ID A0A3M0JBP8_HIRRU Unreviewed; 644 AA.
AC A0A3M0JBP8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 02-APR-2025, entry version 26.
DE RecName: Full=Agenet-like domain-containing protein {ECO:0000259|PROSITE:PS51641};
GN ORFNames=DUI87_25268 {ECO:0000313|EMBL:RMB98362.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Sylvioidea; Hirundinidae; Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMB98362.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMB98362.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMB98362.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMB98362.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, Cytoplasmic ribonucleoprotein granule
CC {ECO:0000256|ARBA:ARBA00004331}.
CC -!- SIMILARITY: Belongs to the FMR1 family.
CC {ECO:0000256|ARBA:ARBA00006633}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMB98362.1}.
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DR EMBL; QRBI01000153; RMB98362.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M0JBP8; -.
DR STRING; 333673.A0A3M0JBP8; -.
DR OrthoDB; 424249at2759; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:TreeGrafter.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0043005; C:neuron projection; IEA:TreeGrafter.
DR GO; GO:0005634; C:nucleus; IEA:TreeGrafter.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IEA:TreeGrafter.
DR GO; GO:0045182; F:translation regulator activity; IEA:TreeGrafter.
DR GO; GO:0048513; P:animal organ development; IEA:TreeGrafter.
DR GO; GO:0051028; P:mRNA transport; IEA:TreeGrafter.
DR GO; GO:0048170; P:positive regulation of long-term neuronal synaptic plasticity; IEA:TreeGrafter.
DR GO; GO:0045727; P:positive regulation of translation; IEA:TreeGrafter.
DR GO; GO:0043488; P:regulation of mRNA stability; IEA:TreeGrafter.
DR GO; GO:0099577; P:regulation of translation at presynapse, modulating synaptic transmission; IEA:TreeGrafter.
DR CDD; cd22506; KH_I_FMR1_rpt1; 1.
DR CDD; cd22509; KH_I_FMR1_rpt2; 1.
DR CDD; cd22512; KH_I_FMR1_rpt3; 1.
DR CDD; cd20471; Tudor_Agenet_FMR1_rpt1; 1.
DR FunFam; 2.30.30.140:FF:000002; Fragile X mental retardation 1, isoform CRA_e; 1.
DR FunFam; 3.30.1370.10:FF:000004; Fragile X mental retardation 1, isoform CRA_e; 1.
DR FunFam; 3.30.1370.10:FF:000034; synaptic functional regulator FMR1 isoform X2; 1.
DR Gene3D; 2.30.30.140; -; 2.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR InterPro; IPR040148; FMR1.
DR InterPro; IPR022034; FMR1-like_C_core.
DR InterPro; IPR040472; FMRP_KH0.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR047438; KH_I_FMR1_rpt1.
DR InterPro; IPR047440; KH_I_FMR1_rpt2.
DR InterPro; IPR047431; Tudor_Agenet_FMR1_rpt1.
DR InterPro; IPR041560; Tudor_FRM1.
DR PANTHER; PTHR10603; FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN; 1.
DR PANTHER; PTHR10603:SF4; FRAGILE X MESSENGER RIBONUCLEOPROTEIN 1; 1.
DR Pfam; PF12235; FXMRP1_C_core; 1.
DR Pfam; PF00013; KH_1; 2.
DR Pfam; PF17904; KH_9; 1.
DR Pfam; PF18336; Tudor_FRX1; 1.
DR SMART; SM00322; KH; 2.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2.
DR PROSITE; PS51641; AGENET_LIKE; 1.
DR PROSITE; PS50084; KH_TYPE_1; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000269221};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00117}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 580..606
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4..50
FT /note="Agenet-like"
FT /evidence="ECO:0000259|PROSITE:PS51641"
FT REGION 394..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..436
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 644 AA; 72766 MW; 2453E206EE94FBE3 CRC64;
MEELVVEVRG SNGAFYKAFV KDVHEDSITV SFENNWQPER QIPFHDVRFP PPAGYNKDIN
ESDEVEFYVI EYAACDATYN EIVTIERLRS VNPNKPATKD TFHKIKLAVP EDLRQMCAKE
SAHKDFKKAV GAFSVTYDSE NHQLIILSIN DVTTKRANML IDMHFRSLRT KLSLILRNEE
ASKQLESSRQ LASRFHEQFV VREDLMGLAI GTHGANIQQA RKVPGVTAID LDEDTCTFHI
YGEDQDAVKK ARSYLEFAED VIQVPRNLVG KVIGKNGKLI QEIVDKSGVV RVRIEAENDK
NIPQEELSIH TSVSPVNDIS KTGTACAASC VSCVMPGAIQ TPEIRLKQGM VPFVFVGTKD
SITNATVLLD YHLNYLKEVD QLRLERLQID EQLRQIGATS RPPPNRTDKD KGYMTDDGPG
LGRGSRPYRN RGHSRRGPGY ASEQDNIVIY MFIEKDQAKA MTNSREQITV SVTRERRRGG
QQTGLLRLNH PRSQLVFRAE LFQASGHLHD PLDKFEKVHV LHMVKLQPAA PACRLSTQRL
LTPCPVEGLN MSECSKIRCC PFRIGHDEQC YMPVRDDVQL AIRVILLTGG GFLSLGFFPI
VCCAVLQRRN IHLILKIEQK TPGLFDYLLE NGTLYFNIEE IQSC
//
