ID A0A3B3IN73_ORYLA Unreviewed; 136 AA.
AC A0A3B3IN73;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 18-JUN-2025, entry version 30.
DE SubName: Full=Calcitonin/calcitonin-related polypeptide, alpha {ECO:0000313|Ensembl:ENSORLP00000045334.1};
GN Name=calca {ECO:0000313|Ensembl:ENSORLP00000045334.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000045334.1, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000045334.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000045334.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000045334.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000045334.1};
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the calcitonin family.
CC {ECO:0000256|ARBA:ARBA00009222}.
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DR RefSeq; XP_011487247.1; XM_011488945.1.
DR AlphaFoldDB; A0A3B3IN73; -.
DR STRING; 8090.ENSORLP00000045334; -.
DR Ensembl; ENSORLT00000044345.1; ENSORLP00000045334.1; ENSORLG00000029182.1.
DR GeneTree; ENSGT00940000156267; -.
DR InParanoid; A0A3B3IN73; -.
DR Proteomes; UP000001038; Chromosome 3.
DR Bgee; ENSORLG00000029182; Expressed in intestine and 4 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0031716; F:calcitonin receptor binding; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR InterPro; IPR021118; Calcitonin.
DR InterPro; IPR021117; Calcitonin-like.
DR InterPro; IPR021116; Calcitonin/adrenomedullin.
DR InterPro; IPR001693; Calcitonin_peptide-like.
DR PANTHER; PTHR10505:SF16; CALCITONIN; 1.
DR PANTHER; PTHR10505; CALCITONIN-RELATED; 1.
DR Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR PRINTS; PR00270; CALCITONINA.
DR SMART; SM00113; CALCITONIN; 1.
PE 3: Inferred from homology;
KW Amidation {ECO:0000256|ARBA:ARBA00022815};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR621116-50};
KW Hormone {ECO:0000256|ARBA:ARBA00022702};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..136
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017240505"
FT DOMAIN 80..117
FT /note="Calcitonin peptide-like"
FT /evidence="ECO:0000259|SMART:SM00113"
FT DISULFID 82..88
FT /evidence="ECO:0000256|PIRSR:PIRSR621116-50"
SQ SEQUENCE 136 AA; 15356 MW; AB3EE058F2E5A49D CRC64;
MTMLKLWTLL LANALLLCQM YISEAAPSRT SKEFVTDGVP LLNNEAETLF RAIKDYIEMT
SEEAAKEEAE EESLDRPLSK RCTGLSTCVL GRLSQDIHKL QTYPRTDVGA GTPGKKRSLF
EQFENYSKSN IGNYHF
//
