ID A0A3Q3FX38_KRYMA Unreviewed; 222 AA.
AC A0A3Q3FX38;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 18-JUN-2025, entry version 31.
DE RecName: Full=Insulin-induced gene protein {ECO:0000256|RuleBase:RU241113};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000016852.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000016852.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- FUNCTION: Mediates feedback control of cholesterol synthesis.
CC {ECO:0000256|RuleBase:RU241113}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}.
CC -!- SIMILARITY: Belongs to the INSIG family.
CC {ECO:0000256|ARBA:ARBA00007475, ECO:0000256|RuleBase:RU241113}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU241113}.
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DR AlphaFoldDB; A0A3Q3FX38; -.
DR Ensembl; ENSKMAT00000017086.1; ENSKMAP00000016852.1; ENSKMAG00000012561.1.
DR GeneTree; ENSGT00580000081600; -.
DR OMA; ENHTWSC; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0032937; C:SREBP-SCAP-Insig complex; IEA:TreeGrafter.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0032869; P:cellular response to insulin stimulus; IEA:TreeGrafter.
DR GO; GO:0006695; P:cholesterol biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0032933; P:SREBP signaling pathway; IEA:TreeGrafter.
DR GO; GO:0036316; P:SREBP-SCAP complex retention in endoplasmic reticulum; IEA:TreeGrafter.
DR InterPro; IPR025929; INSIG_fam.
DR PANTHER; PTHR15301; INSULIN-INDUCED GENE 1; 1.
DR PANTHER; PTHR15301:SF11; INSULIN-INDUCED GENE 1 PROTEIN; 1.
DR Pfam; PF07281; INSIG; 1.
PE 3: Inferred from homology;
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548,
KW ECO:0000256|RuleBase:RU241113};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW ECO:0000256|RuleBase:RU241113};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU241113};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221,
KW ECO:0000256|RuleBase:RU241113};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU241113};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU241113}.
FT TRANSMEM 34..52
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU241113"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU241113"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU241113"
FT TRANSMEM 130..149
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU241113"
FT TRANSMEM 156..175
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU241113"
FT TRANSMEM 187..208
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU241113"
SQ SEQUENCE 222 AA; 24418 MW; 773A71CFB3E53AAC CRC64;
MYMKDKNCSP GPILVCAYGS LHCGRVANLV RRGLVLFTVG VFLALVLNLL QIQRNVTLFP
EEVMTTLFSS AWWIPPCCGT GAAVVGLLYP CLDSHLGEPH KFKREWASVM RCIAVFVGIN
HASAKLDFDN NVQLSLTLAA LSLGLWWTFD RSRSGFGLGI TTAFLATVIT QLLVYNGVYQ
YTSPDFLYVR SWLPCIFFSG GVTVGNIGRQ LAMGGSEKPH MD
//
