ID A0A3B6A3U0_WHEAT Unreviewed; 922 AA.
AC A0A3B6A3U0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 28-JAN-2026, entry version 34.
DE RecName: Full=Argonaute 4 {ECO:0008006|Google:ProtNLM};
GN Name=LOC123183434 {ECO:0000313|EnsemblPlants:TraesCS1D02G453600.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS1D02G453600.1};
RN [1] {ECO:0000313|EnsemblPlants:TraesCS1D02G453600.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS1D02G453600.1};
RA Rossello M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblPlants:TraesCS1D02G453600.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
CC -!- FUNCTION: Probably involved in the RNA silencing pathway. May bind to
CC short RNAs such as microRNAs (miRNAs) or short interfering RNAs
CC (siRNAs), and represses the translation of mRNAs which are
CC complementary to them. {ECO:0000256|ARBA:ARBA00056927}.
CC -!- SIMILARITY: Belongs to the argonaute family. Ago subfamily.
CC {ECO:0000256|ARBA:ARBA00008201}.
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DR RefSeq; XP_044452180.1; XM_044596245.1.
DR RefSeq; XP_044452181.1; XM_044596246.1.
DR AlphaFoldDB; A0A3B6A3U0; -.
DR SMR; A0A3B6A3U0; -.
DR STRING; 4565.A0A3B6A3U0; -.
DR PaxDb; 4565-Traes_1DL_64B330BBB.2; -.
DR EnsemblPlants; TraesCS1D02G453600.1; TraesCS1D02G453600.1; TraesCS1D02G453600.
DR GeneID; 123183434; -.
DR Gramene; TraesARI1D03G00584370.1; TraesARI1D03G00584370.1; TraesARI1D03G00584370.
DR Gramene; TraesCLE_scaffold_006023_01G000300.1; TraesCLE_scaffold_006023_01G000300.1; TraesCLE_scaffold_006023_01G000300.
DR Gramene; TraesCS1D02G453600.1; TraesCS1D02G453600.1; TraesCS1D02G453600.
DR Gramene; TraesCS1D03G1045600.1; TraesCS1D03G1045600.1.CDS; TraesCS1D03G1045600.
DR Gramene; TraesJUL1D03G00580820.1; TraesJUL1D03G00580820.1; TraesJUL1D03G00580820.
DR Gramene; TraesJUL1D03G00580820.2; TraesJUL1D03G00580820.2; TraesJUL1D03G00580820.
DR Gramene; TraesLDM1D03G00580390.1; TraesLDM1D03G00580390.1; TraesLDM1D03G00580390.
DR Gramene; TraesLDM1D03G00580390.2; TraesLDM1D03G00580390.2; TraesLDM1D03G00580390.
DR Gramene; TraesMAC1D03G00577270.1; TraesMAC1D03G00577270.1; TraesMAC1D03G00577270.
DR Gramene; TraesMAC1D03G00577270.2; TraesMAC1D03G00577270.2; TraesMAC1D03G00577270.
DR Gramene; TraesNOR1D03G00585260.1; TraesNOR1D03G00585260.1; TraesNOR1D03G00585260.
DR Gramene; TraesNOR1D03G00585260.3; TraesNOR1D03G00585260.3; TraesNOR1D03G00585260.
DR Gramene; TraesROB_scaffold_019684_01G000200.1; TraesROB_scaffold_019684_01G000200.1; TraesROB_scaffold_019684_01G000200.
DR Gramene; TraesSTA1D03G00577260.1; TraesSTA1D03G00577260.1; TraesSTA1D03G00577260.
DR Gramene; TraesSTA1D03G00577260.2; TraesSTA1D03G00577260.2; TraesSTA1D03G00577260.
DR Gramene; TraesSYM1D03G00585430.1; TraesSYM1D03G00585430.1; TraesSYM1D03G00585430.
DR Gramene; TraesSYM1D03G00585430.2; TraesSYM1D03G00585430.2; TraesSYM1D03G00585430.
DR Gramene; TraesWEE_scaffold_003455_01G000400.1; TraesWEE_scaffold_003455_01G000400.1; TraesWEE_scaffold_003455_01G000400.
DR OMA; HPDRIDW; -.
DR OrthoDB; 10252740at2759; -.
