ID A0A3P9CWN1_9CICH Unreviewed; 1108 AA.
AC A0A3P9CWN1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 18-JUN-2025, entry version 32.
DE SubName: Full=Ring finger protein 31 {ECO:0000313|Ensembl:ENSMZEP00005026226.1};
GN Name=RNF31 {ECO:0000313|Ensembl:ENSMZEP00005026226.1};
OS Maylandia zebra (zebra mbuna).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Maylandia; Maylandia zebra complex.
OX NCBI_TaxID=106582 {ECO:0000313|Ensembl:ENSMZEP00005026226.1, ECO:0000313|Proteomes:UP000265160};
RN [1] {ECO:0000313|Ensembl:ENSMZEP00005026226.1, ECO:0000313|Proteomes:UP000265160}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25186727; DOI=10.1038/nature13726;
RA Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J., Johnson J.,
RA Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J., Amemiya C.,
RA Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A., Bloomquist R.,
RA Carleton K.L., Conte M.A., D'Cotta H., Eshel O., Gaffney L., Galibert F.,
RA Gante H.F., Gnerre S., Greuter L., Guyon R., Haddad N.S., Haerty W.,
RA Harris R.M., Hofmann H.A., Hourlier T., Hulata G., Jaffe D.B., Lara M.,
RA Lee A.P., MacCallum I., Mwaiko S., Nikaido M., Nishihara H.,
RA Ozouf-Costaz C., Penman D.J., Przybylski D., Rakotomanga M., Renn S.C.P.,
RA Ribeiro F.J., Ron M., Salzburger W., Sanchez-Pulido L., Santos M.E.,
RA Searle S., Sharpe T., Swofford R., Tan F.J., Williams L., Young S., Yin S.,
RA Okada N., Kocher T.D., Miska E.A., Lander E.S., Venkatesh B., Fernald R.D.,
RA Meyer A., Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA Di Palma F.;
RT "The genomic substrate for adaptive radiation in African cichlid fish.";
RL Nature 513:375-381(2014).
RN [2] {ECO:0000313|Ensembl:ENSMZEP00005026226.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RBR family. {ECO:0000256|ARBA:ARBA00008278}.
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DR AlphaFoldDB; A0A3P9CWN1; -.
DR STRING; 106582.ENSMZEP00005026226; -.
DR Ensembl; ENSMZET00005027071.1; ENSMZEP00005026226.1; ENSMZEG00005019563.1.
DR GeneTree; ENSGT00530000064112; -.
DR Proteomes; UP000265160; LG9.
DR GO; GO:0071797; C:LUBAC complex; IEA:InterPro.
DR GO; GO:0036435; F:K48-linked polyubiquitin modification-dependent protein binding; IEA:TreeGrafter.
DR GO; GO:0070530; F:K63-linked polyubiquitin modification-dependent protein binding; IEA:TreeGrafter.
DR GO; GO:1990450; F:linear polyubiquitin binding; IEA:TreeGrafter.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:TreeGrafter.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0097039; P:protein linear polyubiquitination; IEA:TreeGrafter.
DR CDD; cd20337; BRcat_RBR_HOIP; 1.
DR CDD; cd16631; mRING-HC-C4C4_RBR_HOIP; 1.
DR CDD; cd20351; Rcat_RBR_HOIP; 1.
DR Gene3D; 1.20.58.2190; -; 1.
DR Gene3D; 6.10.140.1100; -; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR047540; BRcat_RBR_RNF31-like.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR036339; PUB-like_dom_sf.
DR InterPro; IPR018997; PUB_domain.
DR InterPro; IPR047542; Rcat_RBR_RNF31-like.
DR InterPro; IPR026254; RNF31-like.
DR InterPro; IPR032065; RNF31-UBA.
DR InterPro; IPR041031; RNF31_C.
DR InterPro; IPR047541; RNF31_RBR_mRING-HC-like.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR16004:SF5; E3 UBIQUITIN-PROTEIN LIGASE RNF31; 1.
DR PANTHER; PTHR16004; RING FINGER PROTEIN 31-RELATED; 1.
DR Pfam; PF18091; E3_UbLigase_RBR; 1.
DR Pfam; PF01485; IBR; 1.
DR Pfam; PF22191; IBR_1; 1.
DR Pfam; PF09409; PUB; 1.
DR Pfam; PF16678; UBA_HOIP; 1.
DR Pfam; PF25163; UBA_RNF31; 1.
DR SMART; SM00647; IBR; 2.
DR SMART; SM00547; ZnF_RBZ; 3.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF143503; PUG domain-like; 1.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 2.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS50030; UBA; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 3.
DR PROSITE; PS50199; ZF_RANBP2_2; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00322}.
FT DOMAIN 285..331
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 340..369
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 385..415
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 618..660
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 740..971
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 744..792
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..218
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..228
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..582
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1108 AA; 124342 MW; 31DE4DF3517B9AAE CRC64;
MSSSPASVQM DEARRRAQSL LSSSGSAQEV KADVQTMATI ELPLSEKYRH VSAEVMLKEN
SAGRNKQEVL ESLNRFIKAL SILEKYGCNL TSPTRPRYWR SVKHNNPVFR TTVDAIKGGR
RVLYLYGYTN QQVDGLSFPD EVEDPDTEKV AAVTLEVMTL RTEVDMIVKG THPHLEHFKE
IIPFVIPKAQ MVTDSVAKLP VEEKKQQQQQ QQGDKPLILP LPPKPALVPK PSTGSAAVSG
CSLCGGDASL FCSACDNPHF CDACDDLFHR HPNRASHKRD KLQQTKQNTC TICGISAVHA
RCATCLQRLC LKCDKLYHSH PDRKGHNRTI TTPAKTSSPS LSPWECSHCT TVNEMRAVLC
TTCERPRLAT AVSTVLESTM SLPASPNAEW QCKSCTVMNQ GSSILCEVCE RPRLATRPPV
SSDMSILRSL SDAKQWTCQF CTFANTKAST VCEMCNMSPK DSGGLSLPQS LQQTPCGPKD
RPQPKPRVNL ELKRQKTMKE DGLALVRHIR EAEQRGISPE EVYAALGACG GSNVNPCDWL
TSELPHLLDE ICAMAASVQL NYKMGRVGTQ PVLERDGGES EKSGPTSIGD SMKLSRAEAK
LAWLKTGGET DKAVRELLRD RKEKMKELHS LGFQDVAQCE EALRQSGGEM QGALSLLQRP
LLEAFHQRIW TAQPEPPIDP AHPDKQRTCR RLLALYDLPS WGRCELVLSL LQEPGVSYSL
EDVVQAVKES HDRDFIRRLL NNECPICLSI FPRSKMQSLT SCQCSVCLEC FKAHFTIAVR
DKHIRDMVCP SCCEPDINDP EKLDSYFSTL DIQLRDCLEP EVYDLFHKKL TEHALMKDPK
FMWCCHCTSG FINEGDQLKV TCLSCHKSFC AQCKKPWEPQ HQDVSCEQFQ LWKRENDPEY
QRQGLAGYLR DNGITCPHCR FQYALTKGGC MHFSCSQCRY QFCSGCNNPY HKTKCKPDCS
LNCLHAHHPR DCLFYLRDWE PPRLQAFLQR SGVEFNTDPS NGAQTDECGV MEQKDEGGQQ
VDSPCGIKTQ PGQAGLCDKH YREYLVSLIN AHSLDPALIY DLNEVIRACE RYQVDVQRGE
GEEDNAYQAR LLKKLMEVPL GEKVPRNK
//
