ID A0A3Q2CAT8_CYPVA Unreviewed; 469 AA.
AC A0A3Q2CAT8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 18-JUN-2025, entry version 28.
DE SubName: Full=Ligand-dependent corepressor-like {ECO:0000313|Ensembl:ENSCVAP00000001847.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000001847.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000001847.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00320}.
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DR AlphaFoldDB; A0A3Q2CAT8; -.
DR Ensembl; ENSCVAT00000012725.1; ENSCVAP00000001847.1; ENSCVAG00000002875.1.
DR GeneTree; ENSGT00940000162611; -.
DR OMA; KAQHHHN; -.
DR Proteomes; UP000265020; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:TreeGrafter.
DR FunFam; 1.10.10.60:FF:000019; Ligand-dependent corepressor isoform 1; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeodomain-like_sf.
DR InterPro; IPR007889; HTH_Psq.
DR PANTHER; PTHR21545:SF14; LIGAND-DEPENDENT COREPRESSOR; 1.
DR PANTHER; PTHR21545; TRANSCRIPTION FACTOR MLR1/2; 1.
DR Pfam; PF05225; HTH_psq; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50960; HTH_PSQ; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00320};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00320}; Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Transcription {ECO:0000256|ARBA:ARBA00023015};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 368..420
FT /note="HTH psq-type"
FT /evidence="ECO:0000259|PROSITE:PS50960"
FT DNA_BIND 396..416
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00320"
FT REGION 64..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 255..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..267
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 469 AA; 51545 MW; 5B35CF22B21A1C03 CRC64;
MQRMIHQFAA EYTSKTTQED LPLPNGTMKD QSLSRAVNGT GNPVLSKLLM ADQDGPLDLT
VRKAQADQEP SQQDGVLDLS TKKNNSSRGP KTLTGFTLTP GDKGHLLKAE RTLSEVEEED
GLLQKSLQDG LRESYVISNS FKPPLARSLR IKEELLSQKH RLLSQPAALS LANLESAGLL
NHGQSHSLLS QKGSASLWES KAHLESLMKL KQAGGALNDL KDLPTFLENH HHNHHGAFSY
KSSLHQHSHN QVSKAQHHLN EGKREQGHSP PVDLKIPQVR GMDLSWDSHA SELYGYGAMG
VGAGGHGDNS LSRKLRAILP KQNRRGGSLG SLLDGAAEYW NSDLDSSTSG PAYSISDVEV
DPSSKQPRKK RGRYRQYNSE ILEEAIAVVM SGKMSVSKAQ NMYGIPHSTL EYKVKERMGT
LKNPPKKKLK LMMKMEAGGQ EFAGEPDNAS TTTPRDDSLL ESWNKFVLV
//
