ID A0A3P9BQ66_9CICH Unreviewed; 823 AA.
AC A0A3P9BQ66;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 18-JUN-2025, entry version 32.
DE SubName: Full=MALT paracaspase 2 {ECO:0000313|Ensembl:ENSMZEP00005012080.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005012080.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005012080.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005012080.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_004555016.1; XM_004554959.1.
DR RefSeq; XP_004555017.1; XM_004554960.2.
DR RefSeq; XP_004555018.1; XM_004554961.2.
DR AlphaFoldDB; A0A3P9BQ66; -.
DR STRING; 106582.ENSMZEP00005012080; -.
DR Ensembl; ENSMZET00005012507.1; ENSMZEP00005012080.1; ENSMZEG00005009058.1.
DR GeneID; 101479549; -.
DR KEGG; mze:101479549; -.
DR CTD; 259196; -.
DR GeneTree; ENSGT00390000018044; -.
DR OrthoDB; 7079at1489911; -.
DR Proteomes; UP000265160; LG23.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00096; Ig; 1.
DR FunFam; 3.40.50.1460:FF:000004; Mucosa-associated lymphoid tissue lymphoma translocation protein 1; 1.
DR Gene3D; 2.60.40.3360; -; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR052039; Caspase-related_regulators.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR041077; MALT1_Ig.
DR InterPro; IPR033540; MALT1_IG-like_dom_sf.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR001309; Pept_C14_p20.
DR PANTHER; PTHR22576; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1/PARACASPASE; 1.
DR PANTHER; PTHR22576:SF27; PARACASPASE 2; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF18703; MALT1_Ig; 1.
DR Pfam; PF00656; Peptidase_C14; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50208; CASPASE_P20; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00022692};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}.
FT DOMAIN 106..182
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 201..287
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 334..461
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT REGION 752..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..777
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 823 AA; 91415 MW; CF2D892A8B7D3BE4 CRC64;
MEEWKRSIGT LSDEILIKLA KMLDNSTCGW RQLANAVSEQ PKFRCSEREL TSCSLQVLTA
AGSPARTMLT LLAERSCSLD FLLHSLRKME HQEAVQFLTT AVAEQIQITV QPQSQEAAPG
SNVVLTCRAS GPPGLGYQWF KGKQEILGES GNSSELVLCP LSPTHQGHYI CRISHGEKFV
FSKWAQVRLI ISAGCSSSLF PGSVSGLHII QRPQSQAASE GDTLVLECTA EGNPPAQYEW
YHNKVPMPQQ KTSSLRIPCV TTAHRGEYTC KVFNLYHEVW SSTATVTIGP SSVTDASWVE
VDRGLESQEV HKTYLPGTHP LASSPPSAKD VYATDKVALL IGNMNYIYHT QLCAPISDVH
ELTNLLRQLD FKVVSLLDLN WQEMHSAVTE FLLLLDKGVY GLLYFAGHGY ENYGNSFMVP
IDAPVSYTSE HCLCVQNILT KMQEKKTGLN VFLLDMCRKR NPHDDVIVQP GLLKVTANIV
FGYATCVDAE AYEVKREDVS NGIFINFLKQ RVCEDEKVTV MLDRVAEDMG RCVITRGRQA
LELRSNLSER RSLTDRIQVS QCSASSSARN LQWAIAHVLP ESRYLQFDCG VKVQLGFAAE
FSNVMVIYTR ILDKPDEIVS CSAQLTDFPE DVDIDLKKSN QESLLEAGCL SLIKEELPSP
ETHSLYTHIR SLQRLKRELT FTICLHYTYS NMDEEVQERQ QVTVGKPLVS KLNLHEPRAA
HVSSASSSFS LDSFNVPGCS SFGEDLSLTG TASNTRSHHA QSASVSFTGG SPTSPRSANV
PEETDSPEIL DNPRPLVASK SLPHSKVNDS NYKFSDMYNF HSY
//
