ID A0A3Q0DI82_CARSF Unreviewed; 513 AA.
AC A0A3Q0DI82;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 28-JAN-2026, entry version 30.
DE SubName: Full=LOW QUALITY PROTEIN: suppressor of cytokine signaling 5-like {ECO:0000313|RefSeq:XP_021564254.1};
GN Name=LOC103251507 {ECO:0000313|RefSeq:XP_021564254.1};
OS Carlito syrichta (Philippine tarsier) (Tarsius syrichta).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Tarsiiformes; Tarsiidae;
OC Carlito.
OX NCBI_TaxID=1868482 {ECO:0000313|Proteomes:UP000189704, ECO:0000313|RefSeq:XP_021564254.1};
RN [1] {ECO:0000313|RefSeq:XP_021564254.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (AUG-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_021564254.1; XM_021708579.1.
DR GeneID; 103251507; -.
DR KEGG; csyr:103251507; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000189704; Unplaced.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.70.960; SEA domain; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF01390; SEA; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SUPFAM; SSF82671; SEA domain; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50024; SEA; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000189704};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 4..144
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 447..490
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 89..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|RefSeq:XP_021564254.1"
SQ SEQUENCE 513 AA; 58436 MW; 9F8E1CFDE2DD14F4 CRC64;
WGHHLKMLTL NFTISNLHYS PDMGTSSATF NSTERALQRL LGPLFQRSSL GPFFLGCRLT
SLSQIVEISI EKDNDSCAAP EMTLARRGSY SRHAPWGGKK KHSCSTKTQS SLDTEKKFGR
TQSELQRQER RYGVRSVRDT DGISGRTMGS RSLCQRLQET VGLCFPMRTY SKQSKPLFSN
KRKIRLSELM LEKCPFPAGS DLAPKWHLIK QHAAPVSPHS IFFDMFDPSL ISTEDGEDRL
RERRWLSIEE GVDSPPNAQI HTFEATAQVN PLYKLGPKLA PGMSEVSGDG SAIPQASCDS
EEDTTTLCLQ SRRQKQRQVS GDSHAHMSRQ GAWKVQMQID YIHCLAPDLL QIIGNPCYWG
VMDHYEAEAL LEGKPESTFL LRDSAQEDYL FSVNFHRYNR PLHAQIEQWN HNFSSDAHDP
CVFHSSTVTG LLEHYKEPSS CMFFETLLTI SLNRTFPFSL HYICHAVICR CTTYDGIDGL
PLLSMLQDFF FLKYHCKQKV RVRWLEXEPI KAK
//
