ID   A0A3L6RD99_PANMI        Unreviewed;       872 AA.
AC   A0A3L6RD99;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   05-FEB-2025, entry version 27.
DE   RecName: Full=Anaphase-promoting complex subunit 5 {ECO:0000256|ARBA:ARBA00016066};
DE   AltName: Full=Cyclosome subunit 5 {ECO:0000256|ARBA:ARBA00031069};
GN   ORFNames=C2845_PM06G34770 {ECO:0000313|EMBL:RLN00799.1};
OS   Panicum miliaceum (Proso millet) (Broomcorn millet).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Panicodae; Paniceae; Panicinae; Panicum.
OX   NCBI_TaxID=4540 {ECO:0000313|EMBL:RLN00799.1, ECO:0000313|Proteomes:UP000275267};
RN   [1] {ECO:0000313|Proteomes:UP000275267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=30683860; DOI=10.1038/s41467-019-08409-5;
RA   Zou C., Miki D., Li D., Tang Q., Xiao L., Rajput S., Deng P., Jia W.,
RA   Huang R., Zhang M., Sun Y., Hu J., Fu X., Schnable P.S., Li F., Zhang H.,
RA   Feng B., Zhu X., Liu R., Schnable J.C., Zhu J.-K., Zhang H.;
RT   "The genome of broomcorn millet.";
RL   Nat. Commun. 10:436-436(2019).
CC   -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC       (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC       progression through mitosis and the G1 phase of the cell cycle. The
CC       APC/C complex acts by mediating ubiquitination and subsequent
CC       degradation of target proteins: it mainly mediates the formation of
CC       'Lys-11'-linked polyubiquitin chains and, to a lower extent, the
CC       formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The
CC       APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked
CC       branched ubiquitin chains on target proteins.
CC       {ECO:0000256|ARBA:ARBA00045696}.
CC   -!- SIMILARITY: Belongs to the APC5 family.
CC       {ECO:0000256|ARBA:ARBA00007450}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RLN00799.1}.
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DR   EMBL; PQIB02000009; RLN00799.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3L6RD99; -.
DR   STRING; 4540.A0A3L6RD99; -.
DR   OrthoDB; 2504561at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000275267; Chromosome 6.
DR   GO; GO:0005680; C:anaphase-promoting complex; IEA:InterPro.
DR   GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IEA:TreeGrafter.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0045842; P:positive regulation of mitotic metaphase/anaphase transition; IEA:TreeGrafter.
DR   GO; GO:0070979; P:protein K11-linked ubiquitination; IEA:TreeGrafter.
DR   CDD; cd16270; Apc5_N; 1.
DR   InterPro; IPR037679; Apc5.
DR   InterPro; IPR026000; Apc5_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_rpt.
DR   PANTHER; PTHR12830; ANAPHASE-PROMOTING COMPLEX SUBUNIT 5; 1.
DR   PANTHER; PTHR12830:SF9; ANAPHASE-PROMOTING COMPLEX SUBUNIT 5; 1.
DR   Pfam; PF12862; ANAPC5; 1.
DR   SMART; SM00028; TPR; 2.
DR   SUPFAM; SSF48452; TPR-like; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW   Reference proteome {ECO:0000313|Proteomes:UP000275267};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          309..409
FT                   /note="Anaphase-promoting complex subunit 5"
FT                   /evidence="ECO:0000259|Pfam:PF12862"
SQ   SEQUENCE   872 AA;  95521 MW;  EB6067D22C2154B5 CRC64;
     MSLFAGVGGG AGVADPASAG GTGRALLELT PHKIAVCHLV QVFAPPAQAG GDSVPPFPFE
     SVAHHNRLGL FLFMLTRSCD DFREPSLEEL LRQLKAVDDL TNGWLCEQLT STLSVLNSPD
     DLFNFFDKLR AVLTAPEGAS AEDIFLDPNS QLGVFLRCCI LAFNSMTFEG VCHLLADLVM
     YCNSTDASYD LAEDEDFDTE MNNLMDADIS SQAGIFEKYR QGYASESHMG ESSSALTRAP
     MSLHDFDEAN NFEADDNPTC LRSRWQLEAY LNQQADILEK DPSSVPLNSF NATMTQLQTL
     APELHRVQFL QYLNALCHDD YVASLDNLHR YFDYSAGMQG LFGRSVSPVQ DIVVGKYESA
     LLCLGNLHCY FGHPKKALEA FAEAVRVSQM NNDDSCLAYV LGAISNLLSK IGMSNTVGII
     SSPYSLGTNI GLGTPLSIQQ QLLVLLKRSL KRADILKLPS LLSFDHLSLA KFELKHVQRP
     LVSFGPNAST KLRTCPSDVC KNLRLSTRVL TDFGTDALST SNDNGSFSTS WLRNLSAASD
     SWRSSSMKST KLHNDFDNFH YHAQPSPVPA PVLQLAGSGY LLRATAWEHY GSAPMVRMNA
     LVYATSFADA ARWECAAFCA LKLAEKKFPS STSLHIQLLR MQILHERALH RGHLKVAQQI
     CDEFGVLSSS VCGVDIMAAA VANSLFSTCY KYNMQVENAS VLLLLAEIHT KSDNAVLGLP
     CALASQSFCK SFNLDLLEAS ATLTLAELWL ALGSSHAERA LSLVHQSLPM ILGHGGLELC
     ARAHIVLAKC HLSDPKFSVP EDPEAVLDPL NQATQDLQAL EYHEMAAEAY YLKAMAYNHL
     GKLNEREEAA ACFREHITAL ENPHNEEDSL AY
//