ID A0A3Q0E4Q0_CARSF Unreviewed; 4632 AA.
AC A0A3Q0E4Q0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 18-JUN-2025, entry version 30.
DE RecName: Full=Cytoplasmic dynein 1 heavy chain 1 {ECO:0000256|ARBA:ARBA00070221};
DE AltName: Full=Cytoplasmic dynein heavy chain 1 {ECO:0000256|ARBA:ARBA00079872};
DE AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
GN Name=DYNC1H1 {ECO:0000313|RefSeq:XP_021571229.1};
OS Carlito syrichta (Philippine tarsier) (Tarsius syrichta).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Tarsiiformes; Tarsiidae;
OC Carlito.
OX NCBI_TaxID=1868482 {ECO:0000313|Proteomes:UP000189704, ECO:0000313|RefSeq:XP_021571229.1};
RN [1] {ECO:0000313|RefSeq:XP_021571229.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- FUNCTION: Cytoplasmic dynein 1 acts as a motor for the intracellular
CC retrograde motility of vesicles and organelles along microtubules.
CC Dynein has ATPase activity; the force-producing power stroke is thought
CC to occur on release of ADP. Plays a role in mitotic spindle assembly
CC and metaphase plate congression. {ECO:0000256|ARBA:ARBA00053880}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR RefSeq; XP_021571229.1; XM_021715554.1.
DR STRING; 1868482.ENSTSYP00000010124; -.
DR GeneID; 103266450; -.
DR KEGG; csyr:103266450; -.
DR OrthoDB; 14187at2759; -.
DR Proteomes; UP000189704; Unplaced.
DR GO; GO:0005858; C:axonemal dynein complex; IEA:TreeGrafter.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR FunFam; 1.20.920.20:FF:000002; Cytoplasmic dynein 1 heavy chain; 1.
DR FunFam; 3.40.50.300:FF:000122; Cytoplasmic dynein 1 heavy chain; 1.
DR FunFam; 1.20.920.60:FF:000001; Cytoplasmic dynein 1 heavy chain 1; 1.
DR FunFam; 1.10.8.1220:FF:000002; cytoplasmic dynein 1 heavy chain 1-like; 1.
DR FunFam; 1.10.287.2620:FF:000001; Cytoplasmic dynein heavy chain 1; 1.
DR FunFam; 1.10.472.130:FF:000002; Cytoplasmic dynein heavy chain 1; 1.
DR FunFam; 1.10.8.710:FF:000005; Cytoplasmic dynein heavy chain 1; 1.
DR FunFam; 1.20.140.100:FF:000002; Cytoplasmic dynein heavy chain 1; 1.
DR FunFam; 1.20.58.1120:FF:000003; Cytoplasmic dynein heavy chain 1; 1.
DR FunFam; 1.20.920.30:FF:000001; Cytoplasmic dynein heavy chain 1; 1.
DR FunFam; 3.20.180.20:FF:000002; Cytoplasmic dynein heavy chain 1; 1.
DR FunFam; 3.40.50.300:FF:000071; Cytoplasmic dynein heavy chain 1; 1.
DR FunFam; 3.40.50.300:FF:000517; Cytoplasmic dynein heavy chain 1; 1.
DR FunFam; 1.10.8.720:FF:000003; Cytoplasmic dynein heavy chain 2; 1.
DR FunFam; 1.20.1270.280:FF:000004; Cytoplasmic dynein heavy chain 2; 1.
DR FunFam; 3.10.490.20:FF:000004; Cytoplasmic dynein heavy chain 2; 1.
DR FunFam; 3.40.50.300:FF:000373; Cytoplasmic dynein heavy chain 2; 1.
DR FunFam; 3.40.50.300:FF:001956; Dynein cytoplasmic 1 heavy chain 1; 1.
DR FunFam; 3.40.50.300:FF:002655; Dynein cytoplasmic 1 heavy chain 1; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 2.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 1.20.920.60; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC.
