ID   A0A3Q2GC68_CYPVA        Unreviewed;       554 AA.
AC   A0A3Q2GC68;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   28-JAN-2026, entry version 34.
DE   SubName: Full=Suppressor of cytokine signaling 5b {ECO:0000313|Ensembl:ENSCVAP00000022570.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000022570.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000022570.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSCVAP00000022570.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
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DR   RefSeq; XP_015249203.1; XM_015393717.1.
DR   AlphaFoldDB; A0A3Q2GC68; -.
DR   STRING; 28743.ENSCVAP00000022570; -.
DR   Ensembl; ENSCVAT00000008966.1; ENSCVAP00000022570.1; ENSCVAG00000005339.1.
DR   GeneID; 107096846; -.
DR   KEGG; cvg:107096846; -.
DR   CTD; 559639; -.
DR   GeneTree; ENSGT00940000164285; -.
DR   OMA; CQNLFNH; -.
DR   OrthoDB; 8820570at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000265020; Unassembled WGS sequence.
DR   GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR   GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR022252; SOCS4/SOCS5_dom.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF12610; SOCS; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF158235; SOCS box-like; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   4: Predicted;
KW   Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          398..493
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          488..537
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000259|PROSITE:PS50225"
FT   REGION          88..142
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          353..373
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   554 AA;  61437 MW;  50E8FFABA77D947D CRC64;
     MWSSLKSRCQ TLFHSAGSTE NRVEVETVQC VVDLGEGGAE VEAQGPATSS QSWSLMPAPV
     VATGRRHHNC VSDIPQIVEI SVDKDSEDAR GISGGVPMAR RDSYSRHAPW GGKKKHSCST
     KTQSSLEADR RSGRLRGCGN RRDRRYGISS IQEINDSGSG GRSLNARSLR QRLSDTVGLC
     LPLPARRRSH SKNPVNSKRK IHLTELMLET CPFPPGSDLA HKWHLIKQHT APVSPHSSTA
     LLDAFDPAHP SPEDEEERLR ERRRLSIEEG VDPPPNAQIH TLEASVPGPS LYKLGPKMAP
     GIGEVSGEAR ASGASSSVSV GSSGVCGSLL GATASSQDCD SEEDSTTLCL QARRPKQRHA
     SGDGHQSRQQ PGPWKVHTQI DYIHCLVPDL LQITALPCYW GVMDRYEAEA LLDGRPEGTF
     LLRDSAQEDY LFSVSFRRYN RSLHARIEQW NHNFSFDAHD PCVFHSSTVT GLLEHYKDPS
     ACMFFEPLLT VPLNRTFPFT LQHLARAAIC RWTTYDGIGS LPLPPALQDF LKEYHYKQKV
     RVRWLEREPP LKVK
//