ID A0A3Q3WCY4_MOLML Unreviewed; 278 AA.
AC A0A3Q3WCY4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 28-JAN-2026, entry version 31.
DE RecName: Full=Insulin-like growth factor binding protein 2b {ECO:0008006|Google:ProtNLM};
OS Mola mola (Ocean sunfish) (Tetraodon mola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Molidae; Mola.
OX NCBI_TaxID=94237 {ECO:0000313|Ensembl:ENSMMOP00000006614.1, ECO:0000313|Proteomes:UP000261620};
RN [1] {ECO:0000313|Ensembl:ENSMMOP00000006614.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSMMOP00000006614.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- FUNCTION: IGF-binding proteins prolong the half-life of the IGFs and
CC have been shown to either inhibit or stimulate the growth promoting
CC effects of the IGFs on cell culture. They alter the interaction of IGFs
CC with their cell surface receptors. {ECO:0000256|ARBA:ARBA00003811}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR AlphaFoldDB; A0A3Q3WCY4; -.
DR Ensembl; ENSMMOT00000006738.1; ENSMMOP00000006614.1; ENSMMOG00000005160.1.
DR OMA; TKMKTNQ; -.
DR Proteomes; UP000261620; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0031994; F:insulin-like growth factor I binding; IEA:TreeGrafter.
DR GO; GO:0031995; F:insulin-like growth factor II binding; IEA:TreeGrafter.
DR GO; GO:0048640; P:negative regulation of developmental growth; IEA:UniProtKB-ARBA.
DR GO; GO:0043567; P:regulation of insulin-like growth factor receptor signaling pathway; IEA:TreeGrafter.
DR CDD; cd00191; TY; 1.
DR FunFam; 4.10.40.20:FF:000001; Insulin-like growth factor binding protein 5; 1.
DR FunFam; 4.10.800.10:FF:000002; Insulin-like growth factor-binding protein 2; 1.
DR Gene3D; 4.10.40.20; -; 1.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR012210; IGFBP-2.
DR InterPro; IPR000867; IGFBP-like.
DR InterPro; IPR022321; IGFBP_1-6_chordata.
DR InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR11551; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN; 1.
DR PANTHER; PTHR11551:SF5; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 2; 1.
DR Pfam; PF00219; IGFBP; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR PRINTS; PR01976; IGFBPFAMILY.
DR PRINTS; PR01978; IGFBPFAMILY2.
DR SMART; SM00121; IB; 1.
DR SMART; SM00211; TY; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR PROSITE; PS00222; IGFBP_N_1; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Growth factor binding {ECO:0000256|ARBA:ARBA00023183};
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000261620};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..278
FT /note="Insulin-like growth factor binding protein 2b"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018626898"
FT DOMAIN 24..105
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51323"
FT DOMAIN 174..256
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
SQ SEQUENCE 278 AA; 31228 MW; B4AAB3BE6C4C7141 CRC64;
MTTYFTYRLL FAYLALLRIV LADLAFRCSS CTAEHLAMCP QVKAFCPEIV REMGCGCCPV
CARQEGELCG VYTPRCSSGL RCYPSAEAEF PLQQLIQGLG RCGPKVDLDI TTSLEDLATY
EVQGTENPLT KRPVIDARFW QSAMIQYMNE RRTKMKANQL EDSRIQKVPQ TVPGSACQQE
LNQVLVEISR MTSEDNRGPL ENLYMLKFPN CDRHGLYNLK QCNMSTRGQR GECWCVHPFT
GVQIPATPRV RGDPNCNQFQ EELKVMPTAA AVTAATSR
//