DR InterPro; IPR054354; DYNC2H1-like_lid.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF13; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF22597; DYN_lid; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000189704};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 1887..2031
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2202..2353
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2573..2723
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2915..3081
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 2376..2396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1159..1186
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3191..3239
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3388..3485
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4632 AA; 531342 MW; 3D6588AD6382A53A CRC64;
MRSWYQNYRH LSGQATQLLP CTAPDAEVHR MTVPVLGSCC HVGLPFRAHS ILGGNDFVIR
NRLPSQIGFT YQDVGDEGEE EKEFISYNIN IDIHYGVKSN SLAFIKRTPV IDADKPVSSQ
LRVLTLSEDS PYETLHSFIS NAVAPFFKSY IRESGKADRD GDKMAPSVEK KIAELEMGLL
HLQQNIEIPE ISLPIHPIIT NVAKQCYERG EKPKVTDFGD KVEDPTFLNQ LQSGVNRWIR
EIQKVTKLDR DPASGTALQE ISFWLNLERA LYRIQEKRES PEVLLTLDIL KHGKRFHATV
SFDTDTGLKQ ALETVNDYNP LMKDFPLNDL LSATELDKIR QALVAIFTHL RKIRNTKYPI
QRALRLVEAI SRDLSSQLLK VLGTRKLMHV AYEEFEKVMV ACFEVFQTWD DEYEKLQVLL
RDIVKRKREE NLKMVWRINP AHRKLQARLD QMRKFRRQHE QLRAVIVRVL RPQVTAVAQQ
NQGEVPEPQD MKVAEVLFDA ADANAIEEVN LAYENVKEVD GLDVSKEGTE AWEAAMKRYD
ERIDRVETRI TARLRDQLGT AKNANEMFRI FSRFNALFVR PHIRGAIREY QTQLIQRVKD
DIESLHDKFK VQYPQSQACK MSHVRDLPPV SGSIIWAKQI DRQLTAYMKR VEDVLGKGWE
NHVEGQKLKQ DGDSFRMKLN TQEIFDDWAR KVQQRNLGVS GRIFTIESTR VRGRTGNVLK
LKVNFLPEII TLSKEVRNLK WLGFRVPLAI VNKAHQANQL YPFAISLIES VRTYERTCEK
VEERNTISLL VAGLKKEVQA LIAEGIALVW ESYKLDPYVQ RLAETVFNFQ EKVDDLLIIE
EKIDLEVRSL ETCMYDHKTF SEILNRVQKA VDDLNLHSYS NLPIWVNKLD MEIERILGVR
LQAGLRAWTQ VLLGQAEDKA EVDMDTDAPQ VSHKPGGEPK IKNVVHELRI TNQVIYLNPP
IEECRYKLYQ EMFAWKMIVL SLPRIQSQRY QVGVHYELTE EEKFYRNALT RMPDGPVALE
