ID A0A3L8Q7A5_CHLGU Unreviewed; 450 AA.
AC A0A3L8Q7A5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 02-APR-2025, entry version 28.
DE RecName: Full=BHLH domain-containing protein {ECO:0000259|PROSITE:PS50888};
GN ORFNames=DV515_00018539 {ECO:0000313|EMBL:RLV63175.1}, DV515_00018540
GN {ECO:0000313|EMBL:RLV63174.1};
OS Chloebia gouldiae (Gouldian finch) (Erythrura gouldiae).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Passeroidea; Passeridae; Chloebia.
OX NCBI_TaxID=44316 {ECO:0000313|EMBL:RLV63175.1, ECO:0000313|Proteomes:UP000276834};
RN [1] {ECO:0000313|EMBL:RLV63175.1, ECO:0000313|Proteomes:UP000276834}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Red01 {ECO:0000313|EMBL:RLV63175.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:RLV63175.1};
RX PubMed=30282656;
RA Toomey M.B., Marques C.I., Andrade P., Araujo P.M., Sabatino S.,
RA Gazda M.A., Afonso S., Lopes R.J., Corbo J.C., Carneiro M.;
RT "A non-coding region near Follistatin controls head colour polymorphism in
RT the Gouldian finch.";
RL Proc. R. Soc. B 285:0-0(2018).
RN [2] {ECO:0000313|EMBL:RLV63175.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Red01 {ECO:0000313|EMBL:RLV63175.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:RLV63175.1};
RA Sabatino S.J.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MiT/TFE family.
CC {ECO:0000256|ARBA:ARBA00008289}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RLV63175.1}.
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DR EMBL; QUSF01003571; RLV63174.1; -; Genomic_DNA.
DR EMBL; QUSF01003570; RLV63175.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3L8Q7A5; -.
DR STRING; 44316.ENSEGOP00005020932; -.
DR Ensembl; ENSEGOT00005023952; ENSEGOP00005020932; ENSEGOG00005016785.
DR Ensembl; ENSEGOT00005023960; ENSEGOP00005020939; ENSEGOG00005016790.
DR Ensembl; ENSEGOT00005024455; ENSEGOP00005021342; ENSEGOG00005017165.
DR OMA; RPCHAMP; -.
DR OrthoDB; 6242697at2759; -.
DR Proteomes; UP000276834; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006959; P:humoral immune response; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd18927; bHLHzip_TFEB; 1.
DR FunFam; 4.10.280.10:FF:000003; microphthalmia-associated transcription factor isoform X1; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR024098; bHLHzip_TFEB.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR021802; MiT/TFE_C.
DR InterPro; IPR031867; MiT/TFE_N.
DR PANTHER; PTHR45776; MIP04163P; 1.
DR PANTHER; PTHR45776:SF5; TRANSCRIPTION FACTOR EB; 1.
DR Pfam; PF11851; DUF3371; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF15951; MITF_TFEB_C_3_N; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000276834};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 230..283
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 101..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 342..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 428..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..138
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..373
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..443
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 450 AA; 49960 MW; 77F6F5D3B16186EB CRC64;
MASRIGLRME LMKQQAQQEA ERERVQQQMM MSYMQQQRMP VASSPAINTP VHFQSPPPVP
GEVLKVQSYL ENPTTYHLQK SRDKKVQAYL SETYGNKFAA HVSPASHSPK PPPAASPGGV
RPGHVLSSSA GNSAPNSPMA MLNIGSNPER EFDEVIDDIM RLDDVLGYMN PEVHMPNTLP
MSSSHMNVYS GDPQVTASLV GVTSSSCPAD LTQKRELTDA ESRALAKERQ KKDNHNLIER
RRRFNINDRI KELGMLIPKA NDLDVRWNKG TILKASVDYI KRMQKDLQRS RDLENHSRRL
EMANKQLLLR IQELEMQARV HGLPTSSPSG VNVAELAQQV VKQEGSGDEG TLEPLLPPPD
PESQPALPAP PQSPYHQLDF THSLSFDDGS QGFPDSASFP SLSKKELDLM LMQDTMLPLA
SDPLFSAMSP EASKASSRRS SFSMEDADML
//
