ID A0A3E2HPZ6_SCYLI Unreviewed; 2637 AA.
AC A0A3E2HPZ6;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 05-FEB-2025, entry version 28.
DE RecName: Full=F-box domain-containing protein {ECO:0000259|PROSITE:PS50181};
DE Flags: Fragment;
GN ORFNames=B7463_g904 {ECO:0000313|EMBL:RFU35438.1};
OS Scytalidium lignicola (Hyphomycete).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Scytalidium.
OX NCBI_TaxID=5539 {ECO:0000313|EMBL:RFU35438.1, ECO:0000313|Proteomes:UP000258309};
RN [1] {ECO:0000313|EMBL:RFU35438.1, ECO:0000313|Proteomes:UP000258309}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 105466 {ECO:0000313|EMBL:RFU35438.1,
RC ECO:0000313|Proteomes:UP000258309};
RA Buettner E., Gebauer A.M., Hofrichter M., Liers C., Kellner H.;
RT "Draft genome sequence of Scytalidium lignicola DSM 105466, a ubiquitous
RT saprotrophic fungus.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the APC1 family.
CC {ECO:0000256|ARBA:ARBA00010547}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RFU35438.1}.
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DR EMBL; NCSJ02000008; RFU35438.1; -; Genomic_DNA.
DR STRING; 5539.A0A3E2HPZ6; -.
DR OMA; YIGTMDS; -.
DR OrthoDB; 26401at2759; -.
DR Proteomes; UP000258309; Unassembled WGS sequence.
DR GO; GO:0005680; C:anaphase-promoting complex; IEA:InterPro.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:TreeGrafter.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IEA:TreeGrafter.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007091; P:metaphase/anaphase transition of mitotic cell cycle; IEA:TreeGrafter.
DR GO; GO:0070979; P:protein K11-linked ubiquitination; IEA:TreeGrafter.
DR CDD; cd09917; F-box_SF; 1.
DR FunFam; 1.10.1040.10:FF:000017; 2-dehydropantoate 2-reductase; 1.
DR FunFam; 1.25.10.10:FF:000400; 20S cyclosome subunit (APC1/BimE), putative; 1.
DR FunFam; 1.25.10.10:FF:000435; Ubiquitin ligase subunit; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 3.
DR Gene3D; 1.10.1040.10; N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR024990; Apc1.
DR InterPro; IPR048971; Apc1_3rd.
DR InterPro; IPR049255; Apc1_N.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR013332; KPR_N.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR12827:SF3; ANAPHASE-PROMOTING COMPLEX SUBUNIT 1; 1.
DR PANTHER; PTHR12827; MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER; 1.
DR Pfam; PF12859; ANAPC1; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR Pfam; PF21282; APC1_3rd; 1.
DR Pfam; PF12937; F-box-like; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF81383; F-box domain; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000258309};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..39
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT REGION 768..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1173..1196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 831..841
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1174..1188
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:RFU35438.1"
