ID A0A3B5KGC6_TAKRU Unreviewed; 483 AA.
AC A0A3B5KGC6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 28-JAN-2026, entry version 28.
DE RecName: Full=Suppressor of fused homolog {ECO:0000256|ARBA:ARBA00071231, ECO:0000256|PIRNR:PIRNR011844};
GN Name=sufu {ECO:0000313|Ensembl:ENSTRUP00000054421.1};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000054421.1, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000054421.1, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000054421.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSTRUP00000054421.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR011844}.
CC Nucleus {ECO:0000256|PIRNR:PIRNR011844}.
CC -!- SIMILARITY: Belongs to the SUFU family. {ECO:0000256|ARBA:ARBA00060754,
CC ECO:0000256|PIRNR:PIRNR011844}.
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DR AlphaFoldDB; A0A3B5KGC6; -.
DR STRING; 31033.ENSTRUP00000054421; -.
DR Ensembl; ENSTRUT00000055500.2; ENSTRUP00000054421.1; ENSTRUG00000011691.3.
DR GeneTree; ENSGT00390000009747; -.
DR InParanoid; A0A3B5KGC6; -.
DR OMA; CQIVGVT; -.
DR Proteomes; UP000005226; Chromosome 4.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-ARBA.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-ARBA.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IEA:UniProtKB-ARBA.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:UniProtKB-ARBA.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-ARBA.
DR FunFam; 3.30.1360.230:FF:000001; Suppressor of fused homolog; 1.
DR Gene3D; 3.30.1360.230; Sufu, C-terminal domain; 1.
DR InterPro; IPR020941; SUFU-like_domain.
DR InterPro; IPR024314; SUFU_C.
DR InterPro; IPR038489; SUFU_C_sf.
DR InterPro; IPR037181; SUFU_N.
DR InterPro; IPR007768; Suppressor_of_fused.
DR InterPro; IPR016591; Suppressor_of_fused_euk.
DR PANTHER; PTHR10928; SUPPRESSOR OF FUSED; 1.
DR PANTHER; PTHR10928:SF2; SUPPRESSOR OF FUSED HOMOLOG; 1.
DR Pfam; PF05076; SUFU; 1.
DR Pfam; PF12470; SUFU_C; 1.
DR PIRSF; PIRSF011844; Suppressor_of_fused_protein; 1.
DR SUPFAM; SSF103359; Suppressor of Fused, N-terminal domain; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR011844};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR011844};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT TRANSMEM 447..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 53..229
FT /note="Suppressor of fused-like"
FT /evidence="ECO:0000259|Pfam:PF05076"
FT DOMAIN 243..444
FT /note="Suppressor of fused C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12470"
FT REGION 267..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..322
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..334
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 483 AA; 54462 MW; 12B55C1FA624A014 CRC64;
MDEVRPSSGA QAHGLSPLFP PGLQAIYAEC RRLYPEQANP LQVTAIVKYW LGGPDPLDYI
SMYRNVGCPS QDVQEHWHYV SFGLSDLYGD NRVHEFTGSD GPSGFGFELT FRLKREAGET
APPTWPAELM QGLARYVFQS ENTFCSGDHV SWHSPLDNSE SRIQHMLLTE DPQMQPIQTP
FGTVAFLQIV GVCTEELQAA QQWNGQGILE LMRGVRVAGG PWLITDMRRG ETIFDIDPHL
QQERVDQGIE TEGSNLSGVS AKCVWDDLSR PPEDEEDSRS ICIGSQPRRL SEKDTEQIRE
TLKKGLEFNT KATLPPISSQ RQIQERPQSR KDSLESESSA AIIPHELVRT RQLESVHLKF
NQESGTLLPL CLRGRLLHGR HFTYKSIHGD TAITFVSSGV EGAFATEEHP YAAHGPWLQI
LLTEEFVEQM LGDIQELGTR DEVRVKGFAL LLRFWAIAYM FQLFAFSLCR PNYQRSTVGQ
KRS
//
