ID A0A3P8UKA5_CYNSE Unreviewed; 288 AA.
AC A0A3P8UKA5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 18-JUN-2025, entry version 29.
DE RecName: Full=Tumor necrosis factor receptor type 1-associated DEATH domain protein {ECO:0000256|ARBA:ARBA00015474};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000002284.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000002284.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278; DOI=10.1038/ng.2890;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000002284.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_008308247.1; XM_008310025.2.
DR RefSeq; XP_008308248.1; XM_008310026.2.
DR RefSeq; XP_016887826.1; XM_017032337.1.
DR RefSeq; XP_024911406.1; XM_025055638.1.
DR AlphaFoldDB; A0A3P8UKA5; -.
DR FunCoup; A0A3P8UKA5; 1573.
DR STRING; 244447.ENSCSEP00000002284; -.
DR Ensembl; ENSCSET00000002324.1; ENSCSEP00000002284.1; ENSCSEG00000001534.1.
DR GeneID; 103378721; -.
DR KEGG; csem:103378721; -.
DR CTD; 8717; -.
DR GeneTree; ENSGT00390000002016; -.
DR InParanoid; A0A3P8UKA5; -.
DR OMA; QPCSRFL; -.
DR OrthoDB; 9903238at2759; -.
DR Proteomes; UP000265120; Chromosome 5.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0002947; C:tumor necrosis factor receptor superfamily complex; IEA:TreeGrafter.
DR GO; GO:0005068; F:transmembrane receptor protein tyrosine kinase adaptor activity; IEA:TreeGrafter.
DR GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:TreeGrafter.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:InterPro.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.30.70.680; TRADD, N-terminal domain; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_dom.
DR InterPro; IPR035712; TRADD.
DR InterPro; IPR009095; TRADD_N.
DR InterPro; IPR036729; TRADD_N_sf.
DR PANTHER; PTHR14913; TUMOR NECROSIS FACTOR RECEPTOR TYPE 1-ASSOCIATED DEATH DOMAIN PROTEIN; 1.
DR PANTHER; PTHR14913:SF0; TUMOR NECROSIS FACTOR RECEPTOR TYPE 1-ASSOCIATED DEATH DOMAIN PROTEIN; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF09034; TRADD_N; 1.
DR SMART; SM00005; DEATH; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF55044; TRADD, N-terminal domain; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120}.
FT DOMAIN 199..288
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
SQ SEQUENCE 288 AA; 32320 MW; E567CD05FC543622 CRC64;
MADKVVDRGP WTGCAVLFLQ SLCPNVNLLS LFKEQGGKFI IFKVIKLTLT DSAGGLRGYE
ILKVHDADPF LGVELKFVDV AACQQFLESY SSGAVSQSLS QHACRLLSLS QELKVETKLK
ASTHNLDQDL DELELCLERI HLSQPERLRD EEIDHLEQQL RRQALGPAQQ LPIIVQEEPP
LPSNCFKFQN KVFEDRMLTA ADVQSFSNAV GRQWKHVGRA LGKSCCALKG QAIDNLAYEY
EREGLYEQAY QLLSRFIQAE GRAAKLSRLI KALEDCKLTS LAENILDI
//
