ID A0A3Q2H6X5_HORSE Unreviewed; 2691 AA.
AC A0A3Q2H6X5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 08-OCT-2025, entry version 28.
DE SubName: Full=Neurobeachin like 1 {ECO:0000313|Ensembl:ENSECAP00000029640.3};
GN Name=NBEAL1 {ECO:0000313|Ensembl:ENSECAP00000029640.3,
GN ECO:0000313|VGNC:VGNC:51476};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000029640.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000029640.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000029640.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000029640.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000029640.3};
RG Ensembl;
RL Submitted (MAY-2025) to UniProtKB.
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DR FunCoup; A0A3Q2H6X5; 1205.
DR STRING; 9796.ENSECAP00000029640; -.
DR PaxDb; 9796-ENSECAP00000029640; -.
DR Ensembl; ENSECAT00000056750.3; ENSECAP00000029640.3; ENSECAG00000020049.4.
DR VGNC; VGNC:51476; NBEAL1.
DR GeneTree; ENSGT00940000155041; -.
DR InParanoid; A0A3Q2H6X5; -.
DR Proteomes; UP000002281; Chromosome 18.
DR Bgee; ENSECAG00000020049; Expressed in brainstem and 23 other cell types or tissues.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR FunFam; 1.10.1540.10:FF:000001; neurobeachin isoform X1; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR050865; BEACH_Domain.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046851; NBCH_WD40.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF115; NEUROBEACHIN-LIKE PROTEIN 1; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF16057; DUF4800; 1.
DR Pfam; PF20426; NBCH_WD40; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 1883..1978
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 1989..2281
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 2485..2526
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1287..1307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1382..1419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1290..1307
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1394..1409
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2691 AA; 306296 MW; D0AA8B4D95305893 CRC64;
MASRERLFEL WMLYCTKKDP DYLKLWLDNF VSSYEQFLDV DFEKLPTRVD DVPPGISLLP
DNILQVLRIQ LLQCVQKMAD GLEEQQQALS ILLVKFFIIL CRNLSNVEEI GTCSYINYVI
TMTTLYIQQL KSKKKEKELA DQTSIEEFVI HALAFCESLY DPYRNWRHRI SGRILSTVEK
SRQKYKPASL TVEFVPFFYQ CFQESEHLKE SLKCCLLHLF GAIIAGGQRN ALQAISPATM
EVLMRVLADC DSWEDGNPEE VGRKVELTLK CLTEVVHILL ASSSDQRQVE TSTLLENYFK
LLNSDHSALP NQRRSRQWES RFIALQIKML NTITAMLDCT DRPVLQAIFL NSNCFEHLIR
