAPLLSPV PQLQSPSSQL PSPAPRLTSP
CQLTPGEAGA PRSVSVKKEP PSTPSRGMAD SGAPSGCRSQ SLDFCSPATP CQQPDPLQRG
KDGSQFPEVD DGEPFSSSSG LIKMDMGDLQ FQPLALADTL SFDTLGPPPQ ASLASPQEQC
VPCTLDEVLG PPTTPEGRSE ESSLLEQLVS FLSGTDESEL AELDKALGID KLVQGGCLEP
SLQTSPPQQP TATPVPTYPS QLATAPQPSF LSELVAAGPQ GLGFGALRGA FPAATASVGL
RVPRPQGVGP PLRLPPNQLR LQLQQRVQGP QQLQNRLAAM THFPAGAQNV TLGGRPGLQQ
PQIPSQPPLN AQMLAQRQRE LYSIQHRQRQ LIQQKVMLMR QNIGGPPTAT TGLPKAPPTT
SQQQFNITPG YNPMTGNPPT SPSPFSPVSG GGQDSKLSVR SPLKNQSLMG GGQSQFDGAA
ISSLQPGLFP PFGTSEAVQP DSPFPPEMSP TSPLLSPQNS TSQSPLHHQA PPTGYQSPDM
KSWPQGSLFT PPGQSGGSLF GQQGLYNNMS ITVSMAGGSG AVAPLPPMGQ AAGTGGLGGV
GSACGEQQVQ QLQVFADVQC TVNLVGGESY LNQGAVGAAQ KAAGAPAPQS GPAQQKSLLQ
QLLTE
//
