ID   A0A3P9P1T2_POERE        Unreviewed;       418 AA.
AC   A0A3P9P1T2;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   28-JAN-2026, entry version 30.
DE   SubName: Full=Suppressor of cytokine signaling 9 {ECO:0000313|Ensembl:ENSPREP00000015653.1};
OS   Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000015653.1, ECO:0000313|Proteomes:UP000242638};
RN   [1] {ECO:0000313|Proteomes:UP000242638}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA   Kuenstner A., Dreyer C.;
RT   "The genomic landscape of the Guanapo guppy.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPREP00000015653.1}
RP   IDENTIFICATION.
RC   STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000015653.1};
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSPREP00000015653.1}
RP   IDENTIFICATION.
RC   STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000015653.1};
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
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DR   STRING; 8081.ENSPREP00000015653; -.
DR   Ensembl; ENSPRET00000015817.1; ENSPREP00000015653.1; ENSPREG00000010568.1.
DR   GeneTree; ENSGT00940000164285; -.
DR   OMA; SYRIHTQ; -.
DR   Proteomes; UP000242638; Unassembled WGS sequence.
DR   Bgee; ENSPREG00000010568; Expressed in caudal fin and 1 other cell type or tissue.
DR   GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR   GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR022252; SOCS4/SOCS5_dom.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF18; SUPPRESSOR OF CYTOKINE SIGNALING 9 ISOFORM X1; 1.
DR   Pfam; PF12610; SOCS; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999}.
FT   DOMAIN          124..154
FT                   /note="SOCS4/SOCS5"
FT                   /evidence="ECO:0000259|Pfam:PF12610"
FT   REGION          1..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..18
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..35
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   418 AA;  45047 MW;  9857050612AE3AFF CRC64;
     MSLPNESGNR GKERERGARP KVRQSRSEER RDSAGGRKGG KGKNKGLSTH DTATERPVSD
     GFEYGELLND LEARSQTSSS TSPLKETWKW QGLDVAGSTP GQGVTAKQGQ GTVCSAAELP
     PLSEVEGRGS SSSRTLRQKI QDAMGQCFPI KTHSAAAAPP PPPQAFXSSA ACASSSRRKI
     HLSELMLDDC PFPVGSELAQ KWYLIKQHTA PITQPPLLDP AAVVCSAPTS ATAAVEDVDD
     KLRERRRISI EQGVEPPPNA EIHTFEVTAQ INPLYKHGPK LAHGMNELAG TEGASAHQQQ
     QMLLQRQQQH QLLLQSCLDT LDEVAASASA SLHASDAASD PPVDTEAAAA AVSNSSSRAA
     ALPRXEHQTP HEGYRFHTQI DYIHCLVPDL LQITNLPCYW GVMDRYEAET LLEGKPEG
//