ID A0A3M0J9Y5_HIRRU Unreviewed; 1752 AA.
AC A0A3M0J9Y5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 18-JUN-2025, entry version 29.
DE RecName: Full=Non-specific serine/threonine protein kinase {ECO:0008006|Google:ProtNLM};
GN ORFNames=DUI87_25465 {ECO:0000313|EMBL:RMB97987.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Sylvioidea; Hirundinidae; Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMB97987.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMB97987.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMB97987.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMB97987.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMB97987.1}.
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DR EMBL; QRBI01000154; RMB97987.1; -; Genomic_DNA.
DR STRING; 333673.A0A3M0J9Y5; -.
DR OrthoDB; 248495at2759; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:TreeGrafter.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0051754; P:meiotic sister chromatid cohesion, centromeric; IEA:TreeGrafter.
DR GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:InterPro.
DR CDD; cd01093; CRIB_PAK_like; 1.
DR FunFam; 1.25.40.430:FF:000002; mitotic checkpoint serine/threonine-protein kinase BUB1 beta; 1.
DR FunFam; 1.10.510.10:FF:000768; Non-specific serine/threonine protein kinase; 1.
DR FunFam; 3.30.200.20:FF:000141; Non-specific serine/threonine protein kinase; 1.
DR Gene3D; 1.25.40.430; -; 1.
DR Gene3D; 3.30.200.20; Phosphorylase Kinase, domain 1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR015661; Bub1/Mad3.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR013212; Mad3/Bub1_I.
DR InterPro; IPR033923; PAK_BD.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR PANTHER; PTHR14030; MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1; 1.
DR PANTHER; PTHR14030:SF25; MITOTIC CHECKPOINT SERINE_THREONINE-PROTEIN KINASE BUB1 BETA; 1.
DR Pfam; PF08311; Mad3_BUB1_I; 1.
DR Pfam; PF00786; PBD; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00777; Mad3_BUB1_I; 1.
DR SMART; SM00285; PBD; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR PROSITE; PS51489; BUB1_N; 1.
DR PROSITE; PS50108; CRIB; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000269221};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 197..364
FT /note="BUB1 N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51489"
FT DOMAIN 673..1075
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1075..1088
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT DOMAIN 1508..1752
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 430..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 584..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1226..1252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1287..1483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 584..599
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1294..1318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1441..1455
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1456..1467
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 1537
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1752 AA; 195562 MW; 4987AD4A158990DF CRC64;
MSVSPVKRQK MESALDQLKH HTTVVADTGD FNELIKENIL HLAEEDELTG IERLSEDAIV
SGSYKNKSLC ANPEDTCDFN RAAHLASTPF HGVVAQRVPA PAFCPSELKE DSPESKSAPL
SQETPVCEGA FTESLSVKKL RIKGEVVMSE EDGHEWELSK ENVQPLRHGR VMSSLQEALA
QQDCSSHTAV QLKKQEFEAE IRFYSGDDPL DVWERYIKWT EQAFPGGGKD GNLAAVLERA
VRALHGQQRY YKDPRYLNLW LKFGDCCNEP LDLYSYLCSQ EIGTTLALLY ITWAEALEAR
GSFRKADLIF QEGLQRKAEP LDKLQAHHKQ FQARVSRQTL LALEENSDGD NMGLLEIAEP
QRSSLADLKG RGKKKVRAPI SRVGDAVKVM NPNRSCQPQT SQQLPNAPSF AVFDENSVSG
PEIATLTAQS WPAPPVPKAK ENELSAGPWN SGRRPRSTVS SGVEVPQPLP SFTPYVEESA
QPQMMTPCKI EPSINSVLST RKPGEREDPL QRVQHQQQDA QAKKEMVMYC KEKVYAGVDE
FSFEEIRAEI YRKKAKKKDE DEIQAIERKK EEIQRKIEEL EKKLKKKEDD KQQQPHEQDE
LTGIERLSED AIVSGSYKNK SLCANPEDTC DFNRAAHLAS TPFHGVVAQR VPAPAFCPSE
LKEDSPESKS APLSQETPVC EGAFTESLSV KKLSPIMEAS LEDTRSSGSS VSGGSLSSVT
QMSAIKYLHI SDKLELAHSL PAEVGIDSGG GNVSEDDVTQ FPWSPEQRKK LLDPMLSSLV
ASPDFHLETG ALPHMEVEKD VELGNETYCI KMEYWNNEEY KMFFAIPTGC IFQWDAKGYA
VKVYSQPVPW DFYITLELQK RLDSDFDQSF SENCSCYLYQ DGCAIVHKDT NCFTLRDVLC
DRKFITKEIL FLVVHDLLHM VEKLHKAEIV HGDLRPEVLF LGDRICDAFS DEEVPNALKM
VDFSHSLDLR VLPRVSLPYN FPTAQTPHGQ QLLAESSLPY QVDLVGIADI VHLMLFGDHI
QVYQENSIWK ISQNLSMTPD SDFWSKLFER ILNADGSKRG DGIMFRKKKK KRPEISAPQN
FEHRVHTSFD PKEGKFVGLP PQWQNILDTL RRPKPVVDPS RITRMQLQPM KALSKPGARL
CTVVVFSVEI AGATVLHQLS IRLSVINSTC LEDPWSSVSK QEIAVTPGKD FPQAKTVVRG
STVEVEGYIS GLLNDIQKLS AISSNTLRGR SPTSRRRAQS LGLLGDERPP DMYLQSPEGD
WADKYGNYLN CNGGSKVARR QTMWPDYKSR SEGQSHPNGM VTKAQSLGPS EFQGTDGSCL
QRASGLNESE TAMKSPEEGW HQRQPNARPS GEGSPGSKSR ENSLKRRLLR SVFPSSSTSN
KPGPPVQVKP NAFFKPQQWG SPHSPAAKAQ SLPPDQPASE FPRMISEAGT PQKSPTAEKA
VAVPPGRPSP AGSPRNRQTQ TSSSNLHLPQ DSAGKGQPTS EDPVVVTHEQ FKAALRMVVD
QGDPRTLLEN YIKIGEGSTG IVCIAREKHS GRQVAVKMMD LRKQQRRELL FNEVVIMRDY
QHVNVVEMYK SYLVGEELWV LMEFLQGGAL TDIVSQIRLN EEQIATVCES VLQALSYLHS
QGVIHRDIKS DSILLTLDGR VKLSDFGFCA QISKDVPKRK SLVGTPYWMA PEVIARIPYT
TEVDIWSLGI MVIEMVDGEP PYFSDSPVQA MKRLRDSPPP KLKNFHRGET LGYGPQSGLC
EDQVILPPES YG
//
