ID A0A3M0JZS1_HIRRU Unreviewed; 349 AA.
AC A0A3M0JZS1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 08-OCT-2025, entry version 17.
DE RecName: Full=Platelet-derived growth factor (PDGF) family profile domain-containing protein {ECO:0000259|PROSITE:PS50278};
GN ORFNames=DUI87_15867 {ECO:0000313|EMBL:RMC06433.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Sylvioidea; Hirundinidae; Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMC06433.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMC06433.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMC06433.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMC06433.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC {ECO:0000256|RuleBase:RU003818}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMC06433.1}.
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DR EMBL; QRBI01000120; RMC06433.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M0JZS1; -.
DR STRING; 333673.A0A3M0JZS1; -.
DR OrthoDB; 198735at2759; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0042056; F:chemoattractant activity; IEA:TreeGrafter.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005172; F:vascular endothelial growth factor receptor binding; IEA:TreeGrafter.
DR GO; GO:0050930; P:induction of positive chemotaxis; IEA:TreeGrafter.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:TreeGrafter.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:TreeGrafter.
DR GO; GO:0060754; P:positive regulation of mast cell chemotaxis; IEA:TreeGrafter.
DR GO; GO:0001666; P:response to hypoxia; IEA:TreeGrafter.
DR GO; GO:0002040; P:sprouting angiogenesis; IEA:TreeGrafter.
DR GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:TreeGrafter.
DR GO; GO:0038084; P:vascular endothelial growth factor signaling pathway; IEA:TreeGrafter.
DR CDD; cd00135; PDGF; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR023581; PD_growth_factor_CS.
DR InterPro; IPR000072; PDGF/VEGF_dom.
DR InterPro; IPR050507; PDGF/VEGF_growth_factor.
DR PANTHER; PTHR12025; VASCULAR ENDOTHELIAL GROWTH FACTOR; 1.
DR PANTHER; PTHR12025:SF11; VASCULAR ENDOTHELIAL GROWTH FACTOR D; 1.
DR Pfam; PF00341; PDGF; 1.
DR SMART; SM00141; PDGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00249; PDGF_1; 1.
DR PROSITE; PS50278; PDGF_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU003818};
KW Reference proteome {ECO:0000313|Proteomes:UP000269221}.
FT DOMAIN 169..268
FT /note="Platelet-derived growth factor (PDGF) family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50278"
SQ SEQUENCE 349 AA; 39889 MW; 51D57C62F92B457C CRC64;
MLFLSSEMKY SVVIKLLHAN MCQTCGRVRS LMIDIYGVMQ LLVDSARTSL SALERSEQQI
RRASSLEELL HITHSEDWKL WKCRLKLKSL ANLDSRSASH RSTRFAAAFY DIDTLKGLEH
PSPEVRLREL GLFSLEKRRF HGDLNAAFQY LIGSFKRAGE GFSQGHAVKL KDVIDEEWQK
TQCVPRETCV EVAKELGTTT NKFFKPPCVN VFRCGGCCNE ESLSCMNTST TYVSKTLFEI
SVPLTSVPEP VPIKIANHTA CKCTSNTQRH QYTIIRRSVQ YPEEDGCPFT NKFCHNGWIW
DSDKCECVID TQHSDRREGC QQFPKQCVGS IAVFDDEKVE EYDTEEFSY
//
