ID A0A3Q3B8E3_KRYMA Unreviewed; 345 AA.
AC A0A3Q3B8E3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 18-JUN-2025, entry version 30.
DE RecName: Full=CCN family member 3 {ECO:0000256|ARBA:ARBA00039944};
DE AltName: Full=Cellular communication network factor 3 {ECO:0000256|ARBA:ARBA00042352};
DE AltName: Full=Protein NOV homolog {ECO:0000256|ARBA:ARBA00077787};
GN Name=CCN3 {ECO:0000313|Ensembl:ENSKMAP00000025630.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000025630.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000025630.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, gap junction
CC {ECO:0000256|ARBA:ARBA00004610}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the CCN family. {ECO:0000256|ARBA:ARBA00008125}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
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DR AlphaFoldDB; A0A3Q3B8E3; -.
DR Ensembl; ENSKMAT00000025952.1; ENSKMAP00000025630.1; ENSKMAG00000018904.1.
DR GeneTree; ENSGT00940000159963; -.
DR OMA; PRCNHDL; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031012; C:extracellular matrix; IEA:TreeGrafter.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0005921; C:gap junction; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0008201; F:heparin binding; IEA:TreeGrafter.
DR GO; GO:0005178; F:integrin binding; IEA:TreeGrafter.
DR GO; GO:0007155; P:cell adhesion; IEA:TreeGrafter.
DR GO; GO:0002062; P:chondrocyte differentiation; IEA:TreeGrafter.
DR GO; GO:0045597; P:positive regulation of cell differentiation; IEA:TreeGrafter.
DR FunFam; 2.20.100.10:FF:000046; Cellular communication network factor 4; 1.
DR InterPro; IPR050941; CCN.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR012395; IGFBP_CNN.
DR InterPro; IPR043973; TSP1_CCN.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR11348:SF8; CCN FAMILY MEMBER 3; 1.
DR PANTHER; PTHR11348; CONNECTIVE TISSUE GROWTH FACTOR-RELATED; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF19035; TSP1_CCN; 1.
DR Pfam; PF00093; VWC; 1.
DR PIRSF; PIRSF036495; IGFBP_rP_CNN; 1.
DR SMART; SM00041; CT; 1.
DR SMART; SM00121; IB; 1.
DR SMART; SM00209; TSP1; 1.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS01185; CTCK_1; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS50092; TSP1; 1.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Gap junction {ECO:0000256|ARBA:ARBA00022868};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..345
FT /note="CCN family member 3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018667812"
FT DOMAIN 23..95
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 98..164
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 250..324
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
SQ SEQUENCE 345 AA; 38052 MW; 9678B9290076B995 CRC64;
NFKISKLSLK QLVLLLRIIF LSVLSMCPRR CQCPQDIPVC PPGVPVVLDD CACCLVCASQ
TGQVCSEMNP CDVRKGLQCD YSVNVHRRTG VCVFSVGNVC VLDGSVYQNG QIFFPSCKYQ
CICRDGQIGC VPRCNLDVML PGPDCPMPHK VQVPGECCEK WVCEPQTESS ALGGFALAAF
RQEETVSFNG WDPSLNCVEQ TTEWGACSQT CGMGVSTRVT NKNDRCEMVK QSRLCVVRPC
DIQQEQDSKC QRVARSDTAV HFSYKNCTSV QAYKPRYCGS CMDGRCCTPH RTKTSLVEFQ
CTNGKTTRKP VMAILTCACH SHCPRDNAVW DPSELAYSGL RVPGV
//
