ID A0A3F2YNR7_MOUSE Unreviewed; 439 AA.
AC A0A3F2YNR7;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 28-JAN-2026, entry version 36.
DE RecName: Full=Transcriptional enhancer factor TEF-5 {ECO:0000256|PIRNR:PIRNR002603};
GN Name=Tead3 {ECO:0000313|Ensembl:ENSMUSP00000152030.3,
GN ECO:0000313|MGI:MGI:109241};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000152030.3, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000152030.3, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000152030.3,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RG Mouse Genome Sequencing Consortium;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000152030.3, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000152030.3,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=21750661;
RA Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N.,
RA Chen H.C., Agarwala R., McLaren W.M., Ritchie G.R., Albracht D.,
RA Kremitzki M., Rock S., Kotkiewicz H., Kremitzki C., Wollam A., Trani L.,
RA Fulton L., Fulton R., Matthews L., Whitehead S., Chow W., Torrance J.,
RA Dunn M., Harden G., Threadgold G., Wood J., Collins J., Heath P.,
RA Griffiths G., Pelan S., Grafham D., Eichler E.E., Weinstock G.,
RA Mardis E.R., Wilson R.K., Howe K., Flicek P., Hubbard T.;
RT "Modernizing reference genome assemblies.";
RL PLoS Biol. 9:e1001091-e1001091(2011).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000152030.3}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000152030.3};
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [4] {ECO:0000313|Ensembl:ENSMUSP00000152030.3}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000152030.3};
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- FUNCTION: Transcription factor which plays a key role in the Hippo
CC signaling pathway, a pathway involved in organ size control and tumor
CC suppression by restricting proliferation and promoting apoptosis.
CC {ECO:0000256|PIRNR:PIRNR002603}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR002603}.
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DR AlphaFoldDB; A0A3F2YNR7; -.
DR SMR; A0A3F2YNR7; -.
DR jPOST; A0A3F2YNR7; -.
DR Antibodypedia; 6662; 263 antibodies from 31 providers.
DR Ensembl; ENSMUST00000219703.3; ENSMUSP00000152030.3; ENSMUSG00000002249.22.
DR AGR; MGI:109241; -.
DR MGI; MGI:109241; Tead3.
DR VEuPathDB; HostDB:ENSMUSG00000002249; -.
DR GeneTree; ENSGT00950000182956; -.
DR Proteomes; UP000000589; Chromosome 17.
DR Bgee; ENSMUSG00000002249; Expressed in lip and 221 other cell types or tissues.
DR ExpressionAtlas; A0A3F2YNR7; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:UniProtKB-ARBA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0035329; P:hippo signaling; IEA:UniProtKB-UniRule.
DR GO; GO:1902459; P:positive regulation of stem cell population maintenance; IEA:UniProtKB-ARBA.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR FunFam; 2.70.50.80:FF:000001; Transcriptional enhancer factor TEF-1, putative; 1.
DR Gene3D; 2.70.50.80; -; 1.
DR Gene3D; 6.10.20.40; TEA/ATTS domain; 1.
DR InterPro; IPR000818; TEA/ATTS_dom.
DR InterPro; IPR038096; TEA/ATTS_sf.
DR InterPro; IPR050937; TEC1_TEAD_TF.
DR InterPro; IPR027253; TEF-5.
DR InterPro; IPR016361; TEF_metazoa.
DR InterPro; IPR041086; YBD.
DR PANTHER; PTHR11834; TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED; 1.
DR PANTHER; PTHR11834:SF7; TRANSCRIPTIONAL ENHANCER FACTOR TEF-5; 1.
DR Pfam; PF01285; TEA; 1.
DR Pfam; PF17725; YBD; 1.
DR PIRSF; PIRSF002603; TEF; 1.
DR PIRSF; PIRSF500720; TEF-5; 1.
DR PRINTS; PR00065; TEADOMAIN.
DR SMART; SM00426; TEA; 1.
DR PROSITE; PS51088; TEA_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR002603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR002603};
KW Proteomics identification {ECO:0007829|ProteomicsDB:A0A3F2YNR7};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR002603};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR002603}.
FT DOMAIN 28..104
FT /note="TEA"
FT /evidence="ECO:0000259|PROSITE:PS51088"
FT DNA_BIND 28..104
FT /note="TEA"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00505"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..12
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 439 AA; 48967 MW; 2D2BE49FF1FE52AC CRC64;
MASNSWTANS SPGEAREDGS EGLDKGLDND AEGVWSPDIE QSFQEALAIY PPCGRRKIIL
SDEGKMYGRN ELIARYIKLR TGKTRTRKQV CSHLQVLARR KSRETQSKLK AMNLDQVSKD
KALQSMASMS SAQIVSASVL QNKFSPPSPL PQAVFSSSSR FWSSPPLLGQ QPGPSQDIKP
FAQPAYPIQP PLPPALNSYE SLAPLPPAAA SATASAPAWQ DRTIASSRLR LLEYSAFMEV
QRDPDTYSKH LFVHIGQTNP AFSDPPLEAV DVRQIYDKFP EKKGGLKELY EKGPPNAFFL
VKFWADLNST IQEGPGAFYG VSSQYSSADS MTISVSTKVC SFGKQVVEKV ETEYARLENG
RFVYRIHRSP MCEYMINFIH KLKHLPEKYM MNSVLENFTI LQVVTSRDSQ ETLLVIAFVF
EVSTSEHGAQ HHVYKLVKD
//
