ID A0A3Q3BS73_HAPBU Unreviewed; 1070 AA.
AC A0A3Q3BS73;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 28-JAN-2026, entry version 34.
DE SubName: Full=Multiple EGF-like-domains 10 {ECO:0000313|Ensembl:ENSHBUP00000005076.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000005076.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000005076.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSHBUP00000005076.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}.
CC -!- SIMILARITY: Belongs to the MEGF family.
CC {ECO:0000256|ARBA:ARBA00038377}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3Q3BS73; -.
DR Ensembl; ENSHBUT00000007616.1; ENSHBUP00000005076.1; ENSHBUG00000006507.1.
DR GeneTree; ENSGT00940000157703; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IEA:TreeGrafter.
DR CDD; cd00055; EGF_Lam; 1.
DR FunFam; 2.170.300.10:FF:000007; multiple epidermal growth factor-like domains protein 10; 1.
DR FunFam; 2.170.300.10:FF:000014; Multiple epidermal growth factor-like domains protein 10; 1.
DR FunFam; 2.10.25.10:FF:000114; Multiple epidermal growth factor-like domains protein 11; 1.
DR FunFam; 2.170.300.10:FF:000006; Multiple epidermal growth factor-like domains protein 11; 1.
DR FunFam; 2.170.300.10:FF:000041; Tyrosine protein kinase receptor tie-1, putative; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 5.
DR InterPro; IPR000742; EGF.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR057138; EGF_PEAR1L-like.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR042635; MEGF10/SREC1/2-like.
DR PANTHER; PTHR24043:SF11; MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 10; 1.
DR PANTHER; PTHR24043; SCAVENGER RECEPTOR CLASS F; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF00053; EGF_laminin; 5.
DR Pfam; PF23301; EGF_PEAR1L; 1.
DR Pfam; PF12661; hEGF; 5.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 16.
DR SMART; SM00180; EGF_Lam; 13.
DR PROSITE; PS00022; EGF_1; 14.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 11.
DR PROSITE; PS51041; EMI; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1070
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018584605"
FT TRANSMEM 820..843
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..108
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 150..180
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 188..223
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 231..266
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 279..309
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 317..352
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 406..441
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 497..527
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 578..613
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 621..656
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 679..709
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 717..752
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 170..179
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 213..222
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 256..265
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 299..308
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 342..351
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 431..440
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 517..526
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 603..612
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 646..655
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 699..708
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 742..751
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1070 AA; 115390 MW; B97485A4CFDA52E5 CRC64;
MTTSLLLHRT VLLTVVFCNL PCIASSLNLE DPNVCSHWES YSVTVQESYA HSFNQIYYTS
CTDILNWFKC TKHRMIYRTA YRSGNKTMYR RKSQCCPGFY EKEEICAPHC TESCIHGRCM
APNTCQCEPG WGGSNCSSAC DNDHWGSHCS NRCQCQNGAL CNPITGACIC TPGYRGWRCE
VSCAVGTYGN GCQQKCQCQN GAACHHATGE CKCPPGYTGA LCEELCPPGK HGQQCEERCP
CQNGGVCHHV TGECSCPAGW MGTVCGQPCP EGRFGKNCSQ ECQCHNNGVC VSSTGQCICS
PGYTGERCQD ECPLGTYGAA CAKTCNCENN SKCYHSNGMC LCEPGYTGKT CDVRLCPEGI
YGLRCERKCP CYVQSTRGCH PISGECTCLP GWSGLYCNET CTPGFYGESC QQVCQCQNGA
DCHSVTGECI CAPGFTGPIC SVPCPAGTFG VNCSSSCNCK NKAKCSPIDG SCSCKPGWHG
LDCSINCPSG TWGLGCGSAC ICGNGGACNP LDGHCTCAPG WRGERCELHC QDGTYGLDCK
ERCDCNHADG CHHATGHCRC LAGWTGIHCD SVCAEGHWGP NCSLPCNCKN GASCSPDEGT
CECAPGYRGP TCQRMCPSGR FGKKCAQSCS CTNNGTCHPI DGSCQCYPGW IGSDCSQCGF
TLEIIIYSCP TGHWGPNCIH TCNCHNGAYC SAYDGECKCS PGWTGLYCTQ RCPLGFFGKD
CSQTCQCRNG ADCDHISGQC TCRTGFMGKY CDQKCPPGLY GYGCHQVCDC LNNSTCDHMT
GSCYCNSGWK GARCDQAGVI VVGSLNTLTS AAMHVDSYQI GAIAGIIILV LLVLFLLLLF
IIFRKKQKGK EPTMPSVTYT PAVSVAADYN ITATCEPHLS NYFSNPSYHT LTQCISPQRG
PNGKAKNNQV FVNVKNMDQR KCALLVDHTG TLHAEWKHGD CLNQLDLMKG TPYHASSCSL
SSSENPYATI KDPPMLITKN TECGYVEMKS PARRDSPYAE ISSRSPTNNQ NVYEIDSTIS
TIQSTRDGSG LVKFGQDPYD LPRNSHIPCH YDILPSRESP SSELKKLDSE
//
