ID A0A3Q2HUT5_HORSE Unreviewed; 963 AA.
AC A0A3Q2HUT5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 28-JAN-2026, entry version 31.
DE RecName: Full=Cysteine-rich motor neuron 1 protein {ECO:0000256|ARBA:ARBA00073923};
GN Name=CRIM1 {ECO:0000313|Ensembl:ENSECAP00000039076.1,
GN ECO:0000313|VGNC:VGNC:16863};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000039076.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000039076.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000039076.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000039076.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000039076.1};
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSECAP00000039076.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000039076.1};
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- FUNCTION: May play a role in CNS development by interacting with growth
CC factors implicated in motor neuron differentiation and survival. May
CC play a role in capillary formation and maintenance during angiogenesis.
CC Modulates BMP activity by affecting its processing and delivery to the
CC cell surface. {ECO:0000256|ARBA:ARBA00054333}.
CC -!- SUBUNIT: Interacts with BMP4 and BMP7. {ECO:0000256|ARBA:ARBA00061837}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A3Q2HUT5; -.
DR Ensembl; ENSECAT00000056788.2; ENSECAP00000039076.1; ENSECAG00000015608.4.
DR VGNC; VGNC:16863; CRIM1.
DR GeneTree; ENSGT00940000160910; -.
DR Proteomes; UP000002281; Chromosome 15.
DR Bgee; ENSECAG00000015608; Expressed in articular cartilage of joint and 23 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR FunFam; 2.10.22.10:FF:000002; Cysteine rich transmembrane BMP regulator 1; 1.
DR FunFam; 4.10.40.20:FF:000003; cysteine-rich motor neuron 1 protein isoform X1; 1.
DR FunFam; 2.10.22.10:FF:000004; cysteine-rich motor neuron 1 protein isoform X2; 1.
DR FunFam; 2.10.22.10:FF:000001; Cysteine-rich motor neuron 1 protein-like protein; 1.
DR Gene3D; 4.10.40.20; -; 1.
DR Gene3D; 6.20.200.20; -; 5.
DR Gene3D; 2.10.22.10; Antistasin, domain 1; 4.
DR InterPro; IPR004094; Antistasin-like.
DR InterPro; IPR052624; CRIM1.
DR InterPro; IPR045813; CRIM1_C.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011061; Hirudin/antistatin.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR46439; CYSTEINE-RICH MOTOR NEURON 1 PROTEIN; 1.
DR PANTHER; PTHR46439:SF1; CYSTEINE-RICH MOTOR NEURON 1 PROTEIN; 1.
DR Pfam; PF02822; Antistasin; 4.
DR Pfam; PF19442; CRIM1_C; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF00093; VWC; 3.
DR Pfam; PF23334; VWC2L_2nd; 2.
DR SMART; SM00121; IB; 1.
DR SMART; SM00214; VWC; 5.
DR SMART; SM00215; VWC_out; 4.
DR SUPFAM; SSF57603; FnI-like domain; 4.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57262; Leech antihemostatic proteins; 3.
DR PROSITE; PS51252; ANTISTASIN; 4.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS01208; VWFC_1; 3.
DR PROSITE; PS50184; VWFC_2; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..963
FT /note="Cysteine-rich motor neuron 1 protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018776391"
FT TRANSMEM 867..887
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..112
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 334..391
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 401..457
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 469..498
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 507..532
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 539..564
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 567..592
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 606..663
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 677..735
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 743..800
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
SQ SEQUENCE 963 AA; 105918 MW; E1D7B4D48E942FDB CRC64;
MYLVAGGRGL AGCGHLLVSL LGLLLLLARS GTQALVCLPC DESKCEEPRS CPGSIVQGVC
GCCYMCARQR NESCGGAYGL HGACDRGLRC VIRPPLNGDS ITEYEVGVCE DENWDDDQLL
GFEPCNENLV SGCNIINGKC ECDTIRTCNN PFEFPRKDMC LSALKRIEEE KPDCSKARCE
VQFSPRCPED SVLIEGYAPP GECCPLPSRC VCDPAGCLRK VCQPGYLNIL VSKASGKPGE
CCDLYECKPV FSVDCSTVEC PSVQQAVCPL DSYETQVRLT ADGCCTLPTR CECLSGLCGF
PVCEVGSTPR IVSRGDGTPG KCCDVFECVN ETKPACVFNN VEYNDGDMFR MDNCRFCRCQ
GGVSICFTAQ CGELNCERYY VPEGECCPVC EDPVYPFNNP AGCYANGQIR AHGDRWREDD
CTFCQCINGE PHCVATACGQ SCMNPVKVPG ECCPVCEEPT YITIDPPACG ELSNCTLTEK
DCIYGFKLDH NGCRTCQCKN REELCTGLKR GCTLDCPFGF LTDAHNCEIC QCRPRPKKCR
PIICDKYCPF GYLKNKHGCD ICRCKKCPEL PCSKICPLGF QQDSHGCLIC KCREVPASAG
PPVLSGTCLS MDGHHHKNEE SWHDGCRECY CHNGREMCAL ITCPVPACGN PTIHPGQCCP
SCSDDFVVQK PELSTPSICH APGGEYFVEG ETWNIDSCTQ CTCHSGRVLC ETEVCPPLLC
QNPSRTQDSC CPQCTEDTIA KKVVCHFSGK AYADEERWDI DSCTHCYCLQ GQTLCSTVSC
PPLPCVEPIN VEGSCCPMCP EMYVPEPTNI PIEKTNHRGE IDLEVPVWPT PSENDIIHLP
RDMGHLQVDY RDNNRLHPGE DSSLDSIASV VVPIIIGLSI IIAFLFINQK KQWIPLLCWY
RTPTKPSSLN NQLVSVDCKK GTRVQVDGSQ RMLRIAEPDA RFSGFYSMQK QNHLQADNFY
QTV
//
