ID A0A3P8Z060_ESOLU Unreviewed; 548 AA.
AC A0A3P8Z060;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2025, sequence version 2.
DT 28-JAN-2026, entry version 33.
DE RecName: Full=Suppressor of cytokine signaling 9 {ECO:0008006|Google:ProtNLM};
OS Esox lucius (Northern pike).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes;
OC Esocidae; Esox.
OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000021823.2, ECO:0000313|Proteomes:UP000265140};
RN [1] {ECO:0000313|Proteomes:UP000265140}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25069045;
RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R.,
RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.;
RT "The genome and linkage map of the northern pike (Esox lucius): conserved
RT synteny revealed between the salmonid sister group and the Neoteleostei.";
RL PLoS ONE 9:e102089-e102089(2014).
RN [2] {ECO:0000313|Ensembl:ENSELUP00000021823.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Myers G., Karagic N., Meyer A., Pippel M., Reichard M., Winkler S.,
RA Tracey A., Sims Y., Howe K., Rhie A., Formenti G., Durbin R., Fedrigo O.,
RA Jarvis E.D.;
RT "Esox lucius (northern pike) genome, fEsoLuc1, primary haplotype.";
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSELUP00000021823.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [4] {ECO:0000313|Ensembl:ENSELUP00000021823.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_010890497.2; XM_010892195.4.
DR AlphaFoldDB; A0A3P8Z060; -.
DR STRING; 8010.ENSELUP00000021823; -.
DR Ensembl; ENSELUT00000032588.3; ENSELUP00000021823.2; ENSELUG00000020836.3.
DR GeneID; 105023196; -.
DR KEGG; els:105023196; -.
DR CTD; 100003691; -.
DR GeneTree; ENSGT00940000164285; -.
DR InParanoid; A0A3P8Z060; -.
DR OMA; SYRIHTQ; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000265140; Chromosome 1.
DR Bgee; ENSELUG00000020836; Expressed in ovary and 15 other cell types or tissues.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF18; SUPPRESSOR OF CYTOKINE SIGNALING 9 ISOFORM X1; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000265140};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 396..491
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 486..535
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 548 AA; 61018 MW; 3DFD106806A51226 CRC64;
MSQPKESGDR GKERERGARP KVRQSRSEER RDAGGGAKGG RGKKKGQMSY EQAAERPVSD
GFEYGDLLSG LEPRDRSSSS PLKSRRWQGL EGATSLSQDR GTARLAQGTA ETSASEADSK
GAGGSRTLRQ KIQDAMGQCF PIKIHTPSPS LSSSTQQVFV PQAASSAASS RRKIHLSELM
LDDCPFAAGT ELAQKWYLIK QHTAPISTPP LLDILVVSTS ASASNMAAVV EDVDDRLRER
RRISIEQGVE PPPNAEIHTF EVTAQINPLY KLGPKLAHGM NELAGDERAT IQQQQQLLLQ
RQQQHQLLLQ SCLDTLDEVV AVASSSSASA LVPVCEATAV SDPVAYPEDT ASIQPSRAVV
PQNEHPPTQD GYRIHTQIDY IHCLVPDLLQ ITNLPCYWGV MDRYEAETLL EGKPEGTFLL
RDSAQEDYLF SVSFRRYGRS LHARIEQWNH NFSFDVHDPS VFHAPTVTGL LEHYKDPNSC
MFFEPLLSNP IHRTQPFSLQ HVCRAVISSC TTYDGVNVLP IPNTLKKHLK EYHYKQRVRV
RRMDTWWE
//
