ID   A0A3Q3NL25_9TELE        Unreviewed;       160 AA.
AC   A0A3Q3NL25;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   18-JUN-2025, entry version 26.
DE   RecName: Full=Adrenomedullin {ECO:0008006|Google:ProtNLM};
OS   Mastacembelus armatus (zig-zag eel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus.
OX   NCBI_TaxID=205130 {ECO:0000313|Ensembl:ENSMAMP00000034140.1, ECO:0000313|Proteomes:UP000261640};
RN   [1] {ECO:0000313|Ensembl:ENSMAMP00000034140.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2025) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the adrenomedullin family.
CC       {ECO:0000256|ARBA:ARBA00010575}.
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DR   AlphaFoldDB; A0A3Q3NL25; -.
DR   Ensembl; ENSMAMT00000035009.2; ENSMAMP00000034140.1; ENSMAMG00000022948.2.
DR   GeneTree; ENSGT00730000112205; -.
DR   InParanoid; A0A3Q3NL25; -.
DR   Proteomes; UP000261640; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR   GO; GO:0031700; F:adrenomedullin receptor binding; IEA:TreeGrafter.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:TreeGrafter.
DR   GO; GO:1990410; P:adrenomedullin receptor signaling pathway; IEA:TreeGrafter.
DR   GO; GO:0010460; P:positive regulation of heart rate; IEA:TreeGrafter.
DR   GO; GO:0003073; P:regulation of systemic arterial blood pressure; IEA:TreeGrafter.
DR   InterPro; IPR051665; Adrenomedullin-reg_peptide.
DR   InterPro; IPR021116; Calcitonin/adrenomedullin.
DR   PANTHER; PTHR23414; ADRENOMEDULLIN, ADM; 1.
DR   PANTHER; PTHR23414:SF3; PRO-ADRENOMEDULLIN; 1.
DR   Pfam; PF00214; Calc_CGRP_IAPP; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW   ECO:0000256|PIRSR:PIRSR621116-50};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261640};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..160
FT                   /note="Adrenomedullin"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5030081819"
FT   DISULFID        97..102
FT                   /evidence="ECO:0000256|PIRSR:PIRSR621116-50"
SQ   SEQUENCE   160 AA;  17912 MW;  AA9F0631D3A1C77F CRC64;
     MRLALHTVIC CCVFTTVLPV VKGATGELNS SQKKRLKAWL QTCMTRDPSG SVTASEQYLD
     INAEPHQDEN AKTVSPLSSF GLLIRRRRSA SSKSSGCFLV TCVYHDLLDR LYKHNKEKEV
     KAPERKMGSQ GYGRRRRSLL DVTKLALQTG RHSQSTEADQ
//