ESYSAVMGIV NEVEQYVKVW LQYQCLWDMQ AENIYNRLGE DLNKWQALLV QIRKARGTFD
NAETKKEFGP VVIDYGKVQS KVNLKYDSWH KEVLSKFGQM LGSNMTEFHS QISKSRQELE
QHSVDTASTS DAVTFITYVQ SLKRKIKQFE KQVELYRNGQ RLLEKQRFQF PPSWLYIDNI
EGEWGAFNDI MRRKDSAIQQ QVANLQMKIV QEDRAVESRT TDLLSDWEKT KPVTGNLRPE
EALQALTIYE GKFGRLKDDR EKCAKAKEAL ELTDTGLLSG SEERVQVALE ELQDLKGVWS
ELSKVWEQID QMKEQPWVSV QPRKLRQNLD GLLNQLKNFP ARLRQYASYE FVQRLLKGYM
KINMLVIELK SEALKDRHWK QLMKRLHVNW VVSELTLGQI WDVDLQKNEA IVKDVLLVAQ
GEMALEEFLK QIREVWNTYE LDLVNYQNKC RLIRGWDDLF NKVKEHINSV SAMKLSPYYK
VFEEDALSWE DKLNRIMALF DVWIDVQRRW VYLEGIFTGS ADIKHLLPVE TQRFQSISTE
FLALMKKVSK SPLVMDVLNI QGVQRSLERL ADLLGKIQKA LGEYLERERS SFPRFYFVGD
EDLLEIIGNS KNVAKLQKHF KKMFAGVSSI ILNEDNSVVL GISSREGEEV MFKTPVSITE
HPKINEWLTL VEKEMRVTLA KLLAESVTEV EIFGKATSID PNTYITWIDK YQAQLVVLSA
QIAWSENVET ALSSIGGGGD AAPLHSVLSN VEVTLNVLAD SVLMEQPPLR RRKLEHLITE
LVHQRDVTRS LIKSKIDNAK SFEWLSQMRF YFDPKQTDVL QQLSIQMANA KFNYGFEYLG
VQDKLVQTPL TDRCYLTMTQ ALEARLGGSP FGPAGTGKTE SVKALGHQLG RFVLVFNCDE
TFDFQAMGRI FVGLCQVGAW GCFDEFNRLE ERMLSAVSQQ VQCIQEALRE HSNPNYDKTS
SPITCELLNK QVKVSPDMAI FITMNPGYAG RSNLPDNLKK LFRSLAMTKP DRQLIAQVML
YSQGFRTAEV LANKIVPFFK LCDEQLSSQS HYDFGLRALK SVLVSAGNVK RERIQKIKRE
KEERGEAVDE GEIAENLPEQ EILIQSVCET MVPKLVAEDI PLLFSLLSDV FPGVQYHRGE
MTALREELKK VCQEMYLTYG DGEEVGGMWV EKVLQLYQIT QINHGLMMVG PSGSGKSMAW
RVLLKALERL EGVEGVAHII DPKAISKDHL YGTLDPNTRE WTDGLFTHVL RKIIDNVRGE
LQKRQWIVFD GDVDPEWVEN LNSVLDDNKL LTLPNGERLS LPPNVRIMFE VQDLKYATLA
TVSRCGMVWF SEDVLSTDMI FNNFLARLRS IPLDEGEDEA QRRRKGKEDE GEEAASPMLQ
IQRDAATILQ PYFTSSGLVA KALEHAFQLE HIMDLTRLRC LGSLFSMLHQ ACRNVAQYNA
NHPDFPMQVE QLERYIQRYL VYAILWSLSG DSRLKMRAEL GEYIRRITTV PLPTAPNIPI
IDYEVSISGE WSPWQAKVPQ IEVETHKVAA PDVVVPTLDT VRHEALLYTW LAEHKPLVLC
GPPGSGKTMT LFSALRALPD MEVVGLNFSS ATTPELLLKT FDHYCEYRRT PNGVVLAPVQ
LGKWLVLFCD EINLPDMDKY GTQRVISFIR QMVEHGGFYR TSDQTWVKLE RIQFVGACNP
PTDPGRKPLS HRFLRHVPVV YVDYPGPASL TQIYGTFNRA MLRLIPSLRT YAEPLTAAMV
EFYTMSQERF TQDTQPHYIY SPREMTRWVR GIFEALRPLE TLPVEGLIRI WAHEALRLFQ
