ID A0A3Q3LWW7_9LABR Unreviewed; 561 AA.
AC A0A3Q3LWW7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 28-JAN-2026, entry version 30.
DE SubName: Full=Suppressor of cytokine signaling 5b {ECO:0000313|Ensembl:ENSLBEP00000012915.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000012915.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000012915.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSLBEP00000012915.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_020496962.3; XM_020641306.3.
DR AlphaFoldDB; A0A3Q3LWW7; -.
DR STRING; 56723.ENSLBEP00000012915; -.
DR Ensembl; ENSLBET00000013597.1; ENSLBEP00000012915.1; ENSLBEG00000009942.1.
DR GeneID; 109989527; -.
DR CTD; 559639; -.
DR GeneTree; ENSGT00940000164285; -.
DR InParanoid; A0A3Q3LWW7; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 405..500
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 495..544
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 43..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 93..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 242..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 360..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 561 AA; 61883 MW; 50FAF36B9D05D6DF CRC64;
MKKVGNMWSN LKSKCQTLFH SSSSGPGESR PDANAVHCVL DIGQGGSSDE AQVSEAPSPS
RSLLPVPMVT AGRRHHNCVS DIPQIVEITL DKDTEDVRGG SGGVPMARRD SYSRHAPWGG
KKKHSCSTKT QSSLEADRRS GRLRGSGNRR DRRYGIGSIQ EMSDSVSGGR SLNARSLKQR
LSDTVGLCLP LPPRRRSAKN PVTSKRKIHL TELMLETCPF PPGSDLAHKW HLIKQHTAPV
SPHSSTALLD AFDPAHPSPE DEEERLRERR RLSIEEGVDP PPNAQIHTLE ASVPGSSLYK
LGPKLAPGTG ESSGEVRSLG SGSSASAGSS GACSSLLGAA ASAQDCDSEE DSTTLCLQAR
RPKQRHASGD GQLSRQQPGP WKVHTQIDYI HCLVPDLWQI TALPCYWGVM DRYEAEALLD
GRPEGTFLLR DSAQEVYLFS VSFRRYNRSL HARIEQWNHN FSFDAHDPCV FHSSTVTGLL
EHYKDPSACM FFEPLLTAPL NRTFPFGLQH LARAAICRWT TYDGIGSLPL PPALQDFLKE
YHYKQKVRVR WLEREPPTKV K
//
