ID   A0A3Q2WHC7_HAPBU        Unreviewed;       515 AA.
AC   A0A3Q2WHC7;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   28-JAN-2026, entry version 33.
DE   SubName: Full=Forkhead box N4 {ECO:0000313|Ensembl:ENSHBUP00000025553.1};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000025553.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000025553.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSHBUP00000025553.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR   RefSeq; XP_005940234.1; XM_005940172.3.
DR   AlphaFoldDB; A0A3Q2WHC7; -.
DR   STRING; 8153.ENSHBUP00000025553; -.
DR   Ensembl; ENSHBUT00000005677.1; ENSHBUP00000025553.1; ENSHBUG00000007602.1.
DR   GeneID; 102305027; -.
DR   CTD; 121643; -.
DR   GeneTree; ENSGT00940000158984; -.
DR   OMA; QCPTSVY; -.
DR   OrthoDB; 10070006at2759; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:TreeGrafter.
DR   GO; GO:0036302; P:atrioventricular canal development; IEA:Ensembl.
DR   GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR   GO; GO:0003170; P:heart valve development; IEA:Ensembl.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR   GO; GO:0008016; P:regulation of heart contraction; IEA:Ensembl.
DR   FunFam; 1.10.10.10:FF:000122; Forkhead box protein N1; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR049624; FOXN1_4.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR46721; FORKHEAD BOX PROTEIN N1; 1.
DR   PANTHER; PTHR46721:SF2; FORKHEAD BOX PROTEIN N4; 1.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   4: Predicted;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00089};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00089}; Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          194..290
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000259|PROSITE:PS50039"
FT   DNA_BIND        194..290
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          366..405
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   515 AA;  56724 MW;  60282174EC444E57 CRC64;
     MIEGGITSRM SGITENAGHH PSPQDYRLLT TDPSQLREED LPGDLQSLSW LTSVDVPRLQ
     QMADSRGHSN GPSQGSLLEQ QTAQMNNMTM TTSQGSMLHL QSNMQHSPLG ISIINTHSGN
     MSPFSMNGLP SPGYQCPTSV YQPTSQQVYS LSQTGQQCTT GGLYSNVSFN NQSLFTQPRL
     APQEQELQPK SFPKPIYSYS CLIAMALKNS KTGSLPVSEI YSFMKEHFPY FKTAPDGWKN
     SVRHNLSLNK CFEKVENKTS SSSRKGCLWA LNPAKIDKME EEMQKWKRKD LPAIRRSMAN
     PDELDKLITD RPENCRRKPL EPGMTRLNSC PNALPLPVPA QMQPQPIVTL SLPCLPMHQH
     HQLQAQLQAQ ARLAPMSPAP AQTPPLHTVP DLSHSPLTQQ PSKPPDDFYN MQGDAHTEVD
     ALDPSIMDFA LQGNLWEEMK DDSFNLDALG TFSNSPLRLS DCDLGTANLP PVSSGANLSL
     SDVQVTGLYT SYASQDALSS QYMGAPSNSK PIALL
//