FT NON_TER 2637
FT /evidence="ECO:0000313|EMBL:RFU35438.1"
SQ SEQUENCE 2637 AA; 295426 MW; 35A8EFBD52BBBCBE CRC64;
MFLIRDLPDE LLIEIFSHFT HEKHMLQQLA LVCRRFHLLA LKLLVAHVEL HDLAAYAGNP
FPPKPNFDLF MRSVNENPGI ASMVRNLQLS WNQEKSKNHV WANELLGKLT SLQSLSIIAT
RLKTDPNFTE YKSLKYLSSV YLEDELLNLS DVVPYIFLKS IRHISIAYLQ NPYTLEDYDP
GSSPITSFEL GPEIFLPERV LEKILRWPRD LKRLTCHVPG YIFRRHPPYF KQMKNRFSPQ
SIQLALTPVA HSLVELDLKS DGTFWPAYDK TRLDLREFRV LERARIPSIL FFDQAPVTYS
EVLAKIQSHN QLYGYLPRSL VELRIDYDHF SPIFFYGNQW FDVPSDAEDL WPSQLVWIAE
LARHKQHCFP NFQLLQVKEG ESASQHFKTF QLTEEYLSPI QDDLRGSGYH QPTGLPYAIQ
ERLLPLDPSS SSYKWYNSSD GEADSSSDDD ELLVTSRCVI WSRGGCFRQC YQFDLENEPV
THALLTHFPT VDTPNKKDKN FVEKTSGPRF RSKALVVFLK TQAHVYFLSG SSHIIHLPFE
VEFAIAAPDG LILQRKLRFD TLAPTSLKFP RVPPNSFVSS QPQIWSAASS LQSTFSIADL
NAPKKLPIFP NPTLQDLWEP PVLNHDAKWP RLFSLSDPLS EMGLVVSQPS QPDAHKRSSI
KPTSLDTAEE ILYASRRSEL EIGTDENALI LVLTLNRETS MYTVWRMSYI GQGSPTAETK
HRISGTASRR RSSFIRGTAT GATTPVANNQ QSLRESFAGN TVILPKKAPK KVSSRTDKED
EFASTLDPDF ESGNVPRRKS RRVSSMLARA DLSASHERTG NIPSRRGDSL GGQNPRISSG
AFTNSQISQF SQSLNSFLEA PVDDLLDELR AGGDFEGFHN MGLEDEEFDG LRQEILLTKI
TSIAADHSNI RYSSQHIPAQ NKYKIFTLTT PLSASDDRQK NTIVICILDS DEKRLIVLTL
YKKSSKDQVH MAGILPNDTV DDRGVTIVTK GDPTRWKGVI DACRIDDGSI SRILVLTETP
DGQGELTLQA PWSELMKISL PNQFNIANLR NLGFDASFRA RREEGFRRVL SQGPLGFCGL
RNSRPRGIVD IVDNQGKSHQ VQILMEPRNP YAKKVLAMCR TVLCGPRNGE GILVGWWNAM
RWLETEYNDL IDKEWTAVVI TLFSLMFALG SASKPKHTRP HTKQKKSRSG FLRSSSGAQV
EIGSWETMQT SEASNGDPYP SWSHTTAWKW LTEPDRIDPS SNDPVLKISY GDKETFIRKH
VRLTREFVSS PIGEVAVSTC LPTAPSRTRN FESRSAALVD IITGLHLLRE EEKLNTTTID
ALASGTATLI PVVAQMAQWL GWTTWMSVYN LEDASLIDAI YDLRKAQSLL RIVQLLMCKA
DSPLDQQIVE PFDCPVILDW IRNTLVNQVP APFPTLNDII SRRSTQVSMQ VLAKDTSRSL
TPRTYSFEQF FQSRRKNWSA ADFVEGLATA GINSSVLDTL PESVLATLME AIVQCQSEPP
SSWDKDLLAL VGREDVNLLL APGQHSRGSN YTILAPSHES NLDVHTICES VDDVESNIDS
FDGSAGPSRQ LITRAIFRDD RRMDEAINIM NTFRPTIARC RIEPDWTDSE LLEAQKEHVQ
MLAYRTLAIP AGRDKMAFTE DKICWPFFHA GVAAGLSISP NASGIDTSWI LYNKPAQDLS
NRHAGFLLAL GLNGHLKTLA KWVAFKYLTP KHTMTSIGLL LGLAASYIGT MDSLVTRLLS
VHVTRMLPPG AAELNLSPLT QTTGILGIGL VYCNTQHRRM SEIMVTEIEH IDQEMDEPLR
NECYRLAAGF ALGLINLGKG SDLKGLHDMR LTDRLLTLAA GNKKIDLVHV LDKATAAAVI
AIALIFMKSE DQILARKIDI PDSIVQFDYV RPDMFLLRTL AKHLIMWNKI EPTYTWIQDG
LPAPFKKKGK LDSIRDLTSE DLPFYNIITG LCFSIALRYA GSGSIVARDL LIHYLDQMMR
ICQIPADSYD KKLTRNTIRT CQDMLALGSA SVMAGTGDLI VLRRLRSLHG RDDSETPYGS
HLAAHLAIGC LFLAGGTHTF GTSNIAVASL LLAFYPIFPY TVQDNKSHLQ AFRHFWVLAV
EPRCLVARDI DTNQPVPLPL TINLKNNGSF QCTTPCLLPE LDQIQTVRTN STEYWNIVLD
LQNNPTHIAS FKATQTIYVR RRLAHDSTTS AFQATIQALN GVNGAAIPSL EWIFELPVFS
TLTKAERALV LPPDNGGASD IHAGTSQTVV DSRLVLENIT LDSGKRDRLL GLKLLVEWSN
KAMDEGRDMQ WISAGAVGTV GALSIETGGF GSVTAVLRSN YEAVVKSGFK IDSIDHGHLT
GWRPTKVVNS IPDVVKENLT PFDYIVCTTK NCPDIPPSLA SLIGPAVTPG HTVIVLVQNG
LNIERPLFAA FPSNIVLSGI SMIDAFEKEK GWIVHEFEDQ LIIGAWSNPN FDEEGKKKEL
EKAKEFMKIY RGSEGEGVDR PKGRPDVRLC KTSEDVQWYR WRKLVFNSAL NPICAITRLD
DARIRLADGA ADGLVRPAMR EIIAVSAKLG YVLPEDIAET MINMDPIDLY LKPSMLVDAE
KGNFLEFENL VGEPLREAEK AGVDTPTLRV IYYMCKALQW RTKEERGLVT VPPKRHI
//