DRLVEDEERR WTDENIDMVA LKHFPNIDKE KAMSRPILYS NWLSKDYIPV DQEELRDYVK
ARLKVFYEEE LDVPLVLFNE VLDHVLRIDR IFRQPQGHLL LIGVSGAGKT TLSRFVAWMN
GLSVYQIKVH RKYTGEDFDE DLRTVLRRSG CKNEKIAFIM DESNVLDSGF LERMNTLLAN
GEVPGLFEGD EYATLMTQCK EGAQKEGLML DSHEELYKWF TSQVIRNLHV VFTMNPSSEG
LKDRAATSPA LFNRCVLNWF GDWSTEALYQ VGKEFTSKMD LEKPNYIVPD YMPVVYDKLP
QPPSHREAIV NSCVFVHQTL HQANARLAKR GGRTMAITPR HYLDFINHYA NLFHEKRSEL
EEQQMHLNVG LRKIKETVDQ VEELRRDLRI KSQELEVKNA AANDKLKKMV KDQQEAEKKK
VMSQEIQEQL HKQQEVIADK QMSVKEDLDK VEPAVIEAQN AVKSIKKQHL VEVRSMANPP
AAVKLALESI CLLLGESTTD WKQIRSIIMR ENFIPTIVNF SAEEISDAIR EKMKKNYMSN
PSYNYEIVNR ASLACGPMVK WAIAQLNYAD MLKRVEPLRN ELQKLEDDAK DNQQKANEVE
QMIRDLEASI ARYKEEYAVL ISEAQAIKAD LAAVEAKVNR STALLKSLSA ERERWEKTSE
TFKNQMSTIA GDCLLSAAFI AYAGYFDQQM RQNLFTTWSH HLQQANIQFR TDIARTEYLS
NADERLRWQA SSLPADDLCT ENAIMLKRFN RYPLIIDPSG QATEFIMNEY KDRKITRTSF
LDDAFRKNLE SALRFGNPLL VQDVESYDPV LNPVLNREVR RTGGRVLITL GDQDIDLSPS
FVIFLSTRDP TVEFPPDLCS RVTFVNFTVT RSSLQSQCLN EVLKAERPDV DEKRSDLLKL
QGEFQLRLRQ LEKSLLQALN EVKGRILDDD TIITTLENLK REAAEVTRKV EETDIVMQEV
ETVSQQYLPL STACSSIYFT MESLKQIHFL YQYSLQFFLD IYHNVLYENP NLKGVTDHTQ
RLSIITKDLF QVAFNRVARG MLHQDHITFA MLLARIKLKG TVGEPTYDAE FQHFLRGKEI
VLSAGSTPKI QGLTVEQAEA VVRLSCLPAF KDLIAKVQAD EQFGIWLDSS SPEQTVPYLW
SEDTPATPIG QAIHRLLLIQ AFRPDRLLAM AHVFVSTNLG ESFMSIMEQP LDLTHIVGTE
VKPNTPVLMC SVPGYDASGH VEDLAAEQNT QITSIAIGSA EGFNQADKAI NTAVKSGRWV
MLKNVHLAPG WLMQLEKKLH SLQPHACFRL FLTMEINPKV PVNLLRAGRI FVFEPPPGVK
ANMLRTFSSI PVSRICKSPN ERARLYFLLA WFHAIIQERL RYAPLGWSKK YEFGESDLRS
ACDTVDTWLD DTAKGRQNIS PDKIPWSALK TLMAQSIYGG RVDNEFDQRL LNTFLERLFT
TKSFDSEFKL ACKVDGHKDI QMPDGIRREE FVQWVELLPD AQTPSWLGLP NNAERVLLTT
QGVDMISKML KMQMLEDEDD LAYAETEKKT RTDSTSDGRP AWMRTLHTTA SNWLHLIPKT
LSHLKRTVEN IKDPLFRFFE REVKMGAKLL QDVRQDLADV VQVCEGKKKQ TNYLRTLINE
LVKGILPRSW SHYTVPAGMT VIQWVSDFSE RIKQLQNISQ AAASGGAKEL KNIHVCLGGL
FVPEAYITAT RQYVAQANSW SLEELCLEVN VTTSQGATLD ACSFGVTGLK LQGATCSNNK
LSLSNAISTV LPLTQLRWVK QTNAEKKANV VTLPVYLNFT RADLIFTVDF EIATKEDPRS
FYERGVAVLC TE
//