LLQNCKVFQG QLDCLAVSTI QALTAVMNKS PAAKEVFKER IGYTHMFEVL KSLGQPAVEL
LKELMNMAVE GDHTSVGILG ISNVQPLLLL IQWLPELESH DLQIFISDWL KRICCINRQS
RTTCVNANMG IRIIETLDSH SSLHRTCAEN LIALHGSLGS QSVSSEEIRR LLRLLRVDES
ECVHPYATPV TRAILTMARK QSLESALQYF NLSHSMAGIT VPSIQKWPGS AFSFNAWFCL
DQDQLTPGSA NKGGKRKQLY SFFTGSGMGF EAFITHSGTL VVAVCTKREY ATVMLPDHSF
CDSLWHNITI VHMPGKRPFG QSVVFIYDNG QQKVSAPLRF PAMNEAFVSC CIGSAGQRTT
TPPPSQIPDP PFSSPITPHR TSFGGILSSA SWGGTIEKSK LITKLISAGT QDSEWGCPTS
LEGQLGSVII FCEALQPPQV KALYLAGPNC LSPWKFQESD MADLPGNVLL HYTAKACKNS
ICLDLSANCL HGRLTGNKVV NWDIKDIINC IGGLNVLFPL LEQISHSSEG QIAEGMNEST
VSELITPVEG DWVVLTSTKA SESRLERNLI ATFILIVKHF IQRHPINQDN LIHSHGVATL
GALLQKVPST LMDVNVLMAI QLLIEQVSLE KNMQLLQQMY QYLLFDFRIW NRGDFPFRIG
HIQYLSTIIK DSRRVFRKKY GVQFLLDTLR IYYGSDCKYS ELSLDDIRTI RTSLYGLIKY
FLCKGGTHEE IQSIMGYIAA ISEEEQLFGI LDILFSLLRT SPTRGQLFLL LFEPGNADIL
YALLLNQKYS DRLREVIFKV MEQMLKCTNV YERSKQRIRL REVGYSGLGL LLSEAPVNTS
LLKNLTNQIV NADPAINFKD LLSVVYMSRR AHINVRVVIC RKILQILQSQ PDAAHQISQQ
VGWQDTLVRL FLKANFENGN TLHKHSRAVS MKDNDKNISA DDNKRNFDEK MDEEKINSFA
STNVSSDQWS LEDRRSLDSN TPLFQEDSSV GELSFKSENQ EEFWHHSPSH LSLDLSRIDS
CELSDSGGQM PDSLPSTPSP IESTKSFSVP SDKESSITSD TGFSDDFSLL ESQERCEEEL
LQLLTNILSY VMCKGLEKSD DDAWIERGQV FAALTKPGIS SELLRPSDEI KLILLQKMLE
WTVTENREAK TNPVTAENAF RLMLIVQDFL QSEGLVNPNV WTEKLLENMM QLFDGLSVWY
SESPVWVKLS QIQIQLLLGF IGRGNLQVCA MASAKLNTLL QTKVIENQDE ACYILGKLEH
VLSQSVKEQT ETYSFLIPLV RTLVSKIYEL LFMNLHLPSL PFTNGSSSFF EDFQEYCSSN
EWQVYIEKYI VPYMKQYETH TFYDGHENMA LYWKDCYEAL MVNMHKRDRE GGESKLKFQE
FFVEPFNRKA RQENLRYNNM LKQLSSQQLA ALRRWKAVQL YLTCERGPWA ERKQNPIHWK
LANVENYSRM RLKLVPNYNF KTHEEASALR DNLGVQHSQP SSDSLLLEVV KQVKVSDMEE
DKLDLPEEEI TARVNIDEKE EQDQKEKLVL SEDCELITMI DVVPGRLEIT TQHIYFYDGS
IEKEDGFDFK WPHSQVREIH LRRYNLRRSA LEIFHVDQSN YFLNFKKEVR NKVYSRLLSL
HSPNSYGTRS PQELFKASGL TQKWVNREIS NFDYLIQINT MAGRTYNDLA QYPVFPWILQ
DYTSEELDLN NPSVFRDLSK PIGVINDKNA KAMREKYENF EDPMGTIDKF HYGTHYSNSA
GVMHYLIRTE PFTTLHIQLQ SGRFDCADRQ FHSIPATWQA LMDNPYDVKE LIPEFFYFPE
FLENQNEFNL GHLQVSKELV NDVILPKWAK SAEDFIYKHR KALESEYVSA HLHEWIDLIF
GYKQRGPAAV EALNVFYYCS YEGAVDLDAL TDEKERKALE GMINNFGQTP CQLLKEPHPP
RLSAEEAVQK QTKMDTPSLN LFQHLPELKS FFIEGISDGI PLIKAIVPKN QSRSFMSQGS
PELLITVSMN YVIGTHGWLP YDRSISNYFT FIRDPTVTNP KTQRSMNGPF APGLEITSKL
FIVSHDAKLL FSAGHWDNSI QVMSLTKGKV ISHNIRHMDI VTCLATDYCG IHLISGSRDT
TCMIWQITQQ GGVPVGLASK PFQILYGHTD EVLSVGISTE LDMAVSGSRD GTVIIHTIQK
GQYMRTLRPP CESSLLLTVP SLAISWEGHV VIYSSIEEKT TLKDKNALHV FSVNGKYLRS
QVLKEQVSDM CVIGEHVITG SLQGFLSIRD LHSLNLSINP LAMRLPIHCV CVTKEHSHIL
VGLEDGKLIV VGVGKPAEMR SGQLTRKLWG SSKRLSQISA GETEYNTQDP K
//
