ID A0A3P8W7M6_CYNSE Unreviewed; 487 AA.
AC A0A3P8W7M6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 28-JAN-2026, entry version 30.
DE RecName: Full=NAD(+) kinase {ECO:0000256|ARBA:ARBA00012120};
DE EC=2.7.1.23 {ECO:0000256|ARBA:ARBA00012120};
OS Cynoglossus semilaevis (Tongue sole).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Cynoglossidae;
OC Cynoglossinae; Cynoglossus.
OX NCBI_TaxID=244447 {ECO:0000313|Ensembl:ENSCSEP00000022517.1, ECO:0000313|Proteomes:UP000265120};
RN [1] {ECO:0000313|Ensembl:ENSCSEP00000022517.1, ECO:0000313|Proteomes:UP000265120}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24487278; DOI=10.1038/ng.2890;
RA Chen S., Zhang G., Shao C., Huang Q., Liu G., Zhang P., Song W., An N.,
RA Chalopin D., Volff J.N., Hong Y., Li Q., Sha Z., Zhou H., Xie M., Yu Q.,
RA Liu Y., Xiang H., Wang N., Wu K., Yang C., Zhou Q., Liao X., Yang L.,
RA Hu Q., Zhang J., Meng L., Jin L., Tian Y., Lian J., Yang J., Miao G.,
RA Liu S., Liang Z., Yan F., Li Y., Sun B., Zhang H., Zhang J., Zhu Y., Du M.,
RA Zhao Y., Schartl M., Tang Q., Wang J.;
RT "Whole-genome sequence of a flatfish provides insights into ZW sex
RT chromosome evolution and adaptation to a benthic lifestyle.";
RL Nat. Genet. 46:253-260(2014).
RN [2] {ECO:0000313|Ensembl:ENSCSEP00000022517.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSCSEP00000022517.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NAD kinase family.
CC {ECO:0000256|ARBA:ARBA00010995}.
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DR RefSeq; XP_008332762.1; XM_008334540.3.
DR AlphaFoldDB; A0A3P8W7M6; -.
DR STRING; 244447.ENSCSEP00000022517; -.
DR Ensembl; ENSCSET00000022806.1; ENSCSEP00000022517.1; ENSCSEG00000014348.1.
DR GeneID; 103396453; -.
DR KEGG; csem:103396453; -.
DR CTD; 562771; -.
DR GeneTree; ENSGT00940000165431; -.
DR InParanoid; A0A3P8W7M6; -.
DR OrthoDB; 24581at2759; -.
DR Proteomes; UP000265120; Chromosome 20.
DR GO; GO:0003951; F:NAD+ kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0019674; P:NAD+ metabolic process; IEA:InterPro.
DR GO; GO:0006741; P:NADP+ biosynthetic process; IEA:InterPro.
DR FunFam; 2.60.200.30:FF:000003; NAD kinase b; 1.
DR Gene3D; 3.40.50.10330; Probable inorganic polyphosphate/atp-NAD kinase, domain 1; 1.
DR Gene3D; 2.60.200.30; Probable inorganic polyphosphate/atp-NAD kinase, domain 2; 1.
DR HAMAP; MF_00361; NAD_kinase; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR017437; ATP-NAD_kinase_PpnK-typ_C.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR InterPro; IPR002504; NADK.
DR PANTHER; PTHR20275; NAD KINASE; 1.
DR PANTHER; PTHR20275:SF29; NAD(+) KINASE; 1.
DR Pfam; PF01513; NAD_kinase; 1.
DR Pfam; PF20143; NAD_kinase_C; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW NAD {ECO:0000256|ARBA:ARBA00023027}; NADP {ECO:0000256|ARBA:ARBA00022857};
KW Reference proteome {ECO:0000313|Proteomes:UP000265120};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT REGION 1..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..11
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..53
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 487 AA; 53945 MW; D1D95AC7CFB12D22 CRC64;
MENSETSSTC GGLTVPDGVM ARPSGPPGQL AESARSSKHR EHPSKSPRRR REGKRSQRRG
DGHEQLLWET ERRRLPGQHE HLEPSGSASD TLESSPKRRA HFLHGPYPAT HFGPKACILP
NPTSVMHIQD PASQRLTWNK PPVNVLVIRK IRDESLVEPF KELCRFLVEE KQMMVYVERR
VADDALLSKD EAFGSIRNQL CTFREGFDDI SDCIDLIICL GGDGTLLYAS SLFQGSVPPV
MAFHLGSLGF LTPFKFESYK TEVAKVFEGN AAITLRSRLK VKVVKDMLQR TGREPAQQPQ
EHNGILTHGH SEAGKVTLQL QVLNEVVIDR GPSSYLSNVD LYLNGRLITS VQGDGVIVST
PTGSTAYAAA AGASMIHPNV PAIMVTPICP HSLSFRPIVV PAGVELMITL SPDARNTAWV
SFDGRKRQEI QHGDCIKITT SCYPVPSICC HDLVYDWFES LAQCLHWNVR KRQARLAEIS
DSSDTEN
//
