ID A0A3B3IKJ6_ORYLA Unreviewed; 1199 AA.
AC A0A3B3IKJ6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 10-JUN-2026, entry version 38.
DE SubName: Full=SKI2 subunit of superkiller complex {ECO:0000313|Ensembl:ENSORLP00000044359.1};
GN Name=skic2 {ECO:0000313|Ensembl:ENSORLP00000044359.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000044359.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000044359.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000044359.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000044359.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000044359.1};
RG Ensembl;
RL Submitted (JAN-2026) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00047984};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR AlphaFoldDB; A0A3B3IKJ6; -.
DR Ensembl; ENSORLT00000027253.1; ENSORLP00000044359.1; ENSORLG00000002021.2.
DR GeneTree; ENSGT00940000158255; -.
DR Proteomes; UP000001038; Chromosome 11.
DR Bgee; ENSORLG00000002021; Expressed in ovary and 15 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd18027; DEXHc_SKIV2L; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR FunFam; 3.40.50.300:FF:000354; ATP-dependent RNA helicase SKI2; 1.
DR FunFam; 3.40.50.300:FF:000447; helicase SKI2W isoform X2; 1.
DR FunFam; 1.10.3380.30:FF:000015; SKI2 homolog, superkiller viralicidic activity 2-like; 1.
DR Gene3D; 1.10.3380.30; -; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR025696; Beta-barrel_MTR4.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C-like.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR050699; RNA-DNA_Helicase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR InterPro; IPR040801; Ski2_N.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF1; ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR Pfam; PF17911; Ski2_N; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 327..483
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 598..763
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 137..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..237
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..290
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1199 AA; 134007 MW; 2D003FF28EAB20F7 CRC64;
MDRINVPPVG PADLPLSLLE LGCSGRFELI THPVPGQPLP PQSTLPHGLP PTSLNLETEV
EKQFLRDPAW LPIHDTDFVF QKFLKVAQRK VDVDSLLSCS PSALPSGLSV VRDPTTGMLL
DFTEVLLENT GLSAKNSLSL QRQPGPPSES LRGSNTNYPF LPGGMEELSL DEIRKKSELE
EEIDFEKDLL KVPPGFKVGM DFTSKEIKIA KPEVNLMSLL SEVEDSADLQ REEEEKDEEQ
KKEKASNVLR TNSLEDLGIK TQDVAPPSST SKGRKEDRSK PTESPEEKKK WAIPVDITSP
CDDFYKRIPN PAFKWPFELD VFQKQAILRL EAHDSVFVAA HTSAGKTVVA EYAIALSQKH
MTRTIYTSPI KALSNQKFRD FKTTFKDVGL LTGDVQLSPE SACLIMTTEI LRSMLYNGSE
VIRDLEWVIF DEVHYINDAE RGVVWEEVLI MLPDHVSIIL LSATVPNALE FSEWIGRIKK
KHIYVISTMK RPVPLEHHLY TGNSTKTQKE MFLLVDAAGN FLTKGYYAAV DAKKERSSKH
AQTFGAKNTS QNTTASQDRS VWLALLHFLS QRQQTPVVAF TFSRARCDDN ARSLESMDLT
TSVEKAEIHS FFQKSLSRLR GGDRQLPQIL LMRDLLKRGV AVHHSGILPI LKEVIEMLFS
RGLVKVLFAT ETFAMGVNMP ARTVVFDSIR KHDGTGFRNL LPGEYIQMAG RAGRRGLDAT
GTVIILCKAG VHEMADLHAM MMGKPTILQS QFRLTYTMIL NLLRVEALRV TDMMKRSFSE
SHRNAQEHEK RISQLRQTLS SLPPLDPEGQ LSDLLPYYHT VAELRVTNES LQKAIVESVN
GLKALSVGRV LVVNNKQHLN ALGVILQVSS DAVNRTFTAL IICEKGNEEG KGEPDAASPH
LYNTALFIPE GPCSHTVQKL KLQDISAITV KTLKVIPDRI IDNYNKRQQP RFRHEPPGQA
ISTATQELLR LAEANPGGLA TLDPVNDLQL KSVDVVEGSM RLRLLQDSLK SFTCIHSPTF
AEQFARVKER MSVQEELDRL LFLVSDQSLT LLPEYHQRIK VLQSLQYIDS GGAVQLKGRV
ACQISSHELL LTELLFENVM SPLAPEESAA LLSCLVFTQK TQVEPHLTST LKEPFAEIAL
LTDIQEGTVV RCIQRLDEVL KEVRQAARIV GDSVLGSKME RASLAIRRDI VFTASLYTH
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