ID A0A3B6RNN0_WHEAT Unreviewed; 901 AA.
AC A0A3B6RNN0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 28-JAN-2026, entry version 33.
DE RecName: Full=Argonaute 4 {ECO:0008006|Google:ProtNLM};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS7A02G533100.1};
RN [1] {ECO:0000313|EnsemblPlants:TraesCS7A02G533100.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS7A02G533100.1};
RA Rossello M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblPlants:TraesCS7A02G533100.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
CC -!- FUNCTION: Probably involved in the RNA silencing pathway. May bind to
CC short RNAs such as microRNAs (miRNAs) or short interfering RNAs
CC (siRNAs), and represses the translation of mRNAs which are
CC complementary to them. {ECO:0000256|ARBA:ARBA00056927}.
CC -!- SIMILARITY: Belongs to the argonaute family. Ago subfamily.
CC {ECO:0000256|ARBA:ARBA00008201}.
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DR AlphaFoldDB; A0A3B6RNN0; -.
DR SMR; A0A3B6RNN0; -.
DR STRING; 4565.A0A3B6RNN0; -.
DR PaxDb; 4565-Traes_7AL_1BAB53DCE.1; -.
DR EnsemblPlants; TraesCS7A02G533100.1; TraesCS7A02G533100.1; TraesCS7A02G533100.
DR Gramene; TraesCS7A02G533100.1; TraesCS7A02G533100.1; TraesCS7A02G533100.
DR Gramene; TraesCS7A03G1295500.1; TraesCS7A03G1295500.1.CDS; TraesCS7A03G1295500.
DR Gramene; TraesKAR7A01G0457820.1; cds.TraesKAR7A01G0457820.1; TraesKAR7A01G0457820.
DR Gramene; TraesROB_scaffold_099093_01G000100.1; TraesROB_scaffold_099093_01G000100.1; TraesROB_scaffold_099093_01G000100.
DR Gramene; TraesWEE_scaffold_040704_01G000100.1; TraesWEE_scaffold_040704_01G000100.1; TraesWEE_scaffold_040704_01G000100.
DR OMA; THANSEF; -.
DR OrthoDB; 10252740at2759; -.
DR Proteomes; UP000019116; Chromosome 7A.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0004521; F:RNA endonuclease activity; IBA:GO_Central.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IBA:GO_Central.
DR CDD; cd02846; PAZ_argonaute_like; 1.
DR CDD; cd04657; Piwi_ago-like; 1.
DR FunFam; 3.30.420.10:FF:000091; Protein argonaute 3; 1.
DR FunFam; 2.170.260.10:FF:000008; Protein argonaute 7; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 2.170.260.10; paz domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR014811; ArgoL1.
DR InterPro; IPR032472; ArgoL2.
DR InterPro; IPR032473; Argonaute_Mid_dom.
DR InterPro; IPR032474; Argonaute_N.
DR InterPro; IPR003100; PAZ_dom.
DR InterPro; IPR036085; PAZ_dom_sf.
DR InterPro; IPR003165; Piwi.
DR InterPro; IPR045246; Piwi_ago-like.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR22891; EUKARYOTIC TRANSLATION INITIATION FACTOR 2C; 1.
DR Pfam; PF08699; ArgoL1; 1.
DR Pfam; PF16488; ArgoL2; 1.
DR Pfam; PF16487; ArgoMid; 1.
DR Pfam; PF16486; ArgoN; 1.
DR Pfam; PF02170; PAZ; 1.
DR Pfam; PF02171; Piwi; 1.
DR SMART; SM01163; DUF1785; 1.
DR SMART; SM00949; PAZ; 1.
DR SMART; SM00950; Piwi; 1.
DR SUPFAM; SSF101690; PAZ domain; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50821; PAZ; 1.
DR PROSITE; PS50822; PIWI; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW RNA-mediated gene silencing {ECO:0000256|ARBA:ARBA00023158}.
FT DOMAIN 279..393
FT /note="PAZ"
FT /evidence="ECO:0000259|PROSITE:PS50821"
FT DOMAIN 563..873
FT /note="Piwi"
FT /evidence="ECO:0000259|PROSITE:PS50822"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..21
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..36
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..47
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 901 AA; 101591 MW; 08078B8F7538257D CRC64;
MDLSDGGPEE LPPPPPLPPD VVPIRAEEDV AEELPRNKPA KPKRLPKARP GLGKRGQTIQ
LLANHYKVSM RSSEDFFHHY HVNLKYEDDQ PVVRKGIGRK VLDKLQHMYR SELANNEFAY
DGEKSLFTIG ALPQVHNEFT VVLEDIRSGK CSGGNSGSSP GGSDTKRVKR PYKTKIFKVE
LCFVAKIPTA AITQALRGQE SENSLEALRV LDIILRQHSA KQGCLLLHQS FFHNNPRNFV
DLKGGVVGCR GFHSSFRGTQ SGLSLNIDVS TTMLVKPGPV IDFLLANQMV DHPNRIDWSK
AKRALKNLRI KTTHANSEFK IFGLSEKKCN EQTFLLRRKD GDNGDINTVE ITVHEYFVHN
RGIELRYSYL PCINAGRRNR PTYFPVELCE LVPLQRYTKD LSTLQRSSLV EKSRQMPHER
MSILNNALKR TNYDSDPMVK ACGISIARHF TQIEGRVLPA PKLKAGNGEE FFPRNGRWNL
SKKKLIRTCS VNKWAVVNFS AECDVHGLVR DLKRIATEMG IKIEYPYCDV IEESPSARRA
PASRRVDEMF AKINSNPPGD PKFLLSLLPV RKNCEIYGPW KRKCLVECGI FTQCLAPPRK
VNDQYLINVL LKINAKLGGL NTLLQCELSP APAVLSIVGK LPTIILGMYV SHGQPGQSDR
PSTAAVVNSR EWPLISKYRA TVHTQSPKLE MMSSLFKPWG KDDGLIRESL IDFYTSSGNR
KPEQIIIFRD GVSESQFTQV INIELEQIIE ACKFLDETWE PKFTVIVAQK NHHTRFFQTE
SPNNVPPGTV VDKEVCHPKN FDFYMCAHAG MIGTSRPTHY HVLHDEIGFT ADELQEFVHS
LSYVYQRSTT AILVVAPIMY AHLAAAQVGT FVKFEDMSAG SIPVPELPRL HENVRSSMFF
C
//