DR Proteomes; UP000019116; Chromosome 1D.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0004521; F:RNA endonuclease activity; IBA:GO_Central.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IBA:GO_Central.
DR CDD; cd02846; PAZ_argonaute_like; 1.
DR CDD; cd04657; Piwi_ago-like; 1.
DR FunFam; 3.30.420.10:FF:000091; Protein argonaute 3; 1.
DR FunFam; 2.170.260.10:FF:000008; Protein argonaute 7; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 2.170.260.10; paz domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR014811; ArgoL1.
DR InterPro; IPR032472; ArgoL2.
DR InterPro; IPR032474; Argonaute_N.
DR InterPro; IPR003100; PAZ_dom.
DR InterPro; IPR036085; PAZ_dom_sf.
DR InterPro; IPR003165; Piwi.
DR InterPro; IPR045246; Piwi_ago-like.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR22891; EUKARYOTIC TRANSLATION INITIATION FACTOR 2C; 1.
DR Pfam; PF08699; ArgoL1; 1.
DR Pfam; PF16488; ArgoL2; 1.
DR Pfam; PF16486; ArgoN; 1.
DR Pfam; PF02170; PAZ; 1.
DR Pfam; PF02171; Piwi; 1.
DR SMART; SM01163; DUF1785; 1.
DR SMART; SM00950; Piwi; 1.
DR SUPFAM; SSF101690; PAZ domain; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50821; PAZ; 1.
DR PROSITE; PS50822; PIWI; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW RNA-mediated gene silencing {ECO:0000256|ARBA:ARBA00023158}.
FT DOMAIN 293..406
FT /note="PAZ"
FT /evidence="ECO:0000259|PROSITE:PS50821"
FT DOMAIN 575..882
FT /note="Piwi"
FT /evidence="ECO:0000259|PROSITE:PS50822"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 888..907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..23
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..37
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..48
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..177
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 922 AA; 102361 MW; 542F983C30BDD706 CRC64;
MDPHDGEPAA DELPPPPPLP PNVVPIIAED AAAASESEPP PPPPPSKPAK PRRHIMARPP
NGLGKKGQPI QLLANHYKVS VKPSEEFFNH YYVNLKYEDD TPVDSKGIGR KVLDKLQHTY
HSELADKDFA YDGEKSLFTI GALPQINNEF IVVLEDIGSG KTAAGSPGGN NGSPGGGDQK
RVRRPYQAKT FKVELNFAAT IPMAAIGHAI RGQESEHSLE ALRVLDIILR QHSAKQGCLL
VRQSFFHNNP SSFVDLGGGV MGCRGFHSSF RGTQSGLSLN IDVSTTMIVK PGPVIDFLLA
NQKVDHPDKI DWQKAKRALK NLRIKTTPAN SEFKIVGLSE RNCNEQMFPL RRRNGDTTET
VEITVYDYFV KNRGIELRYS GNLPCINAGR PKRPTYFPVE LCTLVPLQRY TKALSTMQRT
SLVEKSRQKP HERMSTLNDA LKRSNYDADP MLKACGIQIA QNFTQIEGRV LPAPKLKAGN
GEEFFARNGR WNIARKKLIR TSSVKRWSVV NFSARCDLRG LVQDLKRVAT GMGLEYEDPH
TVIEESPSLR RAPVARRVEE MFAQIKAKLP GAPLFLLCLL PERKNCEVYG PWKKKCLADF
GIVTQCLAPQ RVNDQYLSNL LLKINAKLGG LNTLLQIEAA RAIPIVGKVP TIILGMDVSH
GQPGQSDRPS IAAVVSSREW PLISKYRATV HTQSPKQEMM ASLFKPRGTE DDGLIRESLI
DFYTSSGKRK PDQVIIFRDG VSESQFTQVI NIELEQIIEA CKCLDDKWEP KFTVIVAQKN
HHTRFFQTNS PENVPPGTVV DKQVCHPKNF DFYMCAHAGM IGTSRPTHYH VLHDEIGFSG
DELQEFVHSL SYVYQRSTTA ISVAAPIAYA HLAAAQVGTF MKFDDMSDTS SSQGGGHTSV
GSAPVPELPR LHEKVRSSMF FC
//
