ID A0A3M0L419_HIRRU Unreviewed; 723 AA.
AC A0A3M0L419;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 02-APR-2025, entry version 25.
DE RecName: Full=Receptor-type tyrosine-protein phosphatase-like N {ECO:0008006|Google:ProtNLM};
GN ORFNames=DUI87_04519 {ECO:0000313|EMBL:RMC18624.1};
OS Hirundo rustica rustica.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
OC Passeriformes; Sylvioidea; Hirundinidae; Hirundo.
OX NCBI_TaxID=333673 {ECO:0000313|EMBL:RMC18624.1, ECO:0000313|Proteomes:UP000269221};
RN [1] {ECO:0000313|EMBL:RMC18624.1, ECO:0000313|Proteomes:UP000269221}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Chelidonia {ECO:0000313|EMBL:RMC18624.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RMC18624.1};
RA Formenti G., Chiara M., Poveda L., Francoijs K.-J., Bonisoli-Alquati A.,
RA Canova L., Gianfranceschi L., Horner D.S., Saino N.;
RT "A high quality draft genome assembly of the barn swallow (H. rustica
RT rustica).";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004212}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004212}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 8 subfamily. {ECO:0000256|ARBA:ARBA00025723}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RMC18624.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; QRBI01000096; RMC18624.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M0L419; -.
DR STRING; 333673.A0A3M0L419; -.
DR OrthoDB; 9880441at2759; -.
DR Proteomes; UP000269221; Unassembled WGS sequence.
DR GO; GO:0030141; C:secretory granule; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0035773; P:insulin secretion involved in cellular response to glucose stimulus; IEA:TreeGrafter.
DR GO; GO:0051046; P:regulation of secretion; IEA:TreeGrafter.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR Gene3D; 3.30.70.2470; Protein-tyrosine phosphatase receptor IA-2 ectodomain; 1.
DR InterPro; IPR033522; IA-2/IA-2_beta.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR021613; Receptor_IA-2_dom.
DR InterPro; IPR038112; Receptor_IA-2_ectodomain_sf.
DR InterPro; IPR029403; RESP18_dom.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46106; IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C; 1.
DR PANTHER; PTHR46106:SF1; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE-LIKE N; 1.
DR Pfam; PF11548; Receptor_IA-2; 1.
DR Pfam; PF14948; RESP18; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SMART; SM01305; RESP18; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000269221};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 359..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 493..713
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 632..704
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 172..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 429..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..196
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..216
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..461
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 723 AA; 80184 MW; E3D792F47AC1472A CRC64;
MESEWADVPC CLFDRRLCSP QEVCVQDGLF GQCQVGSVQD RPYFQVTSPV LQRLQDVLRH
LMAQGLSWQD GITQYVISQE MERIPRLRLP PSLEPAARDR FLPLRSEPRR APLAPDPGLP
AAQHLELPPP LLLSPLVQRY LEHVLLPSPP QLGYEEALLN PYSYHKVMEG DMQHGEEPVP
PFSTVPSPKI PVSSSPGDGT KGRAASSPAP QAEPQQGHGG DALSPRKHIV VEKKSYTEMK
QSGAQQGMRP LDEYGYIVTD QKPLGLAAGV QLLELLAKHL HLSTASFINI SVVGPALTFR
IRQNPQNFSL ADVASQTEQV KGELEHELGL KIVQTGVGER NEAAAYSRPS RFGDGFHSVL
LTFIALACVA VIAIAVSAAF CLRRHAKQRE KERLAALGPE GAADTTLEYQ ELCRQHMAAK
SLFGRTEAPA APAETSRVSS VSSQFSDAPQ PSPSSHSSTP SWCEEPVQSN MDISTGHMIL
AYMEDHLRNQ DRLAKEWQAL CAYQAEPSIC SVAQSEANLK KNRNSDYVPY DHVRIKLKAE
SNPSRSDFIN ASPIIDHDPR MPAYIATQGP LSHTIADFWQ VNLVSEHIWC EDFLVRSFYL
KNVQSQETRT LTQFHFLSWP AEGIPTTTRP LLDFRRKVNK CYRGRSCPII VHCSDGAGRT
GTYILVDMVL NRMAKGVKEI DIAATLEHIR DQRPGMVQTK DQFEFALTAV AEEVNAILKA
LPQ
//
