ID   A0A3Q4HBG9_NEOBR        Unreviewed;       256 AA.
AC   A0A3Q4HBG9;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   28-JAN-2026, entry version 30.
DE   SubName: Full=Transmembrane BAX inhibitor motif containing 1a {ECO:0000313|Ensembl:ENSNBRP00000020460.1};
OS   Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Lamprologini; Neolamprologus.
OX   NCBI_TaxID=32507 {ECO:0000313|Ensembl:ENSNBRP00000020460.1, ECO:0000313|Proteomes:UP000261580};
RN   [1] {ECO:0000313|Ensembl:ENSNBRP00000020460.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSNBRP00000020460.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the BI1 family. {ECO:0000256|RuleBase:RU004379}.
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DR   AlphaFoldDB; A0A3Q4HBG9; -.
DR   STRING; 32507.ENSNBRP00000020460; -.
DR   Ensembl; ENSNBRT00000021013.1; ENSNBRP00000020460.1; ENSNBRG00000015690.1.
DR   GeneTree; ENSGT01050000244890; -.
DR   OMA; IKIFIRV; -.
DR   Proteomes; UP000261580; Unassembled WGS sequence.
DR   Bgee; ENSNBRG00000015690; Expressed in zone of skin and 9 other cell types or tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:TreeGrafter.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:TreeGrafter.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; IEA:TreeGrafter.
DR   CDD; cd10428; LFG_like; 1.
DR   InterPro; IPR006214; Bax_inhibitor_1-related.
DR   PANTHER; PTHR23291; BAX INHIBITOR-RELATED; 1.
DR   PANTHER; PTHR23291:SF35; PROTEIN LIFEGUARD 3; 1.
DR   Pfam; PF01027; Bax1-I; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU004379};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261580};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU004379};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU004379}.
FT   TRANSMEM        46..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004379"
FT   TRANSMEM        79..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004379"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004379"
FT   TRANSMEM        136..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004379"
FT   TRANSMEM        166..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004379"
FT   TRANSMEM        196..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004379"
FT   TRANSMEM        229..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004379"
SQ   SEQUENCE   256 AA;  28396 MW;  B60B53199016E94A CRC64;
     GIMSHYPPGY DESHGPMYGP QGGNYPPPPP YGFPSYGGSQ PGYPSVYLLL ACQLLVTTAI
     VAIFTFVQPV KSFVRQNSAV YWASYAVYFI THIVLVCCKG PRRKFPWNMI LLGLFTLSLS
     YMTGTISSYY DTKAVFLALG ITAVVCIAVT VFCFQTKVDF TKCQGLFCVL GIVVFVTGII
     TAIVLSFKYI FWLHMLYAAI GAIVFTLFLA YHTQLLIGNR KHSISPEEYV FAALSIYVDI
     IQIFLFLLQI IGASTK
//