ID A0A3Q0CHD4_MESAU Unreviewed; 652 AA.
AC A0A3Q0CHD4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 18-JUN-2025, entry version 28.
DE RecName: Full=Sodium/nucleoside cotransporter {ECO:0000256|RuleBase:RU362018};
GN Name=Slc28a2 {ECO:0000313|RefSeq:XP_021081950.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021081950.1};
RN [1] {ECO:0000313|RefSeq:XP_021081950.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the concentrative nucleoside transporter (CNT)
CC (TC 2.A.41) family. {ECO:0000256|ARBA:ARBA00009033,
CC ECO:0000256|RuleBase:RU362018}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_021081950.1; XM_021226291.1.
DR RefSeq; XP_040602123.1; XM_040746189.1.
DR RefSeq; XP_040602124.1; XM_040746190.1.
DR RefSeq; XP_040602125.1; XM_040746191.1.
DR AlphaFoldDB; A0A3Q0CHD4; -.
DR STRING; 10036.ENSMAUP00000003950; -.
DR GeneID; 101839720; -.
DR OrthoDB; 6075923at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005415; F:nucleoside:sodium symporter activity; IEA:TreeGrafter.
DR GO; GO:0015211; F:purine nucleoside transmembrane transporter activity; IEA:TreeGrafter.
DR GO; GO:0001895; P:retina homeostasis; IEA:TreeGrafter.
DR InterPro; IPR008276; C_nuclsd_transpt.
DR InterPro; IPR018270; C_nuclsd_transpt_met_bac.
DR InterPro; IPR011657; CNT_C_dom.
DR InterPro; IPR002668; CNT_N_dom.
DR InterPro; IPR011642; Gate_dom.
DR NCBIfam; TIGR00804; nupC; 1.
DR PANTHER; PTHR10590; SODIUM/NUCLEOSIDE COTRANSPORTER; 1.
DR PANTHER; PTHR10590:SF11; SODIUM_NUCLEOSIDE COTRANSPORTER 2; 1.
DR Pfam; PF07670; Gate; 1.
DR Pfam; PF07662; Nucleos_tra2_C; 1.
DR Pfam; PF01773; Nucleos_tra2_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362018};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362018};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362018}; Transport {ECO:0000256|RuleBase:RU362018}.
FT TRANSMEM 74..95
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 101..120
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 140..159
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 165..184
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 251..272
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 284..307
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 327..349
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 356..375
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 410..431
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 521..545
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT TRANSMEM 557..581
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362018"
FT DOMAIN 172..244
FT /note="Concentrative nucleoside transporter N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01773"
FT DOMAIN 253..350
FT /note="Nucleoside transporter/FeoB GTPase Gate"
FT /evidence="ECO:0000259|Pfam:PF07670"
FT DOMAIN 356..577
FT /note="Concentrative nucleoside transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07662"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 652 AA; 72149 MW; 4CE217C2EF6153E8 CRC64;
MEKEAGRGSA SQATMKNGIE NPGLELMERG DPERSKKAEV TQEHSPKDGW RRSLHPFIKA
RSFFKRHAVL FKKILLGLLC AAYAAYFLAA CILNFQRALA LFVITCLVIF FLACHFLEKF
FGKKLISCLK PFKNPRLRRW VKWVFAGASV VGLILWLALD TAQRPEQLIS FAGICMFILI
LFVFSKHHSA VCWRTVFWGL GLQFVFGILV IRTEPGFNAF QWLGDQIQIF LAYTVEGSSF
VFGDTLVQSV FAFQSLPIII FFGCVMSILY YLGLVQWVIQ KIAWFLQITM GTTAAETLAV
AGNIFVGMTE APLLIRPYLA DMTLSEIHAV MTGGFATIAG TVLGAFISFG IDASSLISAS
VMAAPCALAL SKLVYPEVEE SKFKSKEGVK LPRRDERNIL EAASNGATDA IALVANVAAN
LIAFLAVLAF VNSTLSWLGE MVDIHGLSFQ VICSYVLRPM VFMMGVEWAD CPLVAEIVGV
KFFINEFVAY EQLSQYKNKR LSGVEEWING EKQWISVKAE IIATFSLCGF ANLSSIGITL
GGLTSMMPQR KSDLCKIVVR ALFTGACVSF ISACMAGILY VPRGAEADCV SFLNTSFTNR
TYDTYVCCRE LFHNTWLNGT NMPSFSGSWE DKEFSALSLA TCCDLYNSTV CV
//
