ID A0A3N4KWK2_9PEZI Unreviewed; 502 AA.
AC A0A3N4KWK2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 28-JAN-2026, entry version 26.
DE SubName: Full=Sphingosine kinase {ECO:0000313|EMBL:RPB14920.1};
GN ORFNames=P167DRAFT_603590 {ECO:0000313|EMBL:RPB14920.1};
OS Morchella conica CCBAS932.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC Pezizales; Morchellaceae; Morchella.
OX NCBI_TaxID=1392247 {ECO:0000313|EMBL:RPB14920.1, ECO:0000313|Proteomes:UP000277580};
RN [1] {ECO:0000313|EMBL:RPB14920.1, ECO:0000313|Proteomes:UP000277580}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCBAS932 {ECO:0000313|EMBL:RPB14920.1,
RC ECO:0000313|Proteomes:UP000277580};
RX PubMed=30420746; DOI=10.1038/s41559-018-0710-4;
RA Murat C., Payen T., Noel B., Kuo A., Morin E., Chen J., Kohler A.,
RA Krizsan K., Balestrini R., Da Silva C., Montanini B., Hainaut M.,
RA Levati E., Barry K.W., Belfiori B., Cichocki N., Clum A., Dockter R.B.,
RA Fauchery L., Guy J., Iotti M., Le Tacon F., Lindquist E.A., Lipzen A.,
RA Malagnac F., Mello A., Molinier V., Miyauchi S., Poulain J., Riccioni C.,
RA Rubini A., Sitrit Y., Splivallo R., Traeger S., Wang M., Zifcakova L.,
RA Wipf D., Zambonelli A., Paolocci F., Nowrousian M., Ottonello S.,
RA Baldrian P., Spatafora J.W., Henrissat B., Nagy L.G., Aury J.M.,
RA Wincker P., Grigoriev I.V., Bonfante P., Martin F.M.;
RT "Pezizomycetes genomes reveal the molecular basis of ectomycorrhizal
RT truffle lifestyle.";
RL Nat. Ecol. Evol. 2:1956-1965(2018).
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DR EMBL; ML119115; RPB14920.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3N4KWK2; -.
DR FunCoup; A0A3N4KWK2; 597.
DR STRING; 1392247.A0A3N4KWK2; -.
DR InParanoid; A0A3N4KWK2; -.
DR OrthoDB; 3853857at2759; -.
DR Proteomes; UP000277580; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0016020; C:membrane; IEA:TreeGrafter.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0001727; F:lipid kinase activity; IEA:TreeGrafter.
DR GO; GO:0046512; P:sphingosine biosynthetic process; IEA:TreeGrafter.
DR Gene3D; 2.60.200.40; -; 1.
DR Gene3D; 3.40.50.10330; Probable inorganic polyphosphate/atp-NAD kinase, domain 1; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR055916; DUF7493.
DR InterPro; IPR050187; Lipid_Phosphate_FormReg.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR InterPro; IPR045540; YegS/DAGK_C.
DR PANTHER; PTHR12358:SF31; ACYLGLYCEROL KINASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR Pfam; PF24321; DUF7493; 1.
DR Pfam; PF19279; YegS_C; 1.
DR SMART; SM00046; DAGKc; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:RPB14920.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000277580};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 135..274
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..23
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 502 AA; 54832 MW; CFE1D850EB245297 CRC64;
MSSSPLMPAA PRSTSPSSSV VPDSEFPLGK TITLGKLLSL TVTEESLIIL DENIKKSSRS
CCSAWPTVNR KRTIALYNIL WADVGVTAIT LNFAESTSNS SVRPTSLTYP FQLTALESVE
KWVIYLLDRA YEDSLALKRF KVIINPFGGS GQAVNIFDKQ SKALLEAARC KLDIEHTTHY
KHAVDIAENL DIDLFDGIIC CSGDGVPHEV FNGFAKRNDA TRALNKIAVC QLPGGSGNAM
CWNLTGTGSA SLATVAIIKG KRRSIDLLSI TQGNNRLISF LSQSVGMIAE VDLGTEHLRW
MGDARFTVGL LQRISRQTIY PCDISIKTAI EDKDSIRDHY RTYEGDKGII KQNIDNGGQF
PGLKYGTVND PLPGDWETVH HAEMGIFYAG NMAWMSAGAN FFPASCPRDG FLDVITIPGT
LSRLSATKVL LAVEKGHHFN LDQVNYKKVV AYRITPHKRE GVAEEYVSID GERVDFAPLQ
VEVHQGLGTV LAKGDGYEAP GV
//
