ID A0A3E3K3N7_9FIRM Unreviewed; 638 AA.
AC A0A3E3K3N7;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 28-JAN-2026, entry version 28.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:RGE88047.1};
GN ORFNames=DW016_06290 {ECO:0000313|EMBL:RGE88047.1};
OS Sellimonas intestinalis.
OC Bacteria; Bacillati; Bacillota; Clostridia; Lachnospirales;
OC Lachnospiraceae; Sellimonas.
OX NCBI_TaxID=1653434 {ECO:0000313|EMBL:RGE88047.1, ECO:0000313|Proteomes:UP000261080};
RN [1] {ECO:0000313|EMBL:RGE88047.1, ECO:0000313|Proteomes:UP000261080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF37-2AT {ECO:0000313|EMBL:RGE88047.1,
RC ECO:0000313|Proteomes:UP000261080};
RA Zou Y., Xue W., Luo G.;
RT "A genome reference for cultivated species of the human gut microbiota.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RGE88047.1}.
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DR EMBL; QVLX01000003; RGE88047.1; -; Genomic_DNA.
DR RefSeq; WP_024731837.1; NZ_BAABYU010000001.1.
DR AlphaFoldDB; A0A3E3K3N7; -.
DR OrthoDB; 9804504at2; -.
DR Proteomes; UP000261080; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:RGE88047.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000261080}.
FT DOMAIN 1..173
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 638 AA; 72103 MW; 34A99E279389E898 CRC64;
MKHIIIGTAG HIDHGKTTLI KALTGRNTDR WEEEQRRGIT IDLGFTYFDL PNGDRAGIID
VPGHERFINN MVAGVVGMDL VMLVIAADEG IMPQTREHMD ILGELGIEKS IIVLNKCDLV
DEEWLELVEE EIRDELKGTF LEFAPVVKVS AATGEGLSKL VNMIQKMTEN EVTEKDIHTI
PRLPIDRVFT MSGFGTIITG TLLAGTIRRE DTLCMYPNGK ECKIRSIQVH GESVDVCYAG
QRVAINLSNI KKSEIHRGCV LAPPKNMKNT DLLDVRLNVL PSSMRILVNN SRLHLFTGTS
EVLCRAVLLD KEEIGPGESG FVQLRLEEEI AVRRGDRFVV RFYSPMETIG GGVILEPNPK
WKKRFQPDVI EELRQKESGS SADVIELHIR QHEKDMVSVS ELAKITALSL EEVEEDIKEL
REEGRISVFP MKKETYVWHI SSQESITAAI REELRAFHSA HPYRPGIPKA EVHMRFMKQV
KPNVFDLYIE MLTEEGKIGR SGEYLHSADY MIPKDAEFEK ASRTILEALE KAGYDFVRFS
EITFPKLSEG TKEDVLQVLI SEGAVVKIND EMYTLADYME QAKEKIKKKL AKDGMITIAE
VRDMFHTSRK SAKPILEYMD GQKVTKKTGA ESERVAYL
//
