ID A0A3Q0DHD9_MESAU Unreviewed; 1263 AA.
AC A0A3Q0DHD9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 18-JUN-2025, entry version 27.
DE SubName: Full=Calmodulin-regulated spectrin-associated protein 3 isoform X4 {ECO:0000313|RefSeq:XP_021091739.1};
GN Name=Camsap3 {ECO:0000313|RefSeq:XP_021091739.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021091739.1};
RN [1] {ECO:0000313|RefSeq:XP_021091739.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- DOMAIN: The CKK domain binds microtubules. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
CC -!- SIMILARITY: Belongs to the CAMSAP1 family. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_021091739.1; XM_021236080.1.
DR AlphaFoldDB; A0A3Q0DHD9; -.
DR Ensembl; ENSMAUT00000013088; ENSMAUP00000009242; ENSMAUG00000010380.
DR GeneID; 101831803; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0036449; C:microtubule minus-end; IEA:TreeGrafter.
DR GO; GO:0005516; F:calmodulin binding; IEA:InterPro.
DR GO; GO:0051011; F:microtubule minus-end binding; IEA:TreeGrafter.
DR GO; GO:0030507; F:spectrin binding; IEA:InterPro.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:TreeGrafter.
DR GO; GO:0007026; P:negative regulation of microtubule depolymerization; IEA:TreeGrafter.
DR GO; GO:0031175; P:neuron projection development; IEA:InterPro.
DR FunFam; 3.10.20.360:FF:000001; Calmodulin-regulated spectrin-associated protein 3 isoform 2; 1.
DR Gene3D; 3.10.20.360; CKK domain; 1.
DR InterPro; IPR032940; CAMSAP.
DR InterPro; IPR022613; CAMSAP-like_CH_dom.
DR InterPro; IPR031372; CAMSAP_CC1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR038209; CKK_dom_sf.
DR InterPro; IPR014797; CKK_domain.
DR InterPro; IPR011033; PRC_barrel-like_sf.
DR PANTHER; PTHR21595:SF2; CALMODULIN-REGULATED SPECTRIN-ASSOCIATED PROTEIN 3; 1.
DR PANTHER; PTHR21595; PATRONIN; 1.
DR Pfam; PF17095; CAMSAP_CC1; 1.
DR Pfam; PF11971; CAMSAP_CH; 1.
DR Pfam; PF08683; CAMSAP_CKK; 1.
DR SMART; SM01051; CAMSAP_CKK; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF50346; PRC-barrel domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS51508; CKK; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|PROSITE-
KW ProRule:PRU00841}; Reference proteome {ECO:0000313|Proteomes:UP000189706}.
FT DOMAIN 219..328
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1123..1257
FT /note="CKK"
FT /evidence="ECO:0000259|PROSITE:PS51508"
FT REGION 183..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 445..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 497..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 729..995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1018..1039
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1075..1125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..367
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..389
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..399
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..597
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..699
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..756
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..785
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 829..842
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 904..951
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 952..982
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1263 AA; 136287 MW; E7E422A706D6047C CRC64;
MVEAAPAGSG PLRRTFLVPE IKSLDQYDFS RAKAAASLAW VLRAAFGGAE HVPPELWEPF
YTDQYAQEHV KPPVTRLLLS AELYCRAWRQ ALPQLEPPPN PSALLALLAR RGTVPSLPEH
PVREADLRHQ PILMGAHLAV IDALMVAFSF EWTKTLPGPL ALSSLEHKLL FWVDTTVRRL
QEKTEQEAAQ RASPAAPLDG AAPAQPSHAI AFCLKESGNK PPMIRYRKDR AIARRAPCFP
NVTTLQDLAS GAALAATIHC YCPQLLRLEE VCLKDPMSVA DSLYNLQLVQ DFCASHLPRG
CPLSLEDLLY VPPPLKVNLV VLLAEMYMCF EVLKPDFVQA KDLPDGHASS PRGTETLSSQ
NNSGSSSPVF NFRHPLLSPG GPQSPLRGST GSLKSSPSMS HMEALGKAWN RQLSRPLSQA
VSFSTPFGLD SDVDVVMGDP VLLRSVSSDS LGPPRPVSSS SRNPVQATPE SGDLPTIEEA
LQIIHSAEPR LLPDGAADGS FYLHSPEGLS KPPLASPYPP EGASKPPSDG LNKAPIYISH
PETPVKPSPC PAGEVLKPLP PSEGSPKAVA SSPAANNSEV KMTSFAERKK QLVKAEAESG
MGSPTSTPAA PEALSSEMSE LGARLEEKRR AIEAQKRRIE AIFAKHRQRL GKSAFLQVQP
REAAGEAEEE AELGSVPGGE RPAGEGQGEP SSRPKSVTFS PDLGPVPPEG LGDYNRAVSK
LSAALSSLQR DMQRLTDQQQ RLLAPPEAPG PAPPPAAWVI PGPTTGPKAA SPSPARRAPA
ARRSPGPGPN PTPRSPKHTR PAELKLAPLT RVLTPPHDVD SLPHLRKFSP SQVPVQTRSS
ILLSEGTPPE EPTTKPALIE IPLASLGEPT ADEEGDGSPA GAEDSLEEEA SSEGEPRSGL
GFFYKDEDKP EDEMAQKRAS LLERQQRRAE EARRRKQWQE AEKEQKREEA AARLAQEEVP
ATPVASTAPV ATLAPATRAA APAEEEVGPR RGDFTRLEYE RRAQLKLMDD LDKVLRPRAC
GPGRGGRRAT RPRSGCCDDS ALARSPARGL LGSRLSKVYS QSTLSLSTVA NEASNNLGVK
RPTSRAPSPS GLMSPSRLPG SRERDWENGS NASSPASVPE YTGPRLYKEP SAKSNKFIIH
NALSHCCLAG KVNEPQKNRI LEEIEKSKAN HFLILFRDSS CQFRALYTLS GETEELSRLA
GYGPRTVTPA MVEGIYKYNS DRKRFTQIPA KTMSMSVDAF TIQGHLWQSK KPTTPKKGGG
TPK
//
