ID   A0A3Q3B057_KRYMA        Unreviewed;       534 AA.
AC   A0A3Q3B057;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   28-JAN-2026, entry version 31.
DE   SubName: Full=Suppressor of cytokine signaling 5b {ECO:0000313|Ensembl:ENSKMAP00000017264.1};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000017264.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000017264.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSKMAP00000017264.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
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DR   AlphaFoldDB; A0A3Q3B057; -.
DR   STRING; 37003.ENSKMAP00000017264; -.
DR   Ensembl; ENSKMAT00000017502.1; ENSKMAP00000017264.1; ENSKMAG00000012868.1.
DR   GeneTree; ENSGT00940000164285; -.
DR   OMA; CQNLFNH; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR   GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR022252; SOCS4/SOCS5_dom.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF12610; SOCS; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   PRINTS; PR00678; PI3KINASEP85.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF158235; SOCS box-like; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   4: Predicted;
KW   Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          378..473
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          468..517
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000259|PROSITE:PS50225"
FT   REGION          90..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          239..265
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          306..325
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          333..353
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   534 AA;  59704 MW;  36D936F55E1BDAEB CRC64;
     MNKLRKPENI STPRCQTLFH ASGSSEPRVE ADAVHCVLDL GEGGSSGEVL GPRASSPPWS
     LSPAVTAGRR HHNCVTDIPQ IVEISIDKDS EDVRGGSGGI PLARRDSYSR HAPWGGKKKH
     SCSTKTQSSL ESERHSGRLR GCGNHRDRRY GISSIQEIND PGSAGRGLNP RSLRQRLSDT
     VGLCLPLPVR RHSHSKNPTN SKRKIHLTEL MLETCPFPPG SDLAHKWHLI KQHTAPVSPH
     SSTALLDAFD TGHPSPEDEE ERLRERRRLS IEEGVDPPPN AQIHTLEASV PGSSLYKLGP
     KMASGIGEAS GEARASGDCD SEEDSTTLCL QARRPKQRHA SGEGHQSRQQ PGPWKVHTQI
     DYIHCLVPDL LQITALPCYW GVMDRYEAEA LLDGRPEGTF LLRDSAQEDY LFSVSFRRYN
     RSLHARIEQW NHNFSFDAHD PCVFHSSTVT GLLEHYKDPS ACMFFEPLLT VPLHRTFPFA
     LQHLARAAIC RWTTYDGIGS LPLPPALQDF LKEYHYKQKV RVRWLERETP LRVK